Genetic inhibition

The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated breast or ovarian cancer.

12p vibransone 28-03-2024 3 2   Download

The respiratory pathogen Streptococcus pneumoniae (the pneumococcus) is a genetically diverse bacterium associated with over 101 immunologically distinct polysaccharide capsules (serotypes).

23p vicwell 29-02-2024 1 1   Download

Ebook "Fusarium head blight in Latin America" presents the current state of knowledge regarding mycological aspects that make wheat-Fusarium interaction, such as hyphal growth, morphogenesis in germinating spores, visualization of enzymatic hydrolysis, production of mycotoxins, inhibition of the hyphal growth by antagonist microorganisms, use of natural substances or by modification of the host resistance, as well as genetic analysis and expression of genes that regulate the infection.

311p lucchinguyen 28-12-2023 6 2   Download

Part 1 book "Animal influenza virus" includes content: Hemagglutination assay for influenza virus; hemagglutination inhibition assay for influenza virus subtype identification and the detection and quantitation of serum antibodies to influenza virus; neuraminidase inhibition assay for the identification of influenza a virus neuraminidase virus subtype or neuraminidase antibody specificity; reverse genetics of influenza virus; immunohistochemical staining of influenza virus in tissues,... and other contents.

241p oursky10 07-12-2023 6 2   Download

Part 2 book "Fundamentals of biochemistry, life at the molecular level" includes content: Enzyme kinetics, inhibition, and control biochemical signaling; nucleotides, nucleic acids, and genetic information; amino acids, membrane transport; lipids and biological membranes; enzymatic catalysis, biochemical signaling, glucose catabolism,... and other contents.

441p oursky05 20-09-2023 5 3   Download

Continued part 1, part 2 of ebook "Animal biotechnology 2: Emerging breeding technologies" presents the following content: regulatory dysfunction inhibits the development and application of transgenic livestock for use in agriculture; genetically engineered large animals in biomedicine; stem cells and cell conversion in livestock; the legal governance of animal biotechnologies; ethical aspects of animal biotechnology; public perception of animal biotechnology;...

152p dieptieuung 14-07-2023 7 1   Download

Osteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known functional polymorphisms in the TGF-β inhibiting genes, asporin (ASPN) and cartilage intermediate layer protein (CILP), with hand OA and potential gene-occupational hand loading interaction.

8p vinarcissa 21-03-2023 1 1   Download

Acid soil is a serious limitation to crop production all over the world. Toxic aluminium (Al) cations in acid soil inhibit root growth and reduce yield. Although a gene tolerant to acid soil has been identified, it has not been used in malting barley breeding, which is partly due to the acid soil tolerance gene being linked to unfavorable malting quality traits.

11p vinarcissa 21-03-2023 4 1   Download

As part of a research aiming at the isolation of bacteria secreting growth-inhibiting compounds, cultures of Francisella tularensis were implanted in environmental samples and monitored for inhibition zones on agar.

4p vihagrid 30-01-2023 13 3   Download

Several studies have demonstrated the antitumor activity of rosiglitazone (RGZ) in cancer cells, including breast cancer cells. However, the molecular targets of RGZ in the inhibition of angiogenesis in breast cancer cells remain unclear.

17p vihagrid 30-01-2023 7 3   Download

Retrotransposons play a central role in plant evolution and could be a powerful endogenous source of genetic and epigenetic variability for crop breeding. To ensure genome integrity several silencing mechanisms have evolved to repress retrotransposon mobility.

10p vialfrednobel 29-01-2022 12 0   Download

CRISPR-Cas9 has been developed as a therapeutic agent for various infectious and genetic diseases. In many clinically relevant applications, constitutively active CRISPR-Cas9 is delivered into human cells without a temporal control system. Excessive and prolonged expression of CRISPR-Cas9 can lead to elevated off-target cleavage.

15p viarchimedes 26-01-2022 7 0   Download

Quantitative structure–activity relationship (QSAR) analysis of 28 quinoline-arylamidine (CQArA) hybrids against two leukemia cells, K562 and Raji, was performed. Multiple linear regression (MLR) models were obtained by genetic algorithm. The best models involved the following descriptors: radial distribution function (RDF) descriptors, GETAWAY (GEometry, Topology, and Atom-Weights AssemblY) descriptor, bond information content index, and dipole moment. The best MLR models for K562 and Raji cells demonstrated satisfactory stability in internal and external validation.

16p tudichquannguyet 29-11-2021 7 1   Download

Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor suppressor genes. Tea polyphenols may inhibit DNMT activity.

12p vimahuateng 26-11-2021 3 0   Download

The past years have seen the rise of genomic biobanks and mega-scale meta-analysis of genomic data, which promises to reveal the genetic underpinnings of health and disease. However, the over-representation of Europeans in genomic studies not only limits the global understanding of disease risk but also inhibits viable research into the genomic differences between carriers and patients.

19p vilichoo2711 23-06-2021 9 1   Download

C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data regarding Clec14a role in promoting or inhibiting angiogenesis, therefore its functional role in vascular development remains poorly understood.

10p viwyoming2711 16-12-2020 9 2   Download

Endostatin (ES) inhibits endothelial cell proliferation, migration, invasion, and tube formation. It also shows antiangiogenesis and antitumor activities in several animal models. Endostatin specifically targets tumor vasculature to block tumor growth.

12p vijennie2711 29-09-2020 10 2   Download

PA-MSHA, a genetically engineered Pseudomonas aeruginosa (PA) strain, is currently under investigation as a new anti-cancer drug. It can induce cell cycle arrest and apoptosis in different human cancer cells, including hormone receptor negative breast cancer cells.

9p virose2711 24-09-2020 12 0   Download

Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations often have altered cell cycles that offer proliferative advantages and lead to the accumulation of additional mutations that can lead to more aggressive phenotypes.

11p virose2711 22-09-2020 11 3   Download

Pancreatic cancer is one of the deadliest human malignancies, with few therapeutic options. Re-activation of embryonic signaling pathways is commonly in human pancreatic cancer and provided rationale to explore inhibition of these pathways therapeutically.

11p vilisa271 22-09-2020 10 1   Download