Folic acid analogue

Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate is an anti-folate drug that may be prescribed in some malignant or chronic inflammatory conditions.

7p vimax2711 27-03-2020 10 1   Download

Trimethoprim Trimethoprim is a diaminopyrimidine, a structural analogue of the pteridine moiety of folic acid. Trimethoprim is a competitive inhibitor of dihydrofolate reductase; this enzyme is responsible for reduction of dihydrofolic acid to tetrahydrofolic acid—the essential final component in the folic acid synthesis pathway. Like that of the sulfonamides, the activity of trimethoprim is compromised in the presence of exogenous thymine or thymidine. Inhibition of Nucleic Acid Synthesis or Activity Numerous antibacterial compounds have disparate effects on nucleic acids.

7p colgate_colgate 21-12-2010 60 2   Download