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Genome-wide sequencing
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Very low-coverage (0.1 to 1×) whole genome sequencing (WGS) has become a promising and aford‑ able approach to discover genomic variants of human populations for genome-wide association study (GWAS).
18p
vicwell
29-02-2024
2
1
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Genome-wide association studies (GWAS) search for marker variants indirectly associated with certain diseases and/or traits. They assume that markers are in linkage disequilibrium (LD) with underlying causal variants.
3p
vialfrednobel
29-01-2022
15
0
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The development of sequencing technologies has promoted the survey of genomewide chromatin accessibility at single-cell resolution. However, comprehensive analysis of single-cell epigenomic profiles remains a challenge.
27p
viarchimedes
26-01-2022
10
0
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Simple sequence repeats (SSRs) are tandem repeats of DNA that have been used to develop robust genetic markers. These molecular markers are powerful tools for basic and applied studies such as molecular breeding. In the model plants in Nicotiana genus e.g. N. benthamiana, a comprehensive assessment of SSR content has become possible now because several Nicotiana genomes have been sequenced. We conducted a genomewide SSR characterization and marker development across seven Nicotiana genomes.
12p
vibeauty
23-10-2021
8
1
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Glyphosate has become the most widely used herbicide in the world. Therefore, the development of new varieties of glyphosate-tolerant crops is a research focus of seed companies and researchers.
15p
vijeeni2711
24-07-2021
11
0
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The preferred choice for molecular marker development is identifying existing variation in populations through DNA sequencing. With the genome resources currently available for bitter gourd (Momordica charantia), it is now possible to detect genome-wide insertion-deletion (InDel) polymorphisms among bitter gourd populations, which guides the efficient development of InDel markers.
9p
vilichoo2711
23-06-2021
10
1
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RNA sequencing (RNA-seq) is a high throughput technology that profiles gene expression in a genomewide manner. RNA-seq has been mainly used for testing differential expression (DE) of transcripts between two conditions and has recently been used for testing differential alternative polyadenylation (APA).
9p
viflorida2711
30-10-2020
15
1
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Although ultrahigh-throughput RNA-Sequencing has become the dominant technology for genomewide transcriptional profiling, the vast majority of RNA-Seq studies typically profile only tens of samples, and most analytical pipelines are optimized for these smaller studies.
10p
viflorida2711
30-10-2020
12
2
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