First derivative

Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of these ovarian cancers, the 5-year overall survival rate remains around 45%.

9p vikoch 27-06-2024 1 1   Download

In this study, human induced pluripotent stem cells (hiPSCs) were successfully differentiated into cardiomyocytes and subsequently used to generate spheroids via the hanging drop method. We comprehensively characterized the formation, fusion, and beating capability of the generated spheroids.

11p viambani 18-06-2024 1 0   Download

In this study, soil samples around Nam Son municipal waste disposal site were collected and analyzed 16 typical PAHs in order to determine the pollution level for cropland and the PAHs origin in this area. To the best of our knowledge, this is the first study on organic matter pollution such as PAHs in paddy soil near the Soc Son solid waste treatment complex.

14p viamancio 04-06-2024 2 0   Download

This work uses the finite element method for the first time to simulate the dynamic response of nanoplates resting on a two-parameter elastic foundation under the flexoelectric effect. The calculation formulas are derived from the new type of the shear deformation theory, which is a simple shear deformation theory.

8p dathienlang1012 03-05-2024 1 0   Download

The paper "Dynamic response analysis of nanobeams resting on elastic foundations" uses the finite element method to study the dynamic response of nanobeams resting on an elastic foundation, taking into account the flexoelectricity effect. Timoshenko's first-order shear deformation theory is used to derive the formulations of the beam's forced vibration equation. The proposed theory and mechanical model are verified by comparing the numerical results of this work with those of the published data.

8p dathienlang1012 03-05-2024 3 0   Download

In the present report, a novel concept of frequency response function (FRF) is introduced for piezoelectric beam. First, a model of Timoshenko beam bonded with a piezoelectric layer is established and used for deriving the conventional frequency response function acknowledged as mechanical frequency response function (MERF). Then, the output charge produced in the piezoelectric layer is calculated from the MFRF and therefore obtained frequency-dependent function is called electrical frequency response function (EFRF) for the integrated beam.

16p dianmotminh02 03-05-2024 2 1   Download

In this study, we substitute facial Alq3 with (-Mg) in positions 7 and 5 as electron donating group (EDG) and (-Cl), (-P) and (-S) in position 7 as electron withdrawing groups (EWD). The ground and the first excited states geometries of facial Alq3 and their derivatives are optimized using B3lyp/6-31G (d) methods.

8p dianmotminh02 03-05-2024 2 2   Download

Part 1 book "Thomas’ calculus - Early transcendentals" includes content: Functions, limits and continuity, derivatives, applications of derivatives, integrals, applications of definite integrals, integrals and transcendental functions, techniques of integration, first order differential equations.

585p dianmotminh00 22-04-2024 6 3   Download

In study "Determination of the optimal density contrast in the seafloor depth inversion from gravity anomalies using the Gravity-Geologic method on the central East Sea" the iteration method was applied to determine the optimal density contrast. Firstly, a density contrast is given. Then, the seafloor depths are calculated and compared with the shipborne depths. In the next step, change the density contrast and repeat the calculation. Finally, the optimal density contrast is determined corresponding to the smallest deviation between the gravity anomaly-derived depths and the shipborne depths.

8p tukhauquantuong1011 22-04-2024 2 2   Download

Ebook "Computer simulation of polymeric materials: Applications of the OCTA system" is the first to introduce a mesoscale polymer simulation system called OCTA. With its name derived from "Open Computational Tool for Advanced material technology," OCTA is a unique software product, available without charge, that was developed in a project funded by Japanese government. This volume is strongly recommended as a valuable resource for both academic and industrial researchers who work in polymer simulation.

391p tudohanhtau1006 29-03-2024 6 1   Download

Ebook "Digital simulation in electrochemistry (Fourth edition)" explains how the partial differential equations (pdes) in electroanalytical chemistry can be solved numerically. It guides the reader through the topic in a very didactic way, by first introducing and discussing the basic equations along with some model systems as test cases systematically. Then it outlines basic numerical approximations for derivatives and techniques for the numerical solution of ordinary differential equations. Finally, more complicated methods for approaching the pdes are derived.

500p tudohanhtau1006 29-03-2024 2 1   Download

The study aims to assess the diesel oil adsorption capacity of activated carbon derived from rambutan peel, a prevalent agricultural by-product in Vietnam. The adsorption process will be investigated using various adsorption isotherms (Langmuir, Freundlich, Temkin, Dubin-Radushkevich), adsorption kinetics (pseudo-first order and pseudo-second order).

18p viellison 28-03-2024 4 1   Download

Ebook "Tetramer stability and functional regulation of tumor suppressor protein p53" presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis.

82p coduathanh1122 27-03-2024 1 1   Download

Ebook "Development of novel anti-HIV pyrimidobenzothiazine derivatives" is in three parts. The first part expounds efficient methods for the synthesis of tricyclic heterocycles related to PD 404182 based on the sp2-carbon−heteroatom bond formations. The second part explains SAR studies of PD 404182 for the development of anti-HIV agents. The third part of the thesis elucidates the development of photoaffinity probes for the target identification of PD 404182.

157p coduathanh1122 27-03-2024 2 1   Download

Ebook "Applied thermodynamics for meteorologists" on atmospheric thermodynamics is for students of meteorology or atmospheric science. It also serves as a reference text for working professionals in meteorology and weather forecasting. It is unique because it provides complete, calculus-based derivations of basic physics from first principles, and connects mathematical relationships to real-world, practical weather forecasting applications. Worked examples and practice problems are included throughout.

632p cotieubac1004 15-03-2024 9 0   Download

Ebook "Stem cells in animal species: From pre-clinic to biodiversity" focuses on stem cell research and disease modeling in non-murine species. The book is divided into three parts: Stem Cells for Pre-Clinical Models, Stem Cells in Non-Conventional Species, and Stem Cell Banking for the Future. The first section presents an overview of the different pre-clinical stem cell models recently created in animal species, including the porcine model for heart failure, iPSC in large animal species, Duchenne muscular dystrophy and canine embryo-derived stem cells and modeling for human diseases.

192p manmanthanhla0201 26-02-2024 6 1   Download

Ebook "Bioactive components of milk (Advances in experimental medicine and biology, Volume 606)" is divided into four parts. The first part focuses on bioactive milk lipid components, which very widely among mammalian species. The second part describes different aspects of biological active colostrums and milk proteins and their derivatives, with special concern on species specific effects.

492p manmanthanhla0201 27-02-2024 3 2   Download

Ebook "Food emulsifiers and their applications (Second edition)" has focused on the design and application of emulsifiers as versatile food ingredients. The second edition has updated and expanded applications, from both theoretical and practical perspectives. The first three chapters describe design, synthesis, analysis, and commercial preparation of emulsifiers. Synergistic and antagonistic interactions with other food ingredients, such as carbohydrates, proteins, and water, are discussed in the next three chapters.

433p manmanthanhla0201 27-02-2024 2 1   Download

Ebook "SCIAMACHY - Exploring the changing Earth’s atmosphere" is a comprehensive summary describing the entire SCIAMACHY mission – from the very first ideas to the current results. It illustrates how the measurements are performed, how the trace gas concentrations are derived from the measured spectra and how the unique data sets are used to improve our understanding of the changing Earth’s atmosphere.

238p manmanthanhla0201 27-02-2024 2 1   Download

Increasing evidence suggests that cancer-derived extracellular vesicles (EVs) alter the phenotype and functions of fibroblasts and trigger the reprogramming of normal fibroblasts into cancer-associated fibroblasts (CAFs). Here, we for the first time studied the effects of urinary EVs from PC patients and healthy males on the transcriptional landscape of prostate CAFs and normal foreskin fibroblasts.

12p vialfrednobel 23-12-2023 6 3   Download