Genetic differentiation

presents the following content: Chapter 1 introduction, chapter 2 approximation of a function, chapter 3 numerical calculus, chapter 4 ordinary differential equations, chapter 5 numerical methods for matrices, chapter 6 spectral analysis, chapter 7 partial differential equations, chapter 8 molecular dynamics simulations, chapter 9 modeling continuous systems, chapter 10 monte carlo simulations, chapter 11 genetic algorithm and programming, chapter 12 numerical renormalization.

402p zizaybay1103 29-05-2024 3 2   Download

Ebook "Engineering and application of pluripotent stem cells" reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening.

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The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.

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Unraveling functional noncoding variants associated with complex diseases is still a great challenge. We present a novel algorithm, Prioritization And Functional Assessment (PAFA), that prioritizes and assesses the functionality of genetic variants by introducing population differentiation measures and recalibrating training variants.

18p vibransone 28-03-2024 1 1   Download

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylation have not previously been characterised.

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Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation that fuses ETV6 and RUNX1 genes, lead to arrested cell differentiation.

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Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from the left ventricle (LV, n = 76) before and after ischemia, and tested the utility of differential ASE to identify genes associated with postoperative atrial fibrillation (poAF) and myocardial ischemia.

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected 2,214 samples from 30 hospitals in Orange County, California and showed by spa typing that genetic differentiation decreased significantly with increased patient sharing.

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Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and healthy tissues found alterations in patterns of DNA methylation, histone posttranslational modifications, and changes in chromatin accessibility.

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Non-coding regulatory elements (NCREs), such as enhancers, play a crucial role in gene regulation, and genetic aberrations in NCREs can lead to human disease, including brain disorders. The human brain is a complex organ that is susceptible to numerous disorders.

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Multiple computational approaches have been developed to improve our understanding of genetic variants. However, their ability to identify rare pathogenic variants from rare benign ones is still lacking.

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Ebook "Plastid biology (Advances in plant biology, Volume 5)" covers in 21 chapters nearly all actively investigated areas of plastid biology, from biosynthesis to function to their uses in biotechnology. The editors have compiled an extensive list of international experts from whom to solicit chapters. As is evident from the suggested Table of Contents, the book will start with a discussion of genetic material and its expression, followed by differentiation and development of different plastid types and internal organization.

585p cotieubac1004 15-03-2024 1 0   Download

Part 2 book "Multi-objective optimization in chemical engineering" includes content: Parameter estimation in phase equilibria calculations using multi objective evolutionary algorithms, phase equilibrium data reconciliation using multi objective differential evolution with tabu list, ecodesign of chemical processes with multi objective genetic algorithms,...and other contents.

259p muasambanhan09 12-03-2024 0 0   Download

Age and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue function. However, the underlying cellular and genetic factors linking aging and obesity on adipose tissue function have remained elusive.

24p vicwell 29-02-2024 4 2   Download

Ebook "Evolutionary population genetics of drosophila ananassae" introduces readers to classical population genetics and the ways in which it can be applied to practical problems, including testing for natural selection, genetic drift, genetic differentiation, population structuring, gene flow and linkage disequilibrium. It provides a comprehensive monograph on the topic, addressing the theory, applications and evolutionary deductions, which are clearly explained using experimental results.

117p manmanthanhla0201 26-02-2024 2 1   Download

Part 1 book "Mesenchymal stem cell in veterinary sciences" includes content: Introduction to stem cells; mesenchymal stem cell and its properties; mesenchymal stem cell isolation, culture, characterization and cryopreservation; mesenchymal stem cell immuno modulatory and anti inflammatory properties; mesenchymal stem cell differentiation properties and available microenvironment; mesenchymal stem cell genetic engineering and regenerative medicine; sheep mesenchymal stem cell basic research and potential applications.

164p muasambanhan06 03-02-2024 4 1   Download

Part 1 book "Diseases of swine" includes content: Herd evaluation; behavior and welfare; genetics and health; effect of environment on health, differential diagnosis of diseases; diagnostic tests, test performance, and considerations for interpretation; optimizing sample selection, collection, and submission to optimize diagnostic value; collecting evidence and establishing causality; disease control, prevention, and elimination;... and other contents.

396p muasambanhan04 11-01-2024 4 1   Download

Part 1 book "Sex control in aquaculture" includes content: Sex control in aquaculture - concept to practice; sex determination and differentiation in fish - genetic, genomic, and endocrine aspects; epigenetics of sex determination and differentiation in fish; environmental sex determination and sex differentiation in teleosts – how sex is established; gene knockout and its principle and application in sex control of fish species,... and other contents.

410p muasambanhan04 07-01-2024 2 1   Download

Part 1 book "Veterinary genetics and reproductive physiology" includes content: The genetic material, mendelian genetics, simple mendelian patterns of inheritance, cytogenetics, the sex chromosomes and sex differentiation, blood groups and blood typing, inbreeding, cross breeding and heterosis, selection and eradication schemes.

67p muasambanhan02 18-12-2023 4 0   Download

Small intestinal neuroendocrine tumors (SI-NET) are highly differentiated and genetically stable malignant tumors, yet they often present with advanced metastatic spread at the time of diagnosis. In contrast to many other types of malignant tumors, primary SI-NET are often asymptomatic and typically smaller in size compared to adjacent lymph node metastases.

12p vischultz 20-10-2023 5 1   Download