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Genetic integrity
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Part 1 book "Quantitative genetics, genomics and plant breeding" includes content: Quantitative genetics, genomics and the future of plant breeding; why quantitative geneticists should care about bioinformatics; QTL analysis - problems and (possible) solutions; association mapping in plant populations; integrating molecular techniques into quantitative genetics and plant breeding; use of molecular markers in plant breeding - drought tolerance improvement in tropical maize, explorations with barley genome maps;... and other contents.
235p
dianmotminh04
12-07-2024
0
0
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Chemoradiotherapy is a critical treatment for patients with locally advanced and unresectable nonsmall cell lung cancer (NSCLC), and it is essential to identify high-risk patients as early as possible owing to the high incidence of radiation pneumonitis (RP). This study aimed to investigate the value of computed tomography (CT)-based radiomics combined with genomics in analyzing the risk of grade≥2 RP in unresectable stage III NSCLC.
10p
vishanshan
27-06-2024
1
1
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T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with poor prognosis and inferior outcome. Although multiple studies have been perform on genomics of T-ALL, data from Indian sub-continent is scarce.
9p
vikoch
27-06-2024
2
1
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Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity.
774p
vimeyers
29-05-2024
2
2
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Ebook "Genome mapping and genomics in arthropods" provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. Insects and other arthropods, the largest group of animals in number of species, have global impact on agriculture, industry, human health and environment. They are of particular economic importance for food production as pollinators, for natural products like silk and also as pests and parasites.
133p
dongmelo
27-05-2024
8
3
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Ebook "Tomato yellow leaf curl virus disease: Management, molecular biology, breeding for resistance" will awaken the interest of breeders, phytopathologists, environmentalists, extension services, plant virologists, entomologists and molecular biologists. It deals both with the epidemiological aspects of the disease and with integrated pest management in the field. It discusses the efforts aimed at breeding tomato plants resistant to the virus (using classical breeding, marker-assisted breeding and genetic engineering).
437p
ladongphongthanh1008
22-04-2024
2
2
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Ebook "Evolutionary transitions to multicellular life: Principles and mechanisms" integrates our understanding of the factors and processes underlying the evolution of multicellularity by providing several complementary perspectives (both theoretical and experimental) and using examples from various lineages in which multicellularity evolved.
489p
ladongphongthanh1008
22-04-2024
5
2
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Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers.
11p
vibransone
28-03-2024
5
2
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Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.
22p
vibransone
28-03-2024
3
2
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Hepatocellular carcinoma (HCC) is the one of the most common cancers and lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and may play important roles in carcinogenesis and diagnosis.
11p
vibransone
28-03-2024
5
2
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Although large-scale, next-generation sequencing (NGS) studies of cancers hold promise for enabling precision oncology, challenges remain in integrating NGS with clinically validated biomarkers. To overcome such challenges, we utilized the Database of Evidence for Precision Oncology (DEPO) to link druggability to genomic, transcriptomic, and proteomic biomarkers.
20p
vibransone
28-03-2024
3
2
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Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.
15p
vibransone
28-03-2024
4
2
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The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from a genetic variant to a complex trait.
15p
vibransone
28-03-2024
4
2
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Genome-wide association studies (GWAS) have identified several hundred susceptibility loci for type 2 diabetes (T2D). One critical, but unresolved, issue concerns the extent to which the mechanisms through which these diverse signals influencing T2D predisposition converge on a limited set of biological processes.
14p
vibransone
28-03-2024
3
1
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The present research and model is aimed at presenting an integrated multi-objective optimal supply chain model of Sepah Bank's green supply chain in terms of model uncertainty using meta-heuristic algorithms and providing a suitable conceptual framework. In this regard, a multiobjective optimization model is presented and solved using fireworks algorithms based on Pareto Archive and NSGA-II. The green banking phenomenon has emerged with the same purpose in the banking system of the world and today it has made significant progress in theoretical and operational aspects.
11p
longtimenosee07
29-03-2024
2
2
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Tissue-specific integrative omics has the potential to reveal new genic elements important for developmental disorders. Methods: Two pediatric patients with global developmental delay and intellectual disability phenotype underwent array-CGH genetic testing, both showing a partial deletion of the DLG2 gene. From independent human and murine omics datasets, we combined copy number variations, histone modifications, developmental tissue-specific regulation, and protein data to explore the molecular mechanism at play.
20p
vioraclene
31-03-2024
4
2
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Biomedical research is becoming increasingly large-scale and international. Cloud computing enables the comprehensive integration of genomic and clinical data, and the global sharing and collaborative processing of these data within a flexibly scalable infrastructure.
12p
vioraclene
31-03-2024
4
2
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Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with complex traits and diseases. However, elucidating the causal genes underlying GWAS hits remains challenging.
6p
vioraclene
31-03-2024
4
2
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The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations.
15p
vioraclene
31-03-2024
4
2
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Precision medicine (PM) can be defined as a predictive, preventive, personalized, and participatory healthcare service delivery model. Recent developments in molecular biology and information technology make PM a reality today through the use of massive amounts of genetic, ‘omics’, clinical, environmental, and lifestyle data.
12p
vioraclene
31-03-2024
3
2
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