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Gene dosage
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Part 1 book "Plant epigenetics and epigenomics - Methods and protocols" includes content: Landscaping plant epigenetics, the gene balance hypothesis - dosage effects in plants; inference of allele specific expression from RNA seq data 5 screening for imprinted genes using high resolution melting analysis of PCR amplicons; analysis of genomic imprinting by quantitative allele specific expression by pyrosequencing,... and other contents.
20p
dianmotminh04
12-07-2024
0
0
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Intrachromosomal triplications (TRP) can contribute to disease etiology via gene dosage effects, gene disruption, position effects, or fusion gene formation. Recently, post-zygotic de novo triplications adjacent to copynumber neutral genomic intervals with runs of homozygosity (ROH) have been shown to result in uniparental isodisomy (UPD).
14p
vibransone
28-03-2024
6
2
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X-chromosome inactivation silences one X chromosome in females to achieve dosage compensation with the single X chromosome in males. While most genes are silenced on the inactive X chromosome, the gene for the long non-coding RNA XIST is silenced on the active X chromosome and expressed from the inactive X chromosome with which the XIST RNA associates, triggering silencing of the chromosome.
11p
vinarcissa
21-03-2023
5
1
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We investigated the presence of antibiotic resistance genes in enterococci isolates that were obtained from faecal samples of 3 hospitalized patients receiving antibiotic prophylaxis therapy, and from ileostomy effluent of 1 subject without antibiotic dosage. 16S rRNA gene sequencing and (GTG)-5 PCR were used for classification of Enterococcus spp.
5p
vijaguar
16-11-2022
6
1
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X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the differentiation-promoting MAP kinase (MAPK) signaling pathway, and delaying differentiation.
41p
viarchimedes
26-01-2022
7
0
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Whole genome duplication (WGD) events have played a major role in eukaryotic genome evolution, but the consequence of these extreme events in adaptive genome evolution is still not well understood.
18p
viarchimedes
26-01-2022
9
0
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PAX6 is a homeodomain transcription factor that acts in a highly dosage-sensitive manner to regulate the development and function of the eyes, nose, central nervous system, gut, and endocrine pancreas. Several individual microRNAs (miRNA) have been implicated in regulating PAX6 in different cellular contexts, but a more general view of how they contribute to the fine-tuning and homeostasis of PAX6 is poorly understood.
17p
vitzuyu2711
29-09-2021
11
1
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During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes. The evolutionary resolution to such dosage imbalance, as hypothesized by Susumu Ohno fifty years ago, should be doubling the expression of X-linked genes.
9p
vigiselle2711
30-08-2021
7
1
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Hexaploid bread wheat (Triticum aestivum L) arose by two polyploidisation events from three diploid species with homoeologous genomes. Nullisomic-tetrasomic (nulli-tetra or NT) lines are aneuploid wheat plants lacking two and adding two of six homoeologous chromosomes.
17p
vigiselle2711
30-08-2021
6
1
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Triploid coho salmon are excellent models for studying gene dosage and the effects of increased cell volume on gene expression. Triploids have an additional haploid genome in each cell and have fewer but larger cells than diploid coho salmon to accommodate the increased genome size.
14p
visilicon2711
20-08-2021
9
1
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The genome of Vibrionaceae bacteria, which consists of two circular chromosomes, is replicated in a highly ordered fashion. In fast-growing bacteria, multifork replication results in higher gene copy numbers and increased expression of genes located close to the origin of replication of Chr 1 (ori1).
12p
vijeeni2711
30-06-2021
5
1
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Knock-down of RPL23aA using RNAi impeded growth and led to morphological abnormalities, whereas knock-out of RPL23aB had no observable phenotype, thus these two RPL23a paralogous proteins have been used as examples of ribosomal protein paralogues with functional divergence in many published papers.
11p
vijichea2711
28-05-2021
15
0
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The mouse embryonic mandible comprises two types of tooth primordia in the cheek region: progressive tooth primordia of prospective functional teeth and rudimentary tooth primordia in premolar region – MS and R2. Mice lacking Sprouty genes develop supernumerary tooth in front of the lower M1 (first molar) primordium during embryogenesis.
12p
viwyoming2711
16-12-2020
6
1
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Modules of interacting components arranged in specific network topologies have evolved to perform a diverse array of cellular functions. For a network with a constant topological structure, its function within a cell may still be tuned by changing the number of instances of a particular component (e.g., gene copy number) or by modulating the intrinsic biochemical properties of a component (e.g., binding strength or catalytic efficiency).
12p
vijisoo2711
27-10-2020
9
1
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As a highly efficient and specific gene regulation technology, RNAi has broad application fields and good prospects. The effect of RNAi enhances as the dosage of siRNA increases, while an exorbitant siRNA dosage will inhibit the RNAi effect.
10p
vijisoo2711
27-10-2020
12
1
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Mercaptopurine (6-MP) plays a pivotal role in treatment of childhood acute lymphoblastic leukemia (ALL); however, interindividual variability in toxicity of this drug due to genetic polymorphism in 6-MP metabolizing enzymes has been described.
5p
virose2711
24-09-2020
22
1
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Great advances have been achieved in our understanding of flower development and evolution since the establishment of the ABC model. However, it remains a challenge to define the exact context of organ identity in the component interactions of the ABC model.
16p
viharuno2711
24-04-2020
18
0
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals...
0p
thulanh21
12-11-2011
46
1
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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: AAV-mediated gene therapy for metabolic diseases: dosage and reapplication studies in the molybdenum cofactor deficiency model
0p
toshiba20
12-11-2011
57
1
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Gene-dosage effects in Down syndrome and trisomic mouse models...
4p
thulanh19
09-11-2011
39
2
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