Evolutionary stability
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Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affected DDR genes, leading to genome instability and high risk of diseases, in particular, cancer.
17p vishanshan 27-06-2024 2 1 Download
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All species within a community either directly or indirectly interact with each other. Such interactions serve as the nucleus of both ecological and evolutionary processes. This study focused on dominant tree species' interspecific associations and the stability of evergreen broadleaved forest stands in Phu Quoc National Park in Kien Giang province of Vietnam.
10p vikissinger 21-12-2023 3 1 Download
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Ebook Knowledge emergence, social, technical, and evolutionary dimensions of knowledge creation – Part 1 presents the following content: Chapter 1: Introduction: Chapter 1: Introduction: Knowledge emergence; Chapter 2: Emergence of “Ba”: A conceptual framework for the continuous and self-transcending process of knowledge creation; Chapter 3: Bringing care into knowledge development of business organizations; Chapter 4: The influence of new 3-D CAD systems on knowledge creation in product development; Chapter 5: The impact of technology on knowledge creation: A study of experimentation in in...
155p runthenight08 12-04-2023 6 1 Download
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Robustness and evolutionary stability of gene expression in the human genome are established by an array of redundant enhancers. Results: Using Hi-C data in multiple cell lines, we report a comprehensive map of promoters and active enhancers connected by chromatin contacts, spanning 9000 enhancer chains in 4 human cell lines associated with 2600 human genes.
14p vielonmusk 30-01-2022 11 0 Download
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CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the role of CTCF binding in their evolution and stability remains elusive.
19p vielonmusk 30-01-2022 10 0 Download
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Gene flow between species, across ploidal levels, and even between evolutionary lineages is a common phenomenon in the genus Arabidopsis. However, apart from two genetically fully stabilized allotetraploid species that have been investigated in detail, the extent and temporal dynamics of hybridization are not well understood. An introgression zone, with tetraploid A. arenosa introgressing into A. lyrata subsp.
18p vilarryellison 29-10-2021 9 1 Download
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Malaria mosquitoes have had a remarkable stability in the number of chromosomes in their karyotype (2n = 6) during 100 million years of evolution. Moreover, autosomal arms were assumed to maintain their integrity even if their associations with each other changed via whole-arm translocations. Here we use high-coverage comparative physical genome mapping of three Anopheles species to test the extent of evolutionary conservation of chromosomal arms in malaria mosquitoes.
14p vibeauty 23-10-2021 20 2 Download
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The regulatory landscape of a gene locus often consists of several functionally redundant enhancers establishing phenotypic robustness and evolutionary stability of its regulatory program. However, it is unclear what mechanisms are employed by redundant enhancers to cooperatively orchestrate gene expression.
12p viseulgi2711 31-08-2021 12 1 Download
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Plant ALDH10 enzymes are aminoaldehyde dehydrogenases (AMADHs) that oxidize different ω-amino or trimethylammonium aldehydes, but only some of them have betaine aldehyde dehydrogenase (BADH) activity and produce the osmoprotectant glycine betaine (GB).
16p viminato2711 22-05-2020 9 0 Download
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Fusarium species cause considerable crop losses worldwide and necessitate an expensive use of chemical pesticides. Resistant genes can be used to improve plant resistance through gene editing and gene silencing strategies. Currently, information on host defences against Fusarium species is limited. Through in-silico tools, identification of genes and understanding of disease resistance mechanism has become possible.
19p kethamoi4 16-04-2020 24 2 Download
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We purified pancreatic deoxyribonucleases I (DNases I) from three snakes, Elaphe quadrivirgata, Elaphe climaco-phoraandAgkistrodon blomhoffii, and cloned their cDNAs. Each mature snake DNase I protein comprised 262 amino acids. Wild-type snake DNases I with Leu130 were more thermally unstable than wild-type mammalian and avian DNases I with Ile130. After substitution of Leu130Ile, the thermal stabilities of the snake enzymes were higher than those of their wild-type counterparts and similar to mam-malian wild-type enzyme levels....
8p tumor12 20-04-2013 40 2 Download
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One of the most influential studies of the pace of evolutionary change was pub- lished in 1971 by two young paleontologists at the American Museum of Natural History named Niles Eldredge and Stephen Jay Gould. They pointed out that the fossils of a typical species showed few signs of change during its lifetime. New species branching off from old ones had small but distinctive differences. Eldredge carefully documented this stasis in trilobites, an extinct lineage of armored arthropods. He counted the rows of columns in the eyes of each sub- species.
40p machuavo 19-01-2013 40 2 Download