![](images/graphics/blank.gif)
Fibroblast cells
-
This study evaluated the clinical relevance of a set of five serum-derived circulating microRNAs (miR‑ NAs) in colorectal cancer (CRC). Additionally, we investigated the role of miR-20a-5p released by exosomes derived from cancer-associated fibroblasts (CAFs) in the context of CRC.
16p
vishanshan
27-06-2024
1
1
Download
-
Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.
15p
vishanshan
27-06-2024
1
1
Download
-
Papillary thyroid carcinoma (PTC) is globally prevalent and associated with an increased risk of lymph node metastasis (LNM). The role of cancer-associated fibroblasts (CAFs) in PTC remains unclear
15p
vikoch
27-06-2024
2
1
Download
-
Extracellular vesicles (EVs) have been revealed to facilitate the development of oral squamous cavity cell carcinoma (OCSCC), while its supporting role in lymph node metastases is under continuous investigation. This study aimed to examine the function of cancer-associated fibroblasts (CAF)-derived EVs (CAF-EVs) during lymph node metastasis in OCSCC and the mechanisms.
13p
vikoch
27-06-2024
2
1
Download
-
Ebook "p53 Protocols (Second edition)" expert researchers in the field detail many of the methods that address the challenging questions of the p53 field. These methods include the identification of the target genes and binding partners of gain of function p53 mutants, methods to determine stress response, autophagy or senescence induced by p53, cell cycle analysis, analysis of different phases of DNA replication modified by p53, and generation of pluripotent stem cells.
251p
dongmelo
27-05-2024
3
2
Download
-
Synovial fibroblasts (SFs) are specialized cells of the synovium that provide nutrients and lubricants for the proper function of diarthrodial joints. Recent evidence appreciates the contribution of SF heterogeneity in arthritic pathologies. However, the normal SF profiles and the molecular networks that govern the transition from homeostatic to arthritic SF heterogeneity remain poorly defined.
25p
viellison
28-03-2024
7
2
Download
-
Recent studies using single-cell transcriptomic analysis have reported several distinct clusters of neo‑ plastic epithelial cells and cancer-associated fibroblasts in the pancreatic cancer tumor microenvironment. However, their molecular characteristics and biological significance have not been clearly elucidated due to intra- and intertumoral heterogeneity.
18p
vicwell
29-02-2024
3
1
Download
-
Dermal Papilla Cells (DPCs) are mesenchymal cells residing at the base of the hair follicles. They play an important role in the hair cycle remodeling and hair follicle regeneration. In conclusion, the protocol is established to isolate and culture DPCs from hair follicle bulbs, and ALP activity is suggested as the major marker for distinguishing DPCs and human fibroblasts.
9p
vigojek
02-02-2024
4
1
Download
-
Part 1 book "Mouse cell culture - Methods and protocols" includes content: The culture of mouse embryonic stem cells and formation of embryoid bodies; derivation of primary mouse embryonic fibroblast (PMEF) cultures; embryonic skeletal muscle microexplant culture and isolation of skeletal muscle stem cells; ... and other contents.
119p
muasambanhan04
07-01-2024
9
1
Download
-
Less than 11% of pancreatic cancer patients survive 5-years post-diagnosis. The unique biology of pancreatic cancer includes a significant expansion of its desmoplastic tumor microenvironment, wherein cancerassociated fibroblasts (CAFs) and their self-produced extracellular matrix are key components.
17p
vileonardodavinci
23-12-2023
4
2
Download
-
CAFs (cancer-associated fibroblasts) and tumor-associated p-EMT (partial epithelial mesenchymal transition) cells coexist and contribute to the formation of epithelial tumors like OSCC (oral squamous cell carcinoma).
8p
vikissinger
21-12-2023
3
1
Download
-
Due to the high drug resistance of hepatocellular carcinoma (HCC), sorafenib has limited efcacy in the treatment of advanced HCC. Cancer-associated fibroblasts (CAFs) play an important regulatory role in the induction of chemoresistance. This study aimed to clarify the mechanism underlying CAF-mediated resistance to sorafenib in HCC.
11p
vileonardodavinci
23-12-2023
5
2
Download
-
Most patients diagnosed with head and neck tumor will present with locally advanced disease, requiring multimodality therapy. Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived signals, such as inflammatory cytokines and growth factors.
10p
vileonardodavinci
23-12-2023
6
2
Download
-
As the dominant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in tumor progression. An increasing number of studies have confirmed that CAFs are involved in almost every aspect of tumors including tumorigenesis, metabolism, invasion, metastasis and drug resistance, and CAFs provide an attractive therapeutic target.
15p
vischultz
20-10-2023
5
2
Download
-
Extranodal extension (ENE) is an adverse prognostic factor for oral squamous cell carcinoma (OSCC), and patients with OSCC along with ENE require neck dissection. In this study, we developed a novel ENE histologybased pathological predictor using MMP14 expression patterns in small biopsy specimens.
14p
vischultz
20-10-2023
1
1
Download
-
Several clear cell renal cell carcinoma (ccRCC) cases harbour fibroblast growth factor receptor 4 (FGFR4) gene copy number (CN) gains. In this study, we investigated the functional contribution of FGFR4 CN amplification in ccRCC.
11p
vischultz
20-10-2023
3
1
Download
-
Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcinoma (OSCC). However, a lack of comprehensive molecular biological analysis leaves the regulatory mechanisms of CAFsExo in OSCC unclear.
14p
visharma
20-10-2023
2
2
Download
-
Part 2 book "Mouse genetics - Methods and protocols" includes content: Isolation and handling of mouse embryonic fibroblasts, generation of induced pluripotent stem cells from mouse adipose tissue, generation of transgenic mouse fluorescent reporter lines for studying hematopoietic development, generation of transgenic mice by exploiting spermatogonial stem cells in vivo,.... and other contents
232p
oursky06
17-10-2023
5
3
Download
-
This study aimed to assess the effects of simulated microgravity (SMG) on senescent human fibroblasts (HFs). The HFs were treated with 150 µM H2O2 in a culture medium for 90 minutes for senescent induction. The senescent HFs were induced SMG for 72 hours by a Gravity simulator, while the control group was treated in the same CO2 incubator.
8p
vicaptainmarvel
21-04-2023
5
2
Download
-
This study investigated the in vitro effects of ZnO NP and chemical UV filters commonly used sunscreens on the function of immortalised and primary skin cells. ZnO particulates (30 nm, 80 nm and 200 nm) were compared to the chemical UV filters: butylmethoxydibenzoylmethane (BMDBM) ethylhexylmethoxycinnamate (EHMC), ethylhexylsalicylate (EHS), homomenthylsalicylate (HMS) and 4-methylbenzylidenecamphor (MBC). Human epidermal keratinocytes (NHEK), epidermal melanocytes (NHEM), dermal fibroblasts (NHDF) and the immortalised keratinocyte HaCaT cell line were used in this study.
324p
runthenight05
01-03-2023
5
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)