![](images/graphics/blank.gif)
Genetic variability analysis
-
Chlamydia trachomatis (Ct) is the most common infectious cause of blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to the observed variability in severity of clinical disease.
19p
vibransone
28-03-2024
3
2
Download
-
The human plasma proteome is important for many biological processes and targets for diagnostics and therapy. It is therefore of great interest to understand the interplay of genetic and environmental factors to determine the specific protein levels in individuals and to gain a deeper insight of the importance of genetic architecture related to the individual variability of plasma levels of proteins during adult life.
16p
vibransone
28-03-2024
5
2
Download
-
Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.
15p
vioraclene
31-03-2024
4
1
Download
-
Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses
The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare variants relative to common variants in immune response variability in healthy individuals remains unclear.
17p
vibransone
28-03-2024
2
2
Download
-
Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p
viellison
28-03-2024
3
2
Download
-
In ebook "Weighted network analysis: Applications in genomics and systems biology" high-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.
433p
cotieubac1004
15-03-2024
6
0
Download
-
Core collections are important tools in genetic resources research and administration. At present, most core collection selection criteria are based on one of the following item characteristics: passport data, genetic markers, or morphological traits, which may lead to inadequate representations of variability in the complete collection.
10p
vinarcissa
21-03-2023
2
1
Download
-
Structural equation modeling (SEM) is an extremely general and powerful approach to account for measurement error and causal pathways when analyzing data, and it has been used in wide range of applied sciences. There are many commercial and freely available software packages for SEM. However, it is difficult to use any of the packages to analyze general pedigree data, and SEM packages for genetics are limited in their application.
13p
vinarcissa
21-03-2023
4
1
Download
-
Genome-wide Association Studies (GWAS) are typically designed to identify phenotype-associated single nucleotide polymorphisms (SNPs) individually using univariate analysis methods. Though providing valuable insights into genetic risks of common diseases, the genetic variants identified by GWAS generally account for only a small proportion of the total heritability for complex diseases.
11p
vinarcissa
21-03-2023
3
1
Download
-
Mitochondrial cytopathies are characterized by a large variability of clinical phenotypes and severity. The amount of mutant mitochondrial DNA (mtDNA) in a cell, called the heteroplasmy level, is an important determinant of the degree of mitochondrial dysfunction and therefore disease severity.
8p
vinarcissa
21-03-2023
2
1
Download
-
Hypertension is a complex trait that often co-occurs with other conditions such as obesity and is affected by genetic and environmental factors. Aggregate indices such as principal components among these variables and their responses to environmental interventions may represent novel information that is potentially useful for genetic studies.
10p
vinarcissa
21-03-2023
6
1
Download
-
Multiple hypothesis testing is a pervasive problem in genomic data analysis. The conventional Bonferroni method which controls the family-wise error rate is conservative and with low power. The current paradigm is to control the false discovery rate.
4p
vinarcissa
21-03-2023
3
1
Download
-
Climate change is expected to have a negative impact on food availability. While most efforts have been directed to reducing greenhouse gas emissions, complementary strategies are necessary to control the detrimental effects of climate change on farm animal performance.
10p
vihagrid
30-01-2023
5
3
Download
-
(BQ) Ebook Methods in human growth research: Part 2 presents the following content: Parametric models for postnatal growth; parameter estimation in the context of non-linear longitudinal growth models; univariate and bivariate growth references; latent variables and structural equation models; multilevel modeling; methods for the study of the genetics of growth and development; prediction; ordinal longitudinal data analysis.
195p
runordie7
30-08-2022
7
2
Download
-
Free-range local chickens (FRLC) farming is an important activity in Tanzania, however, they have not been well-characterized. This study aimed to phenotypically characterize three Tanzanian FRLCs and to determine their population structure. A total of 389 mature breeder chickens (324 females and 65 males) from three popular Tanzanian FRLC ecotypes (Kuchi, Morogoro-medium and Ching’wekwe) were used for the phenotypic characterization.
10p
vigandhi
23-02-2022
8
1
Download
-
We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQTL annotations to delineate and tackle the unique challenges arising in TWAS.
26p
viarchimedes
26-01-2022
13
0
Download
-
Ecologists use various data mining techniques to make predictions and estimations, to identify patterns in datasets and relationships between qualitative and quantitative variables, or to classify variables. The aim of this study was to investigate if the application of data mining could be used to study geographical variation in the morphometry, craniometry, and diet of a mammalian species (Martes foina), and to determine whether data mining can complement genetic analysis to recognize subspecies.
8p
dolomite36
30-12-2021
9
0
Download
-
Drought is a major threat to wheat production worldwide and development of drought-tolerant wheat genotypes may improve the production of this cereal crop in drought affected regions. In the present study, 24 mutant lines were developed by treating a wheat variety ‘NN-Gandum-1(NN-1) with ethyl methane sulfonate (EMS). The M5 , M6 , and M7 generations were evaluated for quantitative traits under well irrigated and rainfed conditions. Furthermore, best performing mutants of M6 and M7 generations were examined for biochemical parameters.
17p
hanthienngao
30-11-2021
16
1
Download
-
Household contacts of cholera patients have a 100 times higher risk of developing a cholera infection than the general population. To compare the genetic relatedness of clinical and water source Vibrio cholerae isolates from cholera patients’ households across three outbreaks, we analyzed these isolates using whole-genome-sequencing (WGS) and multilocus variable-number tandem-repeat analysis (MLVA).
10p
vilarryellison
29-10-2021
9
0
Download
-
Runs of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection due to technological advances in the late 1990s, ROHs have been shedding light on human population history and deciphering the genetic basis of monogenic and complex traits and diseases. ROH studies have predominantly exploited SNP array data, but are gradually moving to whole genome sequence (WGS) data as it becomes available. WGS data, covering more genetic variability, can add value to ROH studies, but require additional considerations during analysis
12p
vibeauty
23-10-2021
9
0
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)