Glucocorticoids pharmacologically
-
Ebook "Progress in the chemistry of organic natural products: Volume 94" review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.
269p manmanthanhla0201 26-02-2024 2 1 Download
-
Glucocorticoid has been used extensively in clinical applications, because of its several pharmacologic actions, which include immunosuppression, anti-inflammation, anti-shock, and relief of asthma.
7p viannito2711 20-04-2021 7 2 Download
-
11ß–hydroxysteroid dehydrogenase type1 (11β-HSD1) converts inactive glucocorticoids to active glucocorticoids which, in excess, leads to development of the various risk factors of the metabolic syndrome.
15p vienzym2711 03-04-2020 12 2 Download
-
Glucocorticoids affect peripheral immune responses, including modulation of T-cell activation, differentiation, and apoptosis. The quantity and quality of T-cell receptor (TCR)-triggered intracellular signals modulate T-cell function. Thus, glucocorticoids may affect T cells by interfering with the TCR signaling cascade.
12p vienzym2711 03-04-2020 12 2 Download
-
It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell function, their roles in Leydig cell development are unclear.
10p vimax2711 27-03-2020 10 1 Download
-
Due to broad range of effects, corticosteroids are frequently used in veterinary practice. Wide ranges of biological effects are mediated via different dose and potency of different glucocorticoids. Intensive short-term glucocorticoid use can decrease the morbidity and mortality of potentially fatal conditions but in long run their use can lead to immunosuppression, duodenal ulceration, pancreatitis, adrenal atrophy, hyperadrenocorticism, glucose intolerance and many more diseases.
7p cothumenhmong3 22-02-2020 13 1 Download
-
Staphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding sequelae.
7p kequaidan1 16-11-2019 22 0 Download
-
This chapter provides a brief overview of the immune response as background for understanding the mechanism of action of immunomodulatory agents. The general principles of pharmacological immunosuppression are discussed in the context of potential targets, major indications, and unwanted side effects.
26p vanass 01-04-2011 67 8 Download
-
Adrenocortical steroids and their synthetic analogues Mechanisms of action Actions: mineralocorticoid, glucocorticoid Individual adrenal steroids Pharmacokinetics Dosage schedules Choice of adrenal steroid Adverse effects of systemic pharmacotherapy Adrenal steroids and pregnancy Precautions during chronic therapy: treatment of intercurrent illness Dosage and routes of administration Indications for use Uses: replacement therapy, pharmacotherapy Withdrawal of pharmacotherapy . Inhibition of synthesis of adrenal steroids. Competitive antagonism .
17p bigbaby87 03-09-2010 77 11 Download