Genetic dispositions

Individual response to medications varies significantly among different populations, and great progress in understanding the molecular basis of drug action has been made in the past 50 years. The field of pharmacogenomics seeks to elucidate inherited differences in drug disposition and effects.

9p vinarcissa 21-03-2023 2 1   Download

In the past decades, China’s rapid economic growth has been accompanied by rapid changes in lifestyle and an increasing prevalence of mental disorders. This study explored the changes and factors associated with depression among the elderly population of China from 2011 to 2018.

11p vinobelprisen 26-03-2022 21 4   Download

Cutaneous adverse reactions (CARs) from antiepileptic drugs (AEDs) are common, ranging from mild to life-threatening, including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The identification of subjects carrying the HLA-B*15:02, an inherited allelic variant of the HLAB gene, and the avoidance of carbamazepine (CBZ) therapy in these subjects are strongly associated with a decrease in the incidence of carbamazepine-induced SJS/TEN. In spite of the strong genetic associations, the initiation of hypersensitivity for AEDs is still not very well characterized.

10p caothientrangnguyen 09-05-2020 10 1   Download

We all know only too well that our way of life, the food we eat, smoking, stress or environmental toxins infl uence our health. But we have just started to learn how these environmental factors cooperate with our hereditary genetic dispositions to determine health or the development of diseases. Moreover, we did not know until recently that all these factors may also infl uence the health of our children and grandchildren to whom we may transmit functional changes of our genes.

322p cronus75 14-01-2013 49 2   Download

Because death rate increases with age, stroke mortality is highest among elderly women. In 2005 the death rate from stroke for women over 65 varied from highs of 1,276.55/100,000 in Latvia and 874.43/100,000 in Lithuania to lows of 218.44/100,000 in France and 297/100,000 in Iceland (WHO 2009a). There are a number of known risk factors for cardiovascular diseases in women.

14p quygia123 06-11-2012 48 0   Download

General symptoms include morning stiffness of more than 60 minutes, fatigue, sometimes even slightly elevated temperature, but the main initial symptom is low back pain at night and in the morning. All patients with low back pain should be questioned about a positive family history concerning rheumatic diseases, as the risk of developing this illness is higher in patients where family members already have been diagnosed with ankylosing spondylitis.

366p wqwqwqwqwq 23-07-2012 77 9   Download