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Glucose stimulated insulin secretion
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Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-gorelated gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia.
9p
vinarcissa
21-03-2023
3
1
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The potassium inwardly rectifying channel, sub-family J, member 11 (KCNJ11), which is a pore-forming sub-unit of ATP sensitive potassium channels in pancreatic B-cells, plays a critical role in the regulation of insulin secretion. A non-synonymous E23K variant (SNP rs5219) in the KCNJ11 gene, which results from C to T transition and substitutes glutamate for lysine at position 23, is identified as a SNP associated with prediabetes and type 2 diabetes.
8p
tamynhan9
02-12-2020
14
2
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Coriander is an annual seed spice crop, which belongs to family Apiaceae. It is native of Mediterranean region. The aromatic characters of plants are due to presence of linalool compound in essential oil of seeds. The green leaves of coriander are used in salads and are a good source of vitamin A and vitamin C. Major active constituents of coriander essential oils and fatty oil. The essential oil content of the weight of ripe and a dried fruit of coriander varies between 0.03 and 2.6% and the content of fatty oil varies between 9.9 and 27.7%.
7p
angicungduoc6
20-07-2020
9
1
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GPR40 is a G-protein coupled receptor regulating free fatty acid induced and also glucose induced insulin secretion. We generated neonatally-streptozotocin-treated female rats (n-STZ) and treated them with CNX-011-67, a GPR40 agonist to examine the role of GPR40 in modulation of glucose metabolism, insulin secretion and content.
15p
vienzym2711
03-04-2020
9
1
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Diabetes mellitus is a chronic disease in which the pancreas no longer produces enough insulin. Pancreatic alpha cell mass increases in response to insufficient insulin secretion. However, the reason for this increase is not clear.
7p
vinasaki2711
12-11-2019
10
0
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The incretin hormones GLP-1 and GIP are released from the gut during meals, and serve as enhancers of glucose stimulated insu-lin release from the beta cells. Furthermore, GLP-1 also stimu-lates beta cell growth and insulin biosynthesis, inhibits glucagon secretion, reduces free fatty acids and delays gastric emptying. GLP-1 has therefore been suggested as a potentially new treat-ment for type 2 diabetes.
46p
fptmusic
11-04-2013
35
2
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Prohibitin (PHB-1) is a highly conserved protein involved in mitochondrial biogenesis and function. It is secreted in lipid droplets from adipocytes and is present in the circulation. In adipose tissue it functions as a membrane receptor and can target binding partners to the mitochondria.
9p
dell39
27-03-2013
38
3
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The ATP-sensitive potassium (KATP) channel couples glucose metabolism to insulin secretion in pancreatic b-cells. It comprises regulatory sulfonyl-urea receptor 1 and pore-forming Kir6.2 subunits. Binding and⁄or hydro-lysis of Mg-nucleotides at the nucleotide-binding domains of sulfonylurea receptor 1 stimulates channel opening and leads to membrane hyperpolari-zation and inhibition of insulin secretion.
13p
galaxyss3
19-03-2013
41
2
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MicroRNA mir-9 is speculated to be involved in insulin secretion because of its ability to regulate exocytosis. Sirt1 is an NAD-dependent protein deacetylase and a critical factor in the modulation of cellular responses to altered metabolic flux. It has also been shown recently to control insulin secretion from pancreaticb-islets.
8p
cosis54
05-01-2013
41
3
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