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Fatty Liver Disease
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Immunotherapy based on the application of immune checkpoint inhibitors (ICIs) is one of the standard treatments for advanced non-small cell lung cancer (NSCLC). Non-alcoholic fatty liver Disease (NAFLD) has demonstrated predictive value for response to immunotherapy in non-lung cancer types.
10p
vishanshan
27-06-2024
2
1
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Hepatocellular Carcinoma (HCC) can be classified as one of the most common malignancies worldwide. There is scarcity of the published data on the risk factors for HCC in the Gulf Cooperation Council countries specifically Kuwait. Therefore, this case-control study sought to examine the risk factors associated with HCC in Kuwait.
14p
vikoch
27-06-2024
1
1
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The gut-liver axis plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC). However, the correlations between the gut microbiome and the liver tumor transcriptome in patients with HCC and the impact of the gut microbiota on clinical outcome are less well-understood.
14p
vibransone
28-03-2024
3
2
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A limited number of studies have characterized genomic properties of hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods: Herein, we performed comprehensive molecular characterization of immediate (D-42 to D-1) pretreatment tumor biopsy specimens from 60 patients with sorafenib-failed HCC in a single-arm prospective phase II trial of pembrolizumab.
15p
vibransone
28-03-2024
4
2
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Part 2 book "Periparturient diseases of dairy cows - A systems biology approach" includes content: Retained placenta - a systems veterinary approach; omic approaches to a better understanding of mastitis in dairy cows; laminitis - a multisystems veterinary perspective with omics technologies; ketosis under a systems veterinary medicine perspective; the omics side of fatty liver - a holistic approach for a commonly occurring peripartal disease; milk fever - reductionist versus systems veterinary approach.
154p
muasambanhan02
25-12-2023
4
1
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Nonalcoholic fatty liver disease affects about 24% of the world’s population and may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). While more common in those that are obese, NASH-HCC can develop in lean individuals. The mechanisms by which HCC develops and the role of epigenetic changes in the context of obesity and normal weight are not well understood.
13p
vileonardodavinci
23-12-2023
4
2
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Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse symptoms of NASH. In view of these observations, and the fact that NASH is a progressive disease leading to HCC, we hypothesized that saroglitazar may prevent the development of HCC in rodents.
13p
vileonardodavinci
23-12-2023
6
2
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Breast cancer is a major health burden for women, worldwide. Lifestyle-related risk factors, such as obesity and being overweight, have reached epidemic proportions and contributes to the development of breast cancer.
15p
vileonardodavinci
23-12-2023
5
3
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Determine the proportion of NAFLD patients with carotid intima-media thickness (CIMT) ≥ 0.8 mm. Investigation of the correlation between the hepatic steatosis and liver fibrosis by FibroScan - CAP with CIMT in NAFLD patients. Determination of predictive risk factors of CIMT ≥ 0.8 mm in NAFLD patients.
9p
vigeorge
06-12-2023
2
1
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The use of regorafenib in the treatment of hepatocellular carcinoma (HCC) is widespread. Albumin-Bilirubin (ALBI) has been shown to be a potential prognostic marker for regorafenib treatment, but its prognostic value remains controversial.
10p
visharma
20-10-2023
5
2
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The accumulation of lipid droplets (LDs) in hepatocytes is the main pathogenesis in nonalcoholic fatty liver disease (NAFLD), which is also the key risk factor for the progression of hepatocellular carcinoma (HCC). LDs behaviors are demonstrated to be associated with HCC advancement, and are tightly regulated by a subset protein localized on the surface of LDs. However, the role of LDs-localized protein in HCC has been rarely investigated.
14p
vioracle
29-09-2023
3
2
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Bệnh gan nhiễm mỡ liên quan chuyển hóa (Metabolic Associated Fatty Liver Disease - MAFLD) là định nghĩa mới được đề xuất bởi hội đồng chuyên gia quốc tế năm 2021 để thay thế cho thuật ngữ bệnh gan nhiễm mỡ không do rượu (Nonalcoholic fatty liver disease - NAFLD) và đã được Hiệp hội nghiên cứu về gan Châu Á - Thái Bình Dương đưa vào hướng dẫn chẩn đoán và điều trị.
14p
vihawkeye
26-05-2023
8
2
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To develop a computer model to predict patients with nonalcoholic steatohepatitis (NASH) using machine learning (ML). The NASHmap model is a convenient and high performing tool that could be used to identify patients likely to have NASH in clinical settings, allowing better patient management and optimal allocation of clinical resources.
7p
vighostrider
25-05-2023
3
2
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Previously, it was shown that the HFE gene (associated with human hereditary hemochromatosis) has several haplotypes of intronic polymorphisms. Some haplotype frequencies are race specific and hence can be used in phylogenetic analysis.
13p
vinarcissa
21-03-2023
2
1
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Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established from SM/J and A/J strains. We have previously identified Fl1sa, a quantitative trait locus (QTL) for fatty liver on chromosome 12 (centromere-53.06 Mb) of SMXA-5 mice.
10p
vinarcissa
21-03-2023
1
1
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The Silymarin milk thistle tea bag is produced from four herbal plants in Phu Tho province, including Silybum marianum, Celastrus hindsii, Solanum procumbens, and Stevia ribaudiana. Tea products are used as a functional drink to prevent and treat liver diseases such as liver cirrhosis, non-alcoholic fatty liver, steatohepatitis, and alcoholic fatty liver diseases.
7p
vistephenhawking
20-04-2022
11
2
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Nuts are nutrient-rich and reported to provide some cognitive and cardiometabolic health benefits, but limited studies have focused on older adults. This study investigated the cross-sectional relationship between habitual nut intake, dietary pattern and quality, cognition and non-alcoholic fatty liver disease (NAFLD) in older adults.
12p
vinobelprisen
26-03-2022
14
4
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Non-alcoholic fatty liver disease (NAFLD) is represented as the most common liver disease worldwide. NAFLD is associated with metabolic risk factors underpinned by insulin resistance, inflammation and endothelial dysfunction, leading to extrahepatic changes in central nervous diseases such as cognitive impairment, Alzheimer’s disease and dementia. The aim of the review is to explore the association between NAFLD and cognitive function.
19p
vinobelprisen
26-03-2022
17
5
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Recent studies have suggested the significant relationship between follicle-stimulating hormone (FSH) and non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. However, it is unknown whether FSH impacts the risk of NAFLD in men.
10p
vinobelprisen
26-03-2022
10
4
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Histone modification plays essential roles in hepatocellular carcinoma (HCC) pathogenesis, but the regulatory mechanisms remain poorly understood. In this study, we aimed to analyze the roles of Megakaryoblastic leukemia 1 (MKL1) and its regulation of COMPASS (complex of proteins associated with Set1) in HCC cells.
11p
vimahuateng
26-11-2021
10
0
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