Expeditious route for the synthesis

A series of 1-(1,3,4-thiadiazolo)-2-thioxo-pyrimidines 4a-g are synthesized by the condensation of monosubsituted thioureas la-g, ethyl acetoacetate 2 and aryl aldehyde 3 in dry media using microwave irradiation. The reactions are completed in very short time with high yield. The use of inorganic solid supports has been proved as an alternative mean of synthetic media.

6p angicungduoc1 02-12-2019 13 0   Download

The incidence of fungal infections is considered a serious public health problem worldwide. The limited number of antimycotic drugs available to treat human and animal mycosis, the undesirable side effects and toxicities of the currently available drugs, and the emergence of fungal resistance emphasizes the urgent need for more effective antimycotic medicines. In this paper, we describe a rapid, simple, and efficient synthetic route for preparation of the antifungal agent butenafine on a multigram scale.

11p trinhthamhodang1 14-11-2019 13 0   Download