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Significant biological activities
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Ten new chromone derivatives were synthesized from the original 2-4-6- trihydroxyacetophenone using microwave irradiation. The product's structures were confirmed by FT-IR, 1H-NMR, and 13C-NMR spectra data. The anti-microbial activities of the obtained compounds were tested by the disc diffusion method. The results showed that most chromones have significant biological activities against Candida albicans.
10p
viambani
18-06-2024
1
0
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In this study, we synthesized magnetic activated carbon (MAC) derived from Litsea glutinosa seeds, which was applied to eliminate methylene blue and nickel ions in the aeration tank of the biological treatment system. Structural characteristics and adsorption properties of MAC were studied. The obtained results revealed that the removal efficiency of these pollutants significantly improved as a combination of MAC and activated sludge, especially in the case of nickel ions removal.
7p
dianmotminh02
03-05-2024
2
1
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The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors.
19p
vioraclene
31-03-2024
3
2
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Ebook "Progress in the chemistry of organic natural products: Volume 94" review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.
269p
manmanthanhla0201
26-02-2024
2
1
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Our previous studies have identified CA916798 as a chemotherapy resistance-associated gene in lung cancer. However, the histopathological relevance and biological function of CA916798 in lung adenocarcinoma (LUAD) remains to be delineated. In this study, we further investigated and explored the clinical and biological significance of CA916798 in LUAD.
13p
vischultz
20-10-2023
5
1
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MicroRNAs (miRNAs) have been reported to serve as potential biomarkers in bladder cancer and play important roles in cancer progression. This study aimed to investigate the biological role of miR-205-3p in bladder cancer. We showed that miR-205-3p was significantly down-regulated in bladder cancer tissues and cells.
13p
visharma
20-10-2023
2
2
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Insulin-like growth factor binding protein 5 (IGFBP5) is the highest conserved member of IGFBP family, and has the broad range of biological activities effecting on the cell growth. This study aims to investigate the association between genetic variation in IGFBP5 gene and the growth of striped catfish (Pangasianodon hypophthalmus).
11p
vimulcahy
18-09-2023
4
3
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The 2-benzoylbenzoxazole derivatives were known for their significant biological activities such as antiproliferative activity, inhibition of FAAH enzyme (fatty acid amide hydrolase). In this study, we report a simple and efficient method for the synthesis of such compounds by the direct reaction of o-aminophenol with acetophenone catalyzed by sulfur in DMSO.
8p
vimclaren
12-10-2022
7
2
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RNA degradation affects RNA-seq quality when profiling transcriptional activities in cells. Here, we show that transcript degradation is both gene- and sample-specific and is a common and significant factor that may bias the results in RNA-seq analysis. Most existing global normalization approaches are ineffective to correct for degradation bias.
18p
vigalileogalilei
27-02-2022
8
1
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The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can induce significant levels of unintended mutations at near-cognate sites, necessitating substantial efforts toward the development of strategies to minimize off-target activity.
25p
vigalileogalilei
27-02-2022
15
1
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High-fidelity SpCas9 variants (eSpCas9 and SpCas9-HF1) have been engineered to reduce off-target effects. We found that changes in guide RNA length induced significant reductions in the editing activities of SpCas9 variants in plant cells.
7p
vialfrednobel
29-01-2022
13
0
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Understanding the contributions of transcription factor DNA binding sites to transcriptional enhancers is a significant challenge. We developed Quantitative enhancer-FACS-Seq for highly parallel quantification of enhancer activities from a genomically integrated reporter in Drosophila melanogaster embryos. We investigate the contributions of the DNA binding motifs of four poorly characterized TFs to the activities of twelve embryonic mesodermal enhancers.
24p
viarchimedes
26-01-2022
10
0
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The disturbance in the carbohydrate level was expressed by impairment in the activity of carbohydrate enzymes in treated 2nd and 4th instar larvae. In both treated instar larvae there was a significant increase in the enzyme activity of alpha and beta esterase as well as in glutathione S-transferase.
6p
schindler
30-12-2021
11
0
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The characterization of the biological properties of Chilean polyfloral honey was centered on their antioxidant and antibacterial activities. For this purpose, a significant number of samples were selected to evaluate their biological properties. Additionally, the identification of honey constituents was carried out using a complementary mass spectrometry technique (GC–MS), which allowed to find some 25 different compounds in the analyzed honey.
10p
schindler
30-12-2021
12
0
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The antimicrobial activity of the products was evaluated and the results revealed that compounds 8f and 15f showed strong activity against gram-positive bacteria while compound 15d showed the highest activity against gramnegative bacteria. Moreover, compounds 15b, 8d, 8e, 8c, 8l, and 8j exhibited significant antifungal activity. In addition, the antitumoral activity of the synthesized products against different cancer cell lines was determined and the results revealed that compound 12c was the most active against MCF-7, HepG-2, HCT-116, and HeLa with IC50 values of 0.51, 0.72, 0.95, and 0.
22p
langthannam
29-12-2021
14
0
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Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures confirmed by mass and 1H and 13C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, antaflatoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4-methyl-2-oxo-2 H -chromen-7-yl)oxy)methyl)- 2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,4-phenylene diacetate showed significant antioxidant and antibacterial activity on B. subtilis.
25p
tudichquannguyet
29-11-2021
7
1
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The designed catalyst has shown an enzyme-like kinetics profile with a significant substrate affinity. The cooperative action in between catalytic triad amino acids has shown improved catalytic activity in comparison to only the histidine-containing control group. Histidine is an irreplaceable contributor to catalytic action and this is an additional reason for control group selection. This new method based on the self-assembly of covalently conjugated action units offers a new platform for enzyme investigations and their further applications.
9p
tudichquannguyet
29-11-2021
8
1
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Despite significant limitations of growth medium reuse, a large amount of organic substrate is reused in soilless cultivation of horticultural crops in China. Arbuscular mycorrhizal fungi (AMF) can promote nutrient absorption and improve plant tolerance to biotic and abiotic stresses.
12p
vijichea2711
28-05-2021
12
1
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Mitogen-activated protein kinase kinase kinases (MAPKKKs) are significant components in the MAPK signal pathway and play essential roles in regulating plants against drought stress. To explore MAPKKK gene family functioning in cotton response and resistance to drought stress, we conducted a systematic analysis of GhMAPKKKs.
14p
vijichea2711
28-05-2021
11
1
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Drug discovery and development has been aided by high throughput screening methods that detect compound effects on a single target. However, when using focused initial screening, undesirable secondary effects are often detected late in the development process after significant investment has been made.
11p
vikentucky2711
26-11-2020
8
0
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