![](images/graphics/blank.gif)
Genetic changes
-
Hepatocellular carcinoma (HCC) genomic research has discovered actionable genetic changes that might guide treatment decisions and clinical trials. Nonetheless, due to a lack of large-scale multicenter clinical validation, these putative targets have not been converted into patient survival advantages.
12p
vikoch
27-06-2024
1
1
Download
-
In this study, we attempted to non-invasively diagnose glioma development and the presence of IDH mutations using multivariate analysis of the plasma mid-infrared absorption spectra for a comprehensive and sensitive view of changes in blood components associated with the disease and genetic mutations.
14p
vikoch
27-06-2024
1
1
Download
-
This article will outline the justification and implications of this taxonomic reclassification for the species formerly known as Cymodocea serrulata. We will examine the reasons for the name change, provide background on the new genus Oceana, and discuss potential impacts on future research. The goal is to clarify why this change was made and what it signifies for our scientific understanding of the species.
9p
dianmotminh02
03-05-2024
4
2
Download
-
Evolution is one of the most difficult and controversial topics. Scientific knowledge of evolution should belong to general knowledge of people, it should be the part of their natural science knowledge or biological education because it is the basis for accepting or refusing of other important topics such as genetical modification, global climatic change and others.
11p
viarnault
25-04-2024
2
1
Download
-
Ebook "Prostate cancer: Biochemistry, molecular biology and genetics" provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer.
517p
tracanhphuonghoa1007
22-04-2024
2
2
Download
-
Part 1 book "Textbook of veterinary pathology - Quick review and self assessment" includes content: Introduction, etiology, genetic disorders, developmental anomalies and monsters, disturbances in growth, disturbances in circulation, disturbances in cell metabolism, necrosis, gangrene and post mortem changes, disturbances in calcification and pigment metabolism, inflammation and healing, concretions, immunity and immunopathology, pathology of cutaneous system, pathology of musculoskeletal systemm,... and other contents.
311p
muasambanhan10
06-04-2024
3
1
Download
-
Part 1 book "The process of animal domestication" by Marcelo R Snchez includes content: Pathways in time and space; domesticated mammals and birds, species accounts; the genetics of domestication; evolutionary development; ontogenetic change.
157p
muasambanhan10
03-04-2024
4
1
Download
-
Part 1 book "Maternal-newborn nursing demystified" by outhor Joyce Y. Johnson, RN, PhD includes content: Overview of maternity nursing; families and communities; health assessment of the pediatric client; pre pregnancy preparation, conception, and genetic considerations; reproductive health issues; physiologic changes of pregnancy.
137p
muasambanhan10
03-04-2024
4
2
Download
-
Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.
22p
vibransone
28-03-2024
3
2
Download
-
One of the major challenges in current psychiatric epigenetic studies is the tissue specificity of epigenetic changes since access to brain samples is limited. Peripheral tissues have been studied as surrogates but the knowledge of cross-tissue genetic-epigenetic characteristics remains largely unknown.
12p
vibransone
28-03-2024
5
2
Download
-
Pulmonary arterial hypertension (PAH) is a rare disease characterized by distinctive changes in pulmonary arterioles that lead to progressive pulmonary arterial pressures, right-sided heart failure, and a high mortality rate.
11p
vibransone
28-03-2024
5
2
Download
-
Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered DNA methylation.
12p
vibransone
28-03-2024
3
2
Download
-
The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from a genetic variant to a complex trait.
15p
vibransone
28-03-2024
4
2
Download
-
Many genetic/genomic disorders are caused by genomic rearrangements. Standard methods can often characterize these variations only partly, e.g., copy number changes or breakpoints. It is important to fully understand the order and orientation of rearranged fragments, with precise breakpoints, to know the pathogenicity of the rearrangements.
17p
vibransone
28-03-2024
3
2
Download
-
The genetic origins of chemotherapy resistance are well established; however, the role of epigenetics in drug resistance is less well understood. To investigate mechanisms of drug resistance, we performed systematic genetic, epigenetic, and transcriptomic analyses of an alkylating agent-sensitive murine lymphoma cell line and a series of resistant lines derived by drug dose escalation.
11p
vioraclene
31-03-2024
2
1
Download
-
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step changes in our understanding of malaria parasite (Plasmodium spp.) biology and its interactions with its host and vector.
17p
vioraclene
31-03-2024
7
2
Download
-
Obesity and type 2 diabetes (T2D) are linked both with host genetics and with environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede disease onset.
14p
vioraclene
31-03-2024
4
2
Download
-
Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and healthy tissues found alterations in patterns of DNA methylation, histone posttranslational modifications, and changes in chromatin accessibility.
12p
vibransone
28-03-2024
7
2
Download
-
Changes in medical practice are needed to improve the diagnosis of monogenic forms of selected common diseases. This article seeks to focus attention on the need for universal genetic testing in common diseases for which the recommended clinical management of patients with specific monogenic forms of disease diverges from standard management and has evidence for improved outcomes.
10p
viellison
28-03-2024
4
2
Download
-
Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Accumulating evidence from genetic studies suggests the importance of phospholipase C γ 2 (PLCG2) in late-onset AD (LOAD) pathophysiology. However, the role of PLCG2 in AD is still poorly understood.
13p
viellison
28-03-2024
5
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)