Gene conservation

Classifying pathogenicity of missense variants represents a major challenge in clinical practice during the diagnoses of rare and genetic heterogeneous neurodevelopmental disorders (NDDs). While orthologous gene conservation is commonly employed in variant annotation, approximately 80% of known disease-associated genes belong to gene families.

12p vibransone 28-03-2024 3 2   Download

Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized.

22p vibransone 28-03-2024 2 2   Download

Patterns in expression data conserved across multiple independent disease studies are likely to represent important molecular events underlying the disease. We present the INSPIRE method to infer modules of co-expressed genes and the dependencies among the modules from multiple expression datasets that may contain different sets of genes.

31p vioraclene 31-03-2024 4 2   Download

Part 2 book "Introduction to veterinary genetics" includes content: Pharmacogenetics; Hosts, parasites, and pathogens; Single genes in animal breeding; relationship and inbreeding; quantitative variation; selection between populations; selection within populations, breed structure, crossing, selection and regular crossing; biotechnology and the future; conservation genetics, genetic and environmental control of inherited disorders.

147p muasambanhan06 03-02-2024 7 1   Download

Ebook "Genomics and breeding for climate-resilient crops - Vol. 1: Concepts and strategies" presents the basic concepts and strategies for developing climate-resilient crop varieties. Topics covered include: conservation, evaluation and utilization of biodiversity; identification of traits, genes and crops of the future; genomic and molecular tools; genetic engineering; participatory and evolutionary breeding;...

555p lucchinguyen 28-12-2023 6 3   Download

Ubiquitin-specific protease 32 (USP32) is a highly conserved gene that promotes cancer progression. However, its role in hepatocellular carcinoma (HCC) is not well understood. The aim of this project is to explore the clinical significance and functions of USP32 in HCC.

15p vileonardodavinci 23-12-2023 2 2   Download

S100A16 protein belongs to the S100 family of calcium-binding proteins, which is widely distributed in human tissues and highly conserved. S100 calcium-binding proteins possess broad biological functions, such as cancer cell proliferation, apoptosis, tumor metastasis, and inflammation (Nat Rev Cancer 15:96–109, 2015).

14p vialfrednobel 23-12-2023 4 2   Download

Ethiopia is one of the world centers of genetic diversity and origin of barley crop. Now a day the country is conserve many cereal crops under cold room storage, gene bank. One of the conserved crops is barley. The aim of this study is to evaluate the effects of long term storage factors on nutritional value of barley that tested in 1993 and compare the results with nutritional value of barley that tested after 25 years (2018).

9p viisac 23-09-2023 2 1   Download

Insulin-like growth factor binding protein 5 (IGFBP5) is the highest conserved member of IGFBP family, and has the broad range of biological activities effecting on the cell growth. This study aims to investigate the association between genetic variation in IGFBP5 gene and the growth of striped catfish (Pangasianodon hypophthalmus).

11p vimulcahy 18-09-2023 4 3   Download

The DNA barcodes of COI gene developed in this study could be useful for estimating phylogenetic diversity as well as other studies of gobiids in terms of conservation, management and utilization of fisheries resources in Vietnam. In addition, the results showed the high potentiality in using COI barcode to identify marine fish.

9p vicaptainmarvel 21-04-2023 3 3   Download

In this study, we sequenced the chloroplast gene region (matK) to identify the genetic characteristics of T. chantrieri and their phylogenetic inference in the genus Tacca in Ba Vi National Park (Ba Vi NP). This study contributes to developing a DNA barcode database as a foundation for conservation, evolution, and biological systems.

11p viblackwidow 07-04-2023 11 3   Download

High-density single nucleotide polymorphisms (SNPs) are the most abundant and robust form of genetic variants and hence make highly favorable markers to determine the genetic diversity and relationship, enhancing the selection of breeding materials and the discovery of novel genes associated with economically important traits.

13p vinarcissa 21-03-2023 2 1   Download

Korarima [Aframomum corrorima (Braun) P.C.M. Jansen] is a spice crop native to Ethiopia. Understanding the extent and partitioning of diversity within and among crop landraces and their wild relatives is among the first steps in conserving and measuring their genetic potential. The present study is aimed at characterizing the population genetic structure and relationships between cultivated and wild korarima in the southwestern part of Ethiopia.

13p vinarcissa 21-03-2023 4 1   Download

Allotetraploid F1 hybrids (4nF1) (AABB, 4n = 148) were generated from the distant hybridization of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂). It has been reported that Hox gene clusters are highly conserved among plants and vertebrates. In this study, we investigated the genomic organization of Hox gene clusters in the allotetraploid F1 hybrids and their parents to investigate the polyploidization process.

9p vinarcissa 21-03-2023 3 1   Download

Head spot is one of the phenotypes identified in the KFRS4/Kyo rat strain. Although previous linkage analysis suggested that Ednrb, which is frequently involved in coat color variations in various animals, could be the gene responsible for this phenotype, no mutations have been identified in its coding region.

8p vinarcissa 21-03-2023 3 1   Download

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) and Cerebral Dopamine Neurotrophic Factor (CDNF) form an evolutionarily conserved family of neurotrophic factors. Orthologues for MANF/CDNF are the only neurotrophic factors as yet identified in invertebrates with conserved amino acid sequence.

19p vinarcissa 21-03-2023 2 1   Download

Studying the survival of yeast in stationary phase, known as chronological lifespan, led to the identification of molecular ageing factors conserved from yeast to higher organisms. To identify functional interactions among yeast chronological ageing genes, we conducted a haploproficiency screen on the basis of previously identified long-living mutants.

14p vinarcissa 21-03-2023 1 1   Download

In order to assess genetic diversity of a set of 41 Caricaceae accessions, this study used 34 primer pairs designed from the conserved domains of bacterial leaf blight resistance genes from rice, in a PCR based approach, to identify and analyse resistance gene analogues from various accessions of Carica papaya, Vasconcellea goudotiana, V. microcarpa, V. parviflora, V. pubescens, V. stipulata and, V. quercifolia and Jacaratia spinosa.

14p vinarcissa 21-03-2023 7 1   Download

The novel organic cation transporter 2 (OCTN2) is the physiologically most important carnitine transporter in tissues and is responsible for carnitine absorption in the intestine, carnitine reabsorption in the kidney and distribution of carnitine between tissues. Genetic studies clearly demonstrated that the mouse OCTN2 gene is directly regulated by peroxisome proliferator-activated receptor α (PPARα).

9p vinarcissa 21-03-2023 3 1   Download

Alternative splicing is a widely used mechanism of gene regulation in sex determination pathways of Insects. In species from orders as distant as Diptera, Hymenoptera and Coleoptera, female differentiation relies on the activities of conserved splicing regulators, TRA and TRA-2, promoting female-specific expression of the global effector doublesex (dsx).

6p vinarcissa 21-03-2023 3 1   Download