Gastrointestinal therapeutics
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Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.
15p vishanshan 27-06-2024 1 1 Download
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p vikoch 27-06-2024 1 1 Download
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Part 2 book "Goodman and gilmans the pharmacological basis of therapeutics" includes content: Hormones and hormone antagonists, gastrointestinal pharmacology, chemotherapy of infectious diseases, pharmacotherapy of neoplastic disease, special systems pharmacology.
649p zizaybay1101 30-04-2024 4 2 Download
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Part 1 book "Rebhun’s diseases of dairy cattle" includes content: The clinical examination; therapeutics and routine procedures, cardiovascular diseases; respiratory diseases; noninfectious diseases of the gastrointestinal tract; infectious diseases of the gastrointestinal tract; skin diseases.
397p muasambanhan04 07-01-2024 4 1 Download
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Part 2 book "Small animal clinical pharmacology and therapeutics" includes content: Opioid analgesics, cancer chemotherapy, anticonvulsant drugs, drugs used in the management of heart disease and cardiac arrhythmias, drugs used in the management of respiratory diseases, gastrointestinal drugs, drugs used in the treatment of adrenal dysfunction.
418p muasambanhan03 25-12-2023 2 1 Download
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Part 2 book "Immunity to parasitic infection" includes content: Introduction to helminth infections, malaria and schistosomes, gastrointestinal nematodes and malaria, hygiene and other early childhood influences on the subsequent function of the immune system, nematodes as therapeutic organisms, vaccination against malaria,... and other contents.
308p oursky05 20-09-2023 5 2 Download
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Part 2 book "Equine pharmacology" includes content: Clinical pharmacology of the respiratory, clinical application of gastrointestinal therapeutics, treatment of equine nervous system disorders, therapy of the eye, equine cardiovascular clinical pharmacology, clinical pharmacology of diseases of the equine urinary system,... and other contents.
185p oursky04 14-09-2023 4 2 Download
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This Master by Research project aims to develop the human gas capsule that enables realtime intestinal gas profiling in a low-cost, non-invasive and accurate manner. The safety, viability, reliability and repeatability of the capsule will be evaluated in both laboratorial environments and animal trials that are influenced by dietary effect, heat-stress-induced gut disorder and dietary supplemental therapeutic agent.
104p runthenight04 02-02-2023 4 1 Download
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The recent identification of the endocannabinoid system in the gastrointestinal tract suggests a role in controlling intestinal inflammation. In addition, the gut chemosensing system has therapeutic applications in the treatment of gastrointestinal diseases and inflammation due to the presence of a large variety of receptors.
11p vigandhi 23-02-2022 7 1 Download
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Propofol sedation is effective for gastrointestinal endoscopic procedures, but its narrow therapeutic window highlights the importance of identifying an optimal administration technique regarding effectiveness and safety. This study aimed to determine the incidence of significant adverse events in adult patients scheduled for gastrointestinal endoscopy under anaesthetist-performed sedation using propofol target-controlled infusion and determine the existence of associations between these events and potentially related variables.
8p vizhangzhidong 29-12-2021 10 0 Download
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In 2017, World Health Organization (WHO) published a catalogue of 12 families of antibiotic-resistant “priority pathogens” that are posing the greatest threats to human health. Six of these dreaded pathogens are known to infect the human gastrointestinal system.
16p vijeeni2711 24-07-2021 9 0 Download
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The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales.
9p virose2711 24-09-2020 14 1 Download
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Pancreatic cancer, one of the most dreadful gastrointestinal tract malignancies, with the current chemotherapeutic drugs has posed a major impediment owing to poor prognosis and chemo-resistance thereby suggesting critical need for additional drugs as therapeutics in combating the situation.
15p viamsterdam 18-09-2020 10 1 Download
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Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early diagnostic markers and novel therapeutic targets can significantly improve clinical management of gallbladder cancer.
12p vimoscow2711 29-08-2020 6 0 Download
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Ampullary adenocarcinoma is a rare gastrointestinal cancer associated with diverse outcomes due to clinical and pathological heterogeneity. Standardized methods to better prognosticate and inform therapeutic selection for ampullary adenocarcinoma are needed.
11p vimale2711 25-08-2020 6 1 Download
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Patients with upper gastrointestinal malignancy often require admission to hospital with dysphagia or jaundice requiring therapeutic endoscopy. Endoscopic intervention is often effective permitting rapid discharge. An efficient service would permit rapid discharge for patients who are often at the end of life.
5p vidhaka2711 31-07-2020 8 1 Download
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Cholangiocarcinoma, or bile duct cancer, is a gastrointestinal cancer with limited therapeutic options and a poor outcome. Studies have revealed that some major driver genes are associated with cholangiocarcinoma, but no targeted therapies have been approved.
5p vimanila2711 25-06-2020 9 1 Download
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Mosapride belongs to class IV in Biopharmaceutics Classification System and is used in the treatment of reflux esophagitis. It exhibits poor bioavailability due to limited permeability, solubility and extensive first-pass metabolism. In this study, intranasal mosapride-loaded cross-linked xyloglucan Pluronic micelles (MOS-XPMs) was formulated and optimized to improve the low solubility & bioavailability of MOS. The solid dispersion technique using 23 full factorial design was applied. (MOS-XPMs) (F4) had the highest desirability value (0.
12p partimesinhvien 08-05-2020 6 1 Download
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Regional evidence-based guidelines for the prophylaxis and management of infantile colic are not available for the Middle East and North Africa (MENA) region.
7p vidr2711 19-02-2020 9 2 Download
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To explore the changes of inflammatory and oxidative stress responses in Henoch-Schönlein purpura (HSP) children, and further analyzed the therapeutic effects and mechanisms of hemoperfusion (HP) on HSP with severe gastrointestinal (GI) involvement.
10p virome2711 13-01-2020 8 1 Download