Expression dynamics

Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.

17p vikoch 27-06-2024 3 1   Download

Part 2 of ebook "Neurodynamics of cognition and consciousness" provides readers with contents including: cognitive computing for sensory perception; shape recognition through dynamic motor representations; a biologically inspired dynamic model for object recognition; a brain-inspired model for recognizing human emotional states from facial expression; nonlinear high-order model for dynamic synapse with multiple vesicle pools;...

179p dongmelo 20-05-2024 5 2   Download

Ebook "Epigenetics in cardiac disease" describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field.

321p ladongphongthanh1008 22-04-2024 7 2   Download

Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across development in the rodent brain, including mutually exclusive copies of the fifth protein-coding exon detected in the neonate (5N) and adult (5A).

14p vibransone 28-03-2024 2 1   Download

The activation of the telomere maintenance mechanism (TMM) is one of the critical drivers of cancer cell immortality. In gliomas, TERT expression and TERT promoter mutation are considered to reliably indicate telom‑ erase activation, while ATRX mutation and/or loss indicates an alternative lengthening of telomeres (ALT). However, these relationships have not been extensively validated in tumor tissues.

16p viellison 28-03-2024 3 1   Download

Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients sufers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamics of gene expression and DNA methylation in blood samples of IBD patients treated with the TNF antagonist infliximab and analyzed the predictive potential regarding therapy outcome.

20p viellison 28-03-2024 5 2   Download

Ebook "The role of degenerate states in chemistry (Advances in chemical physics, Volume 124)" provides a forum for critical, authoritative evaluations in every area of the discipline. In a format that encourages the expression of individual points of view, experts in the field present comprehensive analyses of subjects of interest. Volume 124 collects innovative papers on "Complex States of Simple Molecular Systems," "Electron Nuclear Dynamics," "Conical Intersections and the Spin-Orbit Interaction," and many more related topics.

812p coduathanh1122 27-03-2024 1 1   Download

Ebook "Systems biology and biotechnology of Escherichia coli" covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism.

470p cotieubac1004 15-03-2024 2 0   Download

Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo.

24p vicwell 29-02-2024 2 1   Download

Ebook "Methods of microarray data analysis V" provides readers with contents including: data mining of malaria parasite gene expression for possible translational research; constructing probabilistic genetic networks of plasmodium falciparum from dynamical expression signals of the intraerythrocytic development cycle; simple methods for peak and valley detection in time series microarray data;...

186p tachieuhoa 28-01-2024 5 2   Download

In ebook "Nuclear dynamics: Molecular biology and visualization of the nucleus" the dynamics of nuclear structures described furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

285p tachieuhoa 28-01-2024 6 2   Download

Ebook "Human T-lymphotropic viruses: Methods and protocols" detailed volume draws attention to other members of the Retrovirus family, namely the Human T-lymphotropic Viruses (HTLVs), featuring the most updated technical information about HTLV determination and the methods to investigate their interaction with the host immune system and interfering pathogens.

221p lucchinguyen 28-12-2023 6 2   Download

Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis and progression to acute myeloid leukemia, myelodysplasia-related (AML-MR). A major mechanism of pathogenesis of MDS is the aberration of the epigenetic landscape of the hematopoietic stem cells and/or progenitor cells, especially DNA cytosine methylation, and demethylation.

18p vialfrednobel 23-12-2023 4 3   Download

Part 1 book "Diseases of mites and ticks" includes content: Using RNA interference to determine the role of varisin in the innate immune system of the hard tick dermacentor variabilis (Acari: Ixodidae); silencing expression of the defensin, varisin, in male Dermacentor variabilis by RNA interference results in reduced anaplasma marginale infections;.... and other contents.

158p oursky09 12-11-2023 6 2   Download

Ebook "Skillful listening and speaking 2: Student's book pack" designed for students in university programmes. Its rigorous step-by-step approach develops language proficiency and academic skills, helping students perform at their best. Skillful Second Edition engages and challenges students with interesting and relevant topics, using fresh, dynamic content and meaningful academic tasks.

112p luctumac0210 13-11-2023 20 10   Download

Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC development and progression is not well understood. Methods We sought to establish a dynamic Chinese hamster OSCC animal model, construct miRNA differential expression profiles of its occurrence and development, predict its targets, and perform functional analysis and validation in vitro.

19p vischultz 20-10-2023 6 2   Download

Novel antibody‒drug conjugates (ADC) have shown great efficacy in HER2-low advanced breast cancer. However, the clinical features of HER2-low disease still need to be clarified. The current study aims to evaluate the distribution and dynamic change in HER2 expression in patients with disease recurrence and the clinical outcome of those patients.

9p vischultz 20-10-2023 3 1   Download

Breast cancer (BC) with low human epidermal growth factor receptor 2 (HER2) expression is attracting much attention due to the breakthrough progress of novel anti-HER2 antibody-drug conjugates. HER2 expression is examined in patients with HER2-low BC and their distant metastases in this study, so as to further clarify the dynamic characteristics of HER2 low status in the process of disease progression.

12p vioracle 29-09-2023 4 2   Download

Protein Kinase C-epsilon (PKCε) is a member of the novel subfamily of PKCs (nPKCs) that plays a role in cancer development. Studies have revealed that its elevated expression levels are associated with cervical cancer.

15p vioracle 29-09-2023 5 2   Download

Long non-coding RNAs play an important role in the development of colorectal cancer (CRC), while many CRC-related lncRNAs have not yet been identified. The relationship between the expression of LINC00955 (Long Intergenic Non-protein Coding RNA 955) and the prognosis of colorectal cancer patients was analyzed using the sequencing results of the TCGA database.

20p vioracle 29-09-2023 3 2   Download