Extracellular matrix

Shear wave elastography can evaluate tissue stiffness. Previous studies showed that the elasticity characteristics of breast lesions were related to the components of extracellular matrix which was regulated by transforming growth factor beta 1(TGF-β1) directly or indirectly.

13p vielonmusk 21-01-2022 13 1   Download

Bài viết "Tranexamic acid trong điều trị lão hóa da" trình bày đại cương về lão hóa da, tế bào mast và tái cấu trúc chất nền ngoại bào (extracellular matrix - ECM), dược học của tranexamic, tác dụng TXA trong điều trị lão hóa da.

5p viamman2711 17-08-2020 81 7   Download

Antimicrobial resistance is an emerging challenge for health personnel and researchers. In such scenario, alternative strategies targeting novel ways to kill or inhibit growth of microbes are need of the hour. Antimicrobial peptide can be a promising candidate to deal with this crisis. Extracellular matrix protein vitronectin (Vn) is recently being established as a bactericidal agent against certain microbes. Caprine Vn has got few structural alterations as compare to human Vn.

7p nguaconbaynhay5 16-05-2020 15 1   Download

Bài giảng “Suy tim: Phân suất tống máu bảo tồn từ bệnh sinh đến lâm sàng” trình bày các nội dung: Các giai đoạn đổ đầy thất trái, yếu tố quyết định chức năng tâm trương, extracellular matrix, thay đổi cấu trúc HFpEF và HfrEF,… Mời các bạn cùng tham khảo nội dung chi tiết.

3p tsmttc_004 13-06-2015 103 13   Download

In the course of trying to understand the pathogenesis of leishmaniasis in relation to extracellular matrix (ECM) elements, laminin, a major ECM protein, has been found to bind saturably and with high affinity to a 67-kDa cell surface protein of Leishmania donovani. This interaction involves a single class of binding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding activity was significantly enhanced by Zn2+, an effect possibly mediated through Cys-rich zinc finger-like sequences on laminin....

8p system191 01-06-2013 41 4   Download

The serpin plasminogen activator inhibitor type 1 (PAI-1) plays an important role in physiological processes such as thrombolysis and ®brinolysis, as well as pathophysiological processes such as thrombosis, tumor invasion and metas-tasis. In addition to inhibiting serine proteases, mainly tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, PAI-1 interacts with di€erent components of the extracellular matrix, i.e. ®brin, heparin (Hep) and vitronectin (Vn).

9p research12 29-04-2013 25 3   Download

Thea3b1 integrin is an adhesion receptor for extracellular matrix proteins including isoforms of laminin, and the changes of its expression level in various cancer cells are thought to cause their malignant phenotypes. We have cloned an approximately 4 kb DNA fragment of the 5¢-flanking region of the murinea3 integrin gene and analyzed its promoter activity.

9p research12 23-04-2013 36 3   Download

The matrix metalloproteinase (MMP) family degrades the extracellular matrix. One member of this family, MMP-1, initiates the breakdown of interstitial collagens. The expression ofMMP-1 is controlled by themitogen activated protein kinase (MAPK) pathway(s) via the activity of acti-vator protein-1 (AP-1) and polyoma enhancing activity-3/ E26 virus (PEA3/ETS) transcription factors through con-sensus binding sites present in the promoter.

10p tumor12 20-04-2013 31 2   Download

Earlier we presented several lines of evidence that a 67-kDa laminin binding protein (LBP) inLeishmania donovani,that is different from the putative mammalian 67-kDa laminin receptor, may play an important role in the onset of leish-maniasis, as these parasites invade macrophages in various organs after migrating through the extracellular matrix. Here we describe the membrane orientation of thisLeish-manialaminin receptor.

8p tumor12 20-04-2013 45 4   Download

The cell line, RCS-LTC (derived from the Swarm rat chondrosarcoma), deposits a copious extracellular matrix in which the collagen component is primarily a polymer of partially processed type II N-procollagen molecules. Transmission electron microscopy of the matrix shows no obvious fibrils, only a mass of thin unbanded filaments. We have used this cell system to show that the type II N-pro-collagen polymer nevertheless is stabilized by pyridinoline cross-links at molecular sites (mediated by N- and C-telo-peptide domains) found in collagen II fibrils processed nor-mally....

8p tumor12 20-04-2013 29 1   Download

Pigment epithelium-derived factor (PEDF), a neurotrophic and antiangiogenic protein, is an extracellular component of the retinal interphotoreceptor matrix which has been shown to be secreted by human fetal retinal pigment epithelial cells. It belongs to the serpin superfamily and contains the typical exposed reactive center loop. The functionof this loop is still unknown.

10p tumor12 20-04-2013 30 4   Download

Recently, a new protein containing a disintegrin domain, alternagin-C (Alt-C), was purified fromBothrops alternatus venom. Unlike other disintegrins, in Alt-C an ECD amino acid motif takes the place of the RGD sequence. Most dis-integrins contain an RGD/KGD sequence and are very potent inhibitors of platelet aggregation, as well as other cell interactions with the extracellular matrix, including tumor cell metastasis and angiogenesis. The present study investi-gated the effects of Alt-C on human neutrophil chemotaxis in vitro and the activation of integrin-mediated pathways....

10p fptmusic 12-04-2013 37 2   Download

The urokinase-type plasminogen activator (uPA) receptor (uPAR) has been implicated in signal transduction and biological processes including cancer metastasis, angiogenesis, cell migration, and wound healing. It is a specific cell surface receptor for its ligand uPA, which catalyzes the formation of plasmin from plasminogen, thereby activating the proteolytic cascade that contributes to the breakdown of extracellular matrix, a key step in cancer metastasis.

11p fptmusic 11-04-2013 46 3   Download

The transcription factor Sox9, which is required to establish the chondrocyte lineage, has essential functions at several steps throughout the chondrocyte differentiation pathway. Sox9 is nee-ded at an early step that of mesenchymal condensation. It is then needed for the overt differentiation of chondrocytes in part because Sox9 is required during chondrogenesis for expression of Sox5 and Sox6, which in turn have an essential role at this step. Sox9 also inhibits the maturation of chondrocytes into hyper-trophic chondrocytes. ...

35p fptmusic 11-04-2013 32 3   Download

The dipeptidyl peptidase IV gene family contains the four peptidases dipept-idyl peptidase IV, fibroblast activation protein, dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Dipeptidyl peptidase IV and fibroblast activation protein are involved in cell–extracellular matrix interactions and tissue re-modeling.

14p inspiron33 26-03-2013 40 5   Download

The abundant metabolitemyo-inositol hexakisphosphate (InsP6) can form vesicular deposits with cations, a widespread phenomenon in plants also found in the cestode parasite, Echinococcus granulosus. In this organism, the deposits are exocytosed, accumulating in a host-exposed sheath of extracellular matrix termed the laminated layer.

12p inspiron33 25-03-2013 28 2   Download

Integrins are the major receptor type known to facilitate cell adhesion and lamellipodia formation on extracellular matrix proteins. However, collagen-related peptide and thrombin have recently been shown to mediate platelet lamellipodia formation when presented as immobilized surfaces.

12p inspiron33 23-03-2013 56 2   Download

The dystroglycan adhesion complex consists of two noncovalently interact-ing proteins: a-dystroglycan, a peripheral extracellular subunit that is extensively glycosylated, and the transmembrane b-dystroglycan, whose cytosolic tail interacts with dystrophin, thus linking the F-actin cytoskele-ton to the extracellular matrix.

15p inspiron33 23-03-2013 35 4   Download

Chitinase-like proteins have been identified in insects and mammals as non-enzymatic members of the glycoside hydrolase family 18. Recently, the first molluscan chitinase-like protein, namedCrassostrea gigas(Cg)-Clp1, was shown to control the proliferation and synthesis of extracellular matrix components of mammalian chondrocytes.

9p galaxyss3 19-03-2013 43 4   Download

Snake venom metalloproteinases (SVMPs) have recently been shown to interact with proteins containing von Willebrand factor A (VWA) domains, including the extracellular matrix proteins collagen XII, collagen XIV, mat-rilins 1, 3 and 4, and von Willebrand factor (VWF) via their cysteine-rich domain.

11p galaxyss3 19-03-2013 42 4   Download