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Genomics platform
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Single-cell RNA sequencing (scRNA-Seq) is an increasingly popular platform to study heterogeneity at the single-cell level. Computational methods to process scRNA-Seq data are not very accessible to bench scientists as they require a significant amount of bioinformatic skills.
12p
vioraclene
31-03-2024
3
2
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Preclinical studies require models that recapitulate the cellular diversity of human tumors and provide insight into the drug sensitivities of specific cellular populations. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity.
15p
vibransone
28-03-2024
3
2
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Identification of clinically significant genetic alterations involved in human disease has been dramatically accelerated by developments in next-generation sequencing technologies. However, the infrastructure and accessible comprehensive curation tools necessary for analyzing an individual patient genome and interpreting genetic variants to inform healthcare management have been lacking.
12p
vibransone
28-03-2024
2
2
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Ebook "Drug discovery in Africa: Impacts of genomics, natural products, traditional medicines, insights into medicinal chemistry, and technology platforms in pursuit of new drugs" has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa.
453p
coduathanh1122
27-03-2024
1
1
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Long-read whole genome sequencing (lrWGS) has the potential to address the technical limitations of exome sequencing in ways not possible by short-read WGS. However, its utility in autosomal recessive Mendelian diseases is largely unknown. Methods In a cohort of 34 families in which the suspected autosomal recessive diseases remained undiagnosed by exome sequencing, lrWGS was performed on the Pacifc Bioscience Sequel IIe platform.
16p
vicwell
29-02-2024
2
2
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Part 1 book "Mouse as a model organism" includes content: Genomic insulators in transgenic animals, the german mouse clinic running an open access platform, nature and nurture - impacts on mouse phenotypes and translational research, the informatics of high throughput mouse phenotyping - Eumodic and beyond.
104p
muasambanhan03
25-12-2023
2
1
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Advancements in human genomics have generated a surge of available data, fueling the growth and accessibility of databases for more comprehensive, in-depth genetic studies. Results are consistent across the 2 cloud providers and could be highly useful for accelerating research in genetics.
6p
vighostrider
25-05-2023
5
2
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Testing gene-gene interaction in genome-wide association studies generally yields lower power than testing marginal association. Meta-analysis that combines different genotyping platforms is one method used to increase power when assessing gene-gene interactions, which requires a test for interaction on untyped SNPs.
9p
vinarcissa
21-03-2023
4
1
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Part 1 of ebook "Plant biology and biotechnology (Volume II: Plant genomics and biotechnology)" provide readers with content about: arabidopsis thaliana - a model for plant research; microalgae in biotechnological application - a commercial approach; application of biotechnology and bioinformatics tools in plant–fungus interactions;... Please refer to the part 1 of ebook for details!
405p
langmongnhu
14-12-2022
15
3
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Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this new way of sequencing and has used it successfully for a variety of research applications.
11p
vigalileogalilei
27-02-2022
10
1
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Current genotyping approaches for single-nucleotide variations rely on short, accurate reads from second-generation sequencing devices. Presently, third-generation sequencing platforms are rapidly becoming more widespread, yet approaches for leveraging their long but error-prone reads for genotyping are lacking.
16p
vigalileogalilei
27-02-2022
9
1
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Basecalling, the computational process of translating raw electrical signal to nucleotide sequence, is of critical importance to the sequencing platforms produced by Oxford Nanopore Technologies (ONT).
10p
vigalileogalilei
27-02-2022
13
1
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Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we present the first report to compare the cheaper BGISEQ-500 platform to the Illumina HiSeq platform for scRNA-seq. We generate a resource of 468 single cells and 1297 matched single cDNA samples, performing SMARTer and Smart-seq2 protocols on two cell lines with RNA spike-ins.
8p
vigalileogalilei
27-02-2022
11
1
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Increasing genetic diversity via directed evolution holds great promise to accelerate trait development and crop improvement. We developed a CRISPR/Cas-based directed evolution platform in plants to evolve the rice (Oryza sativa) SF3B1 spliceosomal protein for resistance to splicing inhibitors.
9p
vigalileogalilei
27-02-2022
5
1
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We propose a statistical boosting method, termed I-Boost, to integrate multiple types of high-dimensional genomics data with clinical data for predicting survival time. I-Boost provides substantially higher prediction accuracy than existing methods.
15p
vigalileogalilei
27-02-2022
12
2
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Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and growth rate upstream of highly multiplexed single-cell profiling such as single-cell RNA sequencing.
13p
vigalileogalilei
27-02-2022
21
2
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The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can induce significant levels of unintended mutations at near-cognate sites, necessitating substantial efforts toward the development of strategies to minimize off-target activity.
25p
vigalileogalilei
27-02-2022
15
1
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Akabane virus (AKAV) is an important insect-borne virus which is widely distributed throughout the world except the Europe and is considered as a great threat to herbivore health. We successfully isolated a AKAV strain TJ2016 from the sera of cattle and established a reverse genetic platform for AKAV genome manipulation.
9p
vidarwin
22-02-2022
15
1
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Chromatin provides a tunable platform for gene expression control. Besides the well-studied core nucleosome, H1 linker histones are abundant chromatin components with intrinsic potential to influence chromatin function.
22p
vielonmusk
30-01-2022
15
0
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Several genome-scale metabolic reconstruction software platforms have been developed and are being continuously updated. These tools have been widely applied to reconstruct metabolic models for hundreds of microorganisms ranging from important human pathogens to species of industrial relevance.
20p
vielonmusk
30-01-2022
9
0
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