Synthesis and cytotoxicity evaluation of 2-benzoylbenzoxazoles by reaction of o-aminophenol with acetophenone catalyzed by sulfur in DMSO

The 2-benzoylbenzoxazole derivatives were known for their significant biological activities such as antiproliferative activity, inhibition of FAAH enzyme (fatty acid amide hydrolase). In this study, we report a simple and efficient method for the synthesis of such compounds by the direct reaction of o-aminophenol with acetophenone catalyzed by sulfur in DMSO.