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Functional validation
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Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it is vital to determine the prognostic value and therapy response of PCD-related genes in OC.
17p
vishanshan
27-06-2024
1
1
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This research aimed to create a robust signature with hypoxia-related genes to predict the prognosis of breast cancer patients. The function of hypoxia genes was further studied through cell line experiments.
12p
vishanshan
27-06-2024
3
1
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Tumor morphology, immune function, inflammatory levels, and nutritional status play critical roles in the progression of intrahepatic cholangiocarcinoma (ICC). This multicenter study aimed to investigate the association between markers related to tumor morphology, immune function, inflammatory levels, and nutritional status with the prognosis of ICC patients.
16p
vishanshan
27-06-2024
1
1
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Observational studies and clinical validation have suggested a link between thyroid dysfunction and an elevated ovarian cancer (OC) risk. However, whether this association indicates a cause-and-effect relationship remains uncertain. We aimed to investigate the plausible causal impact of thyroid dysfunction on OC through a Mendelian randomization (MR) study.
7p
vishanshan
27-06-2024
1
1
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Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of these ovarian cancers, the 5-year overall survival rate remains around 45%.
9p
vikoch
27-06-2024
1
1
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NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types.
22p
vikoch
27-06-2024
3
1
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Analysed the quantitative data by SPSS and the results show 2 factors affect the performance namely GSCM Benefits and Critical Success factor. Consumer safety contributed significantly in GSCM benefits while, high satisfaction of customers and business partners in SCs contributed significantly in critical success factor.
6p
longtimenosee10
26-04-2024
3
1
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This study aimed to develop a valid and reliable instrument that measures the functional vision of students with low vision. Thus, an assessment tool and performance activities were developed for three vision skill groups (near vision skills, distance vision skills, and visual field) that include functional vision skills.
15p
viarnault
25-04-2024
1
1
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This paper concerns a problem of finite-time stability for a class of linear singular large-scale systems with delays. Based on matrix transformations, Lyapunov function method combined with new estimation techniques, we derive sufficient conditions for solving the finite-time stability of the system. A numerical example is given to illustrate the validity and effectiveness of the theoretical results.
11p
vijaychest
24-04-2024
7
2
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Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized.
22p
vibransone
28-03-2024
2
2
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In this work, we investigate the validation of the even-to-odd universality helium atom consisting of two electrons, applying the time-dependent density functional theory. The results demonstrate that the multielectron effect manifesting through the repulsive Coulomb and exchange-correlation interactions does not considerably change the universality of the even-to-odd ratio of the helium atom.
13p
vimichaelfaraday
28-12-2023
7
3
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Pancreatic cancer (PC) is a highly malignant tumor featured with high intra-tumoral heterogeneity and poor prognosis. Cell-in-cell (CIC) structures have been reported in multiple cancers, and their presence is associated with disease progression. Nonetheless, the prognostic values and biological functions of CIC-related genes in PC remain poorly understood.
24p
vialfrednobel
23-12-2023
7
5
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Ebook "Excel university: Microsoft Excel training for CPAs and accounting professionals (Volume 1)" offers a comprehensive collection of the features, functions, and techniques that are of direct benefit to accountants working in industry, public practice, consulting, or not-for-profit. In Volume 1, the author presents material and information that will prove useful to every accountant, regardless of the type of work they do.
185p
mocthanhdao0210
19-11-2023
7
4
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Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC development and progression is not well understood. Methods We sought to establish a dynamic Chinese hamster OSCC animal model, construct miRNA differential expression profiles of its occurrence and development, predict its targets, and perform functional analysis and validation in vitro.
19p
vischultz
20-10-2023
6
2
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Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive malignant tumors. Chromobox (CBX) family plays the role of oncogenes in various malignancies. Methods The transcriptional and protein levels of CBX family were confirmed by GEPIA, Oncomine, CCLE, and HPA database. Screening of co-expressed genes and gene function enrichment analysis were performed by GeneMANIA and DAVID 6.8.
17p
vioracle
29-09-2023
9
2
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Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the status and function of immune infltration in the glioma microenvironment must be explored.
18p
vioracle
29-09-2023
6
3
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Studies have demonstrated that Sorting nexin 7 (SNX7) functions as an anti-apoptotic protein in liver tissue and plays a crucial role in the survival of hepatocytes during early embryonic development.
17p
vioracle
29-09-2023
5
2
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MetaMap is a widely used named entity recognition tool that identifies concepts from the Unified Medical Language System Metathesaurus in text. This study presents MetaMap Lite, an implementation of some of the basic MetaMap functions in Java.
4p
visteverogers
24-06-2023
5
2
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Ebook Principles of software engineering: Part 1 presents the following content: Introduction to Software Engineering; Software Processes and Models; Software Requirements; Introduction to Validation, Metrics; Software Project Planningdeo; Functional Design;...Please refer to the documentation for more details.
165p
chankora
16-06-2023
3
2
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A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes
Cox-regression-based methods have been commonly used for the analyses of survival outcomes, such as age-at-disease-onset. These methods generally assume the hazard functions are proportional among various risk groups. However, such an assumption may not be valid in genetic association studies, especially when complex interactions are involved. In addition, genetic association studies commonly adopt case-control designs.
11p
vinarcissa
21-03-2023
5
1
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