Expression system

Glioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features including extensive hypoxia. Hypoxia in glioblatoma associates with complex signaling patterns including activation of several pathways such as MAPK, PI3K-AKT/mTOR and IL-6/JAK/STAT3 with the master regulator HIF-1, which in turn drive particular tumor behaviors determining, in the end, treatment outcomes and patients fate.

12p vishanshan 27-06-2024 2 1   Download

Breast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The incidence and mortality of BC are rapidly increasing, posing great challenges to the health system and economy of every nation.

11p vishanshan 27-06-2024 1 1   Download

The goal of this book is to give you the skills and knowledge necessary to succeed in calculus. Much of the difficulty calculus students face is with algebra. They have to solve equations, find equations of lines, study graphs, solve word problems, and rewrite expressions—all of these require a solid background in algebra. You will get experience with all this and more in this book. Not only will you learn about the basic functions in this book, you also will strengthen your algebra skills because all of the examples and most of the solutions are given with a lot of detail.

479p zizaybay1103 29-05-2024 4 2   Download

Family business planning has traditionally centered on two issues - estate planning and succession. These goals are far too limited for today's family firm. Business families want to turn the business into not only a tool for profit, but for self-expression, innovation and legacy. The authors introduce the new concept of the Parallel Planning Process, explaining how to integrate the needs and expectations of the family and business systems in order to create an organic and entrepreneurial unit.

289p vimeyers 29-05-2024 4 2   Download

Ebook "Mycobacteria protocols (Second edition)" updates and refines the methods of the well-received first edition while adding newly developed methods culled from the most cutting-edge research in the field. Ranging from the basics of sub-cellular fractionation to advanced methods using specialized growth conditions and whole genome, transcriptome and proteome analysis, the chapters conform to the Methods in Molecular Biology™ series format, providing step-by-step laboratory protocols, lists of necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls.

485p dongmelo 27-05-2024 8 3   Download

Ebook "Heterologous gene expression in E. coli: Methods and protocols" herein describe methods, for example, to successfully express proteins in E. coli that would otherwise form aggregates in this host, to add post-translational modifications, to incorporate non-standard amino acid residues or moieties into E. coli expressed proteins, to identify binding partners, and to express membrane proteins.

312p dongmelo 27-05-2024 6 2   Download

Lecture Computer literacy: The Linux file system (Cont.). This lesson provides students with content about: operations common to directories and regular files; operations unique to regular files; viewing contents of text files;... Please refer to the detailed content of the lecture!

22p codabach1016 03-05-2024 1 0   Download

Ebook "Endocrine FGFs and Klothos" to restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

250p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Mechanisms of insulin action" will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.

223p tracanhphuonghoa1007 22-04-2024 2 2   Download

In this paper, we investigate a novel downlink Small Cell (SC) system based on the Cell Free (CF) model, with the deployment of Unmanned Aerial Vehicles (UAVs) as Aerial Relay Stations (ARSs) simultaneously serving users in a specific area. The new SC model concept is expressed in the user-centric idea that the user will choose only one ARS with the best conditions for communication, and the concept of “cell" or “cell boundary" will no longer exist.

8p viohoyo 25-04-2024 5 2   Download

The research carried out a critical analysis of existing labor potential assessment methodologies at the regional level, which allowed taking into account the identified deficiencies offer the author's approach to express diagnostics, which does not require a special wide survey, allows to get objective results and it is the basis for identifying the most important problems and priority ways of solving them. The essence of the approach is to conduct regional clustering procedure on the level of the state of the labor potential on the basis of the author's indicator system.

8p longtimenosee09 08-04-2024 3 1   Download

Part 2 of ebook "Software engineering, artificial intelligence, networking and parallel/distributed computing 2011" includes the following main contents: comparison of region based and weighted principal component analysis and locally salient ICA in terms of facial expression recognition; web health portal to enhance patient safety in Australian healthcare systems; peer-based complex profile management; detecting unwanted email using VAT; improving smart card security using elliptic curve cryptography over prime field (Fp);...

101p khuynhlinhnguyet1009 05-04-2024 2 1   Download

Ebook C - Answer Book (The C programming language) presents the following content: Chapter 1: tutorial introduction, chapter 2: types, operators, & expressions, chapter 3: control flow, chapter 4: functions & program structure, chapter 5: pointers & arrays, chapter 6: structures, chapter 7: input & output, chapter 8: unix system interface.

214p longtimenosee08 31-03-2024 2 1   Download

Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.

14p vibransone 28-03-2024 2 2   Download

The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.

10p vibransone 28-03-2024 6 2   Download

Vaccines dramatically affect an individual’s adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus.

18p vioraclene 31-03-2024 6 2   Download

Tumour necrosis factor (TNF) superfamily cytokines and their receptors regulate diverse immune system functions through a common set of signalling pathways. Genetic variants in and expression of individual TNF superfamily cytokines, receptors and signalling proteins have been associated with autoimmune and inflammatory diseases, but their interconnected biology has been largely unexplored.

15p vioraclene 31-03-2024 2 2   Download

The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations.

15p vioraclene 31-03-2024 4 2   Download

Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive.

21p vioraclene 31-03-2024 2 2   Download

Inter-tissue molecular interactions are critical to the function and behavior of biological systems in multicellular organisms, but systematic studies of interactions between tissues are lacking. Also, existing studies of inter-tissue interactions are based on direct gene expression correlations, which can’t distinguish correlations due to common genetic architectures versus biochemical or molecular signal exchange between tissues.

15p vioraclene 31-03-2024 8 2   Download