Genome-wide Association Study

The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of diseaseassociated genes in genome-wide association studies (GWASs).

19p vielonmusk 30-01-2022 6 0   Download

Genome-wide association studies (GWAS) search for marker variants indirectly associated with certain diseases and/or traits. They assume that markers are in linkage disequilibrium (LD) with underlying causal variants.

3p vialfrednobel 29-01-2022 7 0   Download

The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies. However, acute depletion of CTCF globally reduces chromatin interactions but does not significantly alter transcription.

25p viarchimedes 26-01-2022 3 0   Download

Structural variations (SVs), a major resource of genomic variation, can have profound consequences on phenotypic variation, yet the impacts of SVs remain largely unexplored in crops.

25p viarchimedes 26-01-2022 0 0   Download

Osteoporosis is a complex disease with a strong genetic contribution. A recently published genomewide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genomewide significant association signals. Most of these variants are non-coding, suggesting that regulatory effects may drive many of the associations.

13p viarchimedes 26-01-2022 4 0   Download

Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association study (GWAS) of 85 face morphological traits in 7569 Koreans (5643 in the discovery set and 1926 in the replication set).

17p vibeauty 23-10-2021 2 0   Download

Beak deformity, typically expressed as the crossing of upper and lower mandibles, is found in several indigenous chicken breeds, including the Beijing-You chickens studied here. Beak deformity severely impairs the birds’ growth and welfare. Although previous studies shed some light on the genetic regulation of this complex trait, the genetic basis of this malformation remains incompletely understood.

10p vibeauty 23-10-2021 3 0   Download

The understanding of the biological determinism of meat ultimate pH, which is strongly related to muscle glycogen content, is a key point for the control of muscle integrity and meat quality in poultry. In the present study, we took advantage of a unique model of two broiler lines divergently selected for the ultimate pH of the pectoralis major muscle (PM-pHu) in order to decipher the genetic control of this trait.

14p vibeauty 23-10-2021 2 0   Download

There exist few, if any, practical guidelines for predictive and falsifiable multi-omic data integration that systematically integrate existing knowledge. Disease modules are popular concepts for interpreting genomewide studies in medicine but have so far not been systematically evaluated and may lead to corroborating multiomic modules.

13p vitzuyu2711 29-09-2021 6 0   Download

Salinity is an abiotic stress that negatively affects soybean [Glycine max (L.) Merr.] seed yield. Although a major gene for salt tolerance was identified and consistently mapped to chromosome (Chr.) 3 by linkage mapping studies, it does not fully explain genetic variability for tolerance in soybean germplasm.

16p visilicon2711 20-08-2021 1 0   Download

Common bunt (caused by Tilletia caries and T. foetida) has been considered as a major disease in wheat (Triticum aestivum) following rust (Puccinia spp.) in the Near East and is economically important in the Great Plains, USA.

14p vishikamaru2711 29-04-2020 8 0   Download