Experimental evolution

Ebook "Evolutionary transitions to multicellular life: Principles and mechanisms" integrates our understanding of the factors and processes underlying the evolution of multicellularity by providing several complementary perspectives (both theoretical and experimental) and using examples from various lineages in which multicellularity evolved.

489p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Relaxin and related peptides" discusses the established paradigms, the contradictions, and the most recent findings and future directions in the field of relaxin research. The array of diverse topics are highlighted, ranging from evolution of relaxin family peptides and receptors to their cell signaling, from the role of relaxin in reproduction to the newly discovered functions in cancer progression and in the nervous system.

161p tracanhphuonghoa1007 22-04-2024 3 1   Download

Ebook "Adhesion-GPCRs: Structure to function" have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

216p cotieubac1004 15-03-2024 2 0   Download

The neutron-rich nuclei 63,65Cr were produced at the RIBF facility at RIKEN in the first campaign of the “Shell Evolution And Search for Two-plus energies At RIBF” (SEASTAR) project. The preliminary results of in-beam gamma ray spectroscopy of these nuclei, the detail of experimental setup and the particle identification method are presented.

9p vidumbledore 19-01-2023 10 2   Download

The difficulty in predicting locally and globally the transient evolution of two-phase or multiphase flows in complex systems is well recognized in nuclear thermal-hydraulics. Large efforts involving the expenditure of huge resources during the last three decades in previous century brought to the creation of giant databases (e.g. including experimental data and results of computer code calculations) and to the perception that the safety of nuclear reactors is guaranteed notwithstanding residual areas of unawareness.

7p vironald 15-12-2022 11 3   Download

Population genetic theory predicts that rapid adaptation is largely driven by complex traits encoded by many loci of small effect. Because large-effect loci are quickly fixed in natural populations, they should not contribute much to rapid adaptation.

15p vigalileogalilei 27-02-2022 11 1   Download

The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology and excellent experimental tractability for molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids and blood-feeding bed bugs, we present the genome sequence and comparative analyses centered on the milkweed bug Oncopeltus fasciatus, a seed feeder of the family Lygaeidae.

26p vigalileogalilei 27-02-2022 8 1   Download

We present a new method, Fine-Mapping of Adaptive Variation (FineMAV), which combines population differentiation, derived allele frequency, and molecular functionality to prioritize positively selected candidate variants for functional follow-up. We calibrate and test FineMAV using eight experimentally validated “gold standard” positively selected variants and simulations.

18p vialfrednobel 29-01-2022 11 0   Download

Understanding the genetic architecture of temperature adaptation is key for characterizing and predicting the effect of climate change on natural populations. One particularly promising approach is Evolve and Resequence, which combines advantages of experimental evolution such as time series, replicate populations, and controlled environmental conditions, with whole genome sequencing.

25p viarchimedes 26-01-2022 7 0   Download

To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals.

43p viarchimedes 26-01-2022 4 0   Download

A non-material shell finite element model is developed and applied to the example problem of a slack steel belt moving on two rotating drums. For the first time in the open literature we demonstrate an approach for predicting the time evolution of the lateral run-off velocity of the belt in response to its geometric imperfection and angular drum misalignment.

18p guernsey 28-12-2021 21 0   Download

As a principle of project delivery, Agile has always been about achieving better outcomes faster through the use of a dynamic, collaborative framework than traditional methodologies. Behavior Driven development (BDD) offers a modern agile software development approach which is seen as an evolution of Test Driven Development (TDD) and Acceptance Test Driven Development (ATDD).

7p visteveballmer 06-11-2021 9 0   Download

Influenza viruses are undergoing continuous and rapid evolution. The fatal influenza A/H7N9 has drawn attention since the first wave of infections in March 2013, and raised more grave concerns with its increased potential to spread among humans. Experimental studies have revealed several host and virulence markers, indicating differential host binding preferences which can help estimate the potential of causing a pandemic. Here we systematically investigate the sequence pattern and structural characteristics of novel influenza A/H7N9 using computational approaches.

10p vibeauty 23-10-2021 7 1   Download

Studies combining experimental evolution and next-generation sequencing have found that adaptation in sexually reproducing populations is primarily fueled by standing genetic variation. Consequently, the response to selection is rapid and highly repeatable across replicate populations. Some studies suggest that the response to selection is highly repeatable at both the phenotypic and genomic levels, and that evolutionary history has little impact.

17p vitzuyu2711 29-09-2021 10 1   Download

The marine polychaete annelid Platynereis dumerilii has recently emerged as a prominent organism for the study of development, evolution, stem cells, regeneration, marine ecology, chronobiology and neurobiology within metazoans.

11p vitzuyu2711 29-09-2021 11 1   Download

Non-coding gene regulatory enhancers are essential to transcription in mammalian cells. As a result, a large variety of experimental and computational strategies have been developed to identify cis-regulatory enhancer sequences.

22p visilicon2711 20-08-2021 17 0   Download

Recent experimental work has shown that the evolutionary dynamics of bacteria expanding across space can differ dramatically from what we expect under well-mixed conditions. During spatial expansion, deleterious mutations can accumulate due to inefficient selection on the expansion front, potentially interfering with and modifying adaptive evolutionary processes.

11p vijeeni2711 24-07-2021 12 0   Download

Fitness epistasis, the interaction effect of genes at different loci on fitness, makes an important contribution to adaptive evolution. Although fitness interaction evidence has been observed in model organisms, it is more difficult to detect and remains poorly understood in human populations as a result of limited statistical power and experimental constraints.

13p vijeeni2711 24-07-2021 9 0   Download

Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover mutations that confer phenotypic functions of interest. However, the task of finding and understanding all beneficial mutations of an ALE experiment remains an open challenge for the field.

16p vijeeni2711 30-06-2021 22 1   Download

We can describe protein-protein interactions (PPIs) as sets of distinct domain-domain interactions (DDIs) that mediate the physical interactions between proteins. Experimental data confirm that DDIs are more consistent than their corresponding PPIs, lending support to the notion that analyses of DDIs may improve our understanding of PPIs and lead to further insights into cellular function, disease, and evolution.

15p viwyoming2711 16-12-2020 12 0   Download