Filtering false positive samples

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Intersect-then-combine approach: Improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers

In this study we generated a whole exome sequencing benchmark dataset using the platinum genome sample NA12878 and developed an intersect-then-combine (ITC) approach to increase the accuracy in calling single nucleotide variants (SNVs) and indels in tumour-normal pairs. We evaluated the effect of alignment, base quality recalibration, mutation caller and filtering on sensitivity and false positive rate.

11p vioraclene 31-03-2024 4 2 Download

Improving predicted residue-residue contacts by filtering false positive samples

Research on the residue-residue contacts in interactive proteins is meaningful in determining the function and structure of proteins, structure-based drug design, and disease treatment. Previous methods showed good predicted results, however, the number of false positive non-residue-residue contacts (nonRRCs) is still much higher than the number of true positive residue-residue contacts (RRCs). In this research, we propose a method to eliminate false positive non-RRCs enhancing the predicted quality.

9p nguathienthan6 06-07-2020 10 0 Download