Genomic range

Ebook "Mycobacteria protocols (Second edition)" updates and refines the methods of the well-received first edition while adding newly developed methods culled from the most cutting-edge research in the field. Ranging from the basics of sub-cellular fractionation to advanced methods using specialized growth conditions and whole genome, transcriptome and proteome analysis, the chapters conform to the Methods in Molecular Biology™ series format, providing step-by-step laboratory protocols, lists of necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls.

485p dongmelo 27-05-2024 8 3   Download

The 2014–2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host factors/pathways essential for the virus are advantageous because they can potentially target a wide range of viruses, including newly emerging ones and because the development of resistance is less likely than when targeting the virus directly.

14p vibransone 28-03-2024 2 2   Download

The phenotypic severity of congenital muscular dystrophy-dystroglycanopathy (MDDG) syndromes associated with aberrant glycosylation of α-dystroglycan ranges from the severe Walker-Warburg syndrome or muscle-eye-brain disease to mild, late-onset, isolated limb-girdle muscular dystrophy without neural involvement.

11p vioraclene 31-03-2024 3 2   Download

Klebsiella pneumoniae is a gram-negative bacterial species capable of occupying a broad range of environmental and clinical habitats. Known as an opportunistic pathogen, it has recently become a major causative agent of clinical infections worldwide.

10p vioraclene 31-03-2024 6 2   Download

Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both initial and stable dosing with warfarin.

12p vioraclene 31-03-2024 9 2   Download

Enabled by high-throughput sequencing approaches, epithelial cancers across a range of tissue types are seen to harbor gene fusions as integral to their landscape of somatic aberrations. Although many gene fusions are found at high frequency in several rare solid cancers, apart from fusions involving the ETS family of transcription factors which have been seen in approximately 50 % of prostate cancers, several other common solid cancers have been shown to harbor recurrent gene fusions at low frequencies.

18p vioraclene 31-03-2024 3 0   Download

The majority of clinical genetic testing focuses almost exclusively on regions of the genome that directly encode proteins. The important role of variants in non-coding regions in penetrant disease is, however, increasingly being demonstrated, and the use of whole genome sequencing in clinical diagnostic settings is rising across a large range of genetic disorders.

19p viellison 28-03-2024 4 2   Download

We describe a case series of five infants (age range: 1–90 days; 4 females and 1 male) who presented to Al Jalila Children’s intensive care units (ICU) with complex multisystem disorders. Patients were Emirati, Kenyan, Jordanian, Filipino, or Pakistani.

5p viellison 28-03-2024 2 1   Download

Ebook "Biosynthesis and molecular genetics of fungal secondary metabolites (Volume 2)" covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

263p cotieubac1004 15-03-2024 1 0   Download

To diagnose the full spectrum of hereditary and congenital diseases, genetic laboratories use many different workfows, ranging from karyotyping to exome sequencing. A single generic high-throughput workflow would greatly increase efciency. We assessed whether genome sequencing (GS) can replace these existing workflows aimed at germline genetic diagnosis for rare disease.

11p vicwell 29-02-2024 4 2   Download

Changes in cell-type composition of tissues are associated with a wide range of diseases and environmental risk factors and may be causally implicated in disease development and progression. However, these shifts in cell-type fractions are often of a low magnitude, or involve similar cell subtypes, making their reliable identification challenging.

24p vicwell 29-02-2024 3 1   Download

Ebook "Site-directed insertion of transgenes" aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification.

393p nhanphanguyet 28-01-2024 3 2   Download

Ebook "Agrobacterium: From biology to biotechnology" continues with a description of how Agrobacterium is used as a tool in plant biotechnology. The next two chapters describe our knowledge of the Agrobacterium genome gained with the advent of genomics approaches and place Agrobacterium in the taxonomic context of related bacterial species. The main portion of the book, which comprises 11 chapters, provides a detailed review of virtually all molecular aspects of the genetic transformation process, including chemistry, biochemistry and molecular biology of host recognition and attachment,...

768p tachieuhoa 28-01-2024 6 2   Download

Ebook "Microbial stress tolerance for biofuels: Systems biology" provides an overview of methods for studying microbial stress tolerance for biofuels applications using a systems biology approach. Topics covered range from mechanisms to methodology for yeast and bacteria, including the genomics of yeast tolerance and detoxification; genetics and regulation of glycogen and trehalose metabolism; programmed cell death; high gravity fermentations;...

311p tachieuhoa 28-01-2024 4 2   Download

Ebook "Biology, physiology and molecular biology of weeds" provides comprehensive information on a wide range of topics from biology, physiology, genetics to the use of genomic tools in weed science. The book covers information at a more advanced level than the previously published books in weed science. It covers not only weed genetics and genomics research, but also weed management from an ecological perspective.

231p lamquandat 28-12-2023 12 3   Download

Ebook "Brachypodium genomics: Methods and protocols" presents protocols for Brachypodium genomics in numerous areas ranging from marker development, trait evolution, functional genomics, metabolomics, transcriptomics, genomics, and tilling. This book also explores techniques to study the widening genetic base of Brachypodium that will help researchers better understand the model plant using NGS technologies.

309p lucchinguyen 28-12-2023 7 2   Download

Ebook "The handbook of culture and biology" provides an overview of current empirical and theoretical advances in culture and biology interplay research through the work of some of the most influential scholars in the field. Harnessing insights from a range of disciplines and research methods (experiments, genetic epidemiology, naturalistic observations, neuroimaging), it explores diverse topics including animal culture, cultural genomics, and neurobiology of cultural experiences. The authors also advance the field by discussing key challenges and limitations in current research.

543p lucchinguyen 28-12-2023 7 3   Download

Ebook "Systems biology of marine ecosystems" describes the latest advances in systems biology in four plant-based marine ecosystems: seaweeds, seagrasses, microalgae, and corals. Marine organisms that inhabit the oceanic environment experience a diverse range of environmental fluctuations, anthropogenic stress, and threats from invasive species and pathogens.

355p lucchinguyen 28-12-2023 4 2   Download

Part 1 book "PCR Protocols" includes content: Long range PCR with a DNA polymerase fusion, isolation of genomic insertion sites of proviruses using splinkerette PCR based procedures, lariat dependent nested PCR for flanking sequence determination, a global single-Cell cDNA amplification method for quantitative microarray analysis,...and other contents.

171p oursky06 17-10-2023 5 1   Download

Anterior cruciate ligament rupture (ACLR) is a debilitating and potentially life-changing condition in humans, as there is a high prevalence of early-onset osteoarthritis after injury. Identification of high-risk individuals before they become patients is important, as post-treatment lifetime burden of ACLR in the USA ranges from $7.6 to $17.7 billion annually. ACLR is a complex disease with multiple risk factors including genetic predisposition.

10p vinarcissa 21-03-2023 4 2   Download