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Fatty acid amide hydrolase
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The 2-benzoylbenzoxazole derivatives were known for their significant biological activities such as antiproliferative activity, inhibition of FAAH enzyme (fatty acid amide hydrolase). In this study, we report a simple and efficient method for the synthesis of such compounds by the direct reaction of o-aminophenol with acetophenone catalyzed by sulfur in DMSO.
8p
vimclaren
12-10-2022
7
2
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Previously, we performed analysis of gene expression in 46 axillary lymph node negative tumors and identified molecular gene signatures that resulted in different clinical outcomes. The aim of this study was to determine the correlation of γ-glutamyl hydrolase (GGH), fatty acid amide hydrolase (FAAH), Pirin (PIR) and TAF5-like RNA polymerase II.
12p
vijisoo2711
29-09-2020
10
0
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Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in several blood immune cells, including monocytes/macrophages, basophils and lymphocytes. However, their presence in dendritic cells, which play a key role in the initiation and development of the immune response, has never been investigated.
8p
system191
01-06-2013
24
2
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We have shown recently that in human T lymphocytes, leptin stimulates activity and expression of the endocan-nabinoid-degrading enzyme fatty acid amide hydrolase (FAAH), through STAT3 (signal transducer and activator of transcription 3) and its CRE (cAMP response element)-like transcriptional target in the FAAH promoter [Maccar-rone, M., Di Rienzo, M., Finazzi-Agro`,A., &Rossi,A. (2003) J. Biol. Chem. 278, 13318–13324]. We have also shown that progesterone, alone or additively with leptin, up-regulates theFAAHgene in human T-cells, through the Ikaros transcription factor [Maccarrone, M.
11p
awards
05-04-2013
35
2
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Endogenous levels of the endocannabinoid anandamide, and the activities of the synthesizing and hydrolyzing enzymes, i.e.N-acylphosphatidyletha-nolamine-hydrolyzing phospholipase D and fatty acid amide hydrolase, respectively, were determined in the cortex and the striatum of rats sub-jected to transient middle cerebral artery occlusion.
12p
media19
04-03-2013
23
1
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