Genomic conflict

Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. Such effects, however, could lead to conflicts among studies, while further impacting study outcomes and efforts to translate research findings.

21p vioraclene 31-03-2024 6 1   Download

Breast cancer is the most common cause of cancer death among women. Several studies have investigated the relationship between the C3435T polymorphism of ABCB1 gene and risk of breast cancer; but the results are conflicting. In the present study, we sought to assess the relationship between the C3435T polymorphism in ABCB1 gene and the risk of breast cancer in a sample of the Moroccan population.

11p vinarcissa 21-03-2023 2 1   Download

Crossover localization during meiotic recombination is mediated by the fast-evolving zinc-finger (ZnF) domain of gene PRDM9. To study its impact on dairy cattle performance, we compared its genetic variation between the relatively small Israeli (IL) Holsteins and the North American (US) Holsteins that count millions.

11p vihagrid 30-01-2023 10 3   Download

(BQ) Ebook Brain, behavior and epigenetics: Part 2 presents the following content: Chapter 8: The Strategies of the Genes: Genomic Conflicts, Attachment Theory, and Development of the Social Brain; Chapter 9: Genomic Imprinting Effects on Brain and Behavior: Future Directions; Chapter 10: Epigenetic Influence of the Social Environment; Chapter 11: Toward an Understanding of the Dynamic Interdependence of Genes and Environment in the Regulation of Phenotype; Chapter 12: Histone Deacetylase Inhibitors: A Novel Therapeutic Approach for Cognitive Disorders; Chapter 13: Epigenetic Mechanisms of ...

175p runordie7 30-08-2022 7 2   Download

The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome.

4p vialfrednobel 29-01-2022 12 0   Download

Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomally integrated HHV-6 (iciHHV-6). Only two complete genomes are available for replicating HHV-6B, leading to numerous conflicting annotations and little known about the global genomic diversity of this ubiquitous virus.

17p vibeauty 23-10-2021 5 1   Download

The current literature on single cell genomic analyses on the DNA level is conflicting regarding requirements for cell quality, amplification success rates, allelic dropouts and resolution, lacking a systematic comparison of multiple cell input down to the single cell.

9p vitzuyu2711 29-09-2021 5 1   Download

To date, evidence for the relative prevalence or rarity of molecular convergent and parallel evolution is conflicting, and understanding of how these processes contribute to adaptation is limited.

14p vijeeni2711 30-06-2021 10 1   Download

Malnutrition in Somalia is a huge public health problem, negatively affecting growth, development and survival of the population. Situational analysis shows a long term nutrition crisis characterised by persistently high rates of acute and chronic malnutrition throughout the country with some variation by zone and livelihood system. This situation reflects nearly two decades of armed conflict and insecurity, with breakdown in social and public services coupled with recurrent droughts and flooding seriously affecting food security and livelihoods.

61p nhamnhiqa 01-03-2013 43 2   Download

Institutions and individuals involved in human subjects research may establish financial relationships related to or separate from particular research projects. Those financial relationships may create financial interests of monetary value, such as payments for services, equity interests, or intellectual property rights. A financial interest related to a research study may be a conflicting financial interest. The Department recognizes that some conflicting financial interests in research may affect the rights and welfare of human subjects.

17p doipassword 01-02-2013 51 4   Download

Physical water resource constraints make companies more susceptible to reputational risks. Declines in water availability and quality can increase competition for clean water. In water-scarce regions, tensions can arise between businesses and local communities, particularly in developing countries where local populations often lack access to safe and reliable drinking water. Community opposition to industrial water withdrawals and perceived or real inequities in use can emerge quickly and affect businesses profoundly.

34p saimatkhauroi 01-02-2013 59 3   Download

Progress towards gender equality is a critical issue for us. …..First we will adopt measures to restore those rights to our women and girls that they were denied because of the segregationist policies of the Taliban and the threat to their personal security during periods of conflict. To support this, we will need to create women's specific opportunities that will allow them to catch up with men and boys.

76p le_minh_nha 18-12-2012 46 1   Download