Glycosylation and glycoproteins

Arabinogalactan-proteins (AGPs) are a class of hydroxyproline-rich proteins (HRGPs) that are heavily glycosylated (> 90%) with type II arabinogalactans (AGs). AGPs are implicated in various plant growth and development processes including cell expansion, somatic embryogenesis, root and stem growth, salt tolerance, hormone signaling, male and female gametophyte development, and defense.

16p vijichea2711 28-05-2021 9 0   Download

Glycoproteins are involved in a diverse range of biochemical and biological processes. Changes in protein glycosylation are believed to occur in many diseases, particularly during cancer initiation and progression. The identification of biomarkers for human disease states is becoming increasingly important, as early detection is key to improving survival and recovery rates.

25p viwyoming2711 16-12-2020 9 1   Download

In addition to causing the pandemic influenza outbreaks of 1918 and 2009, subtype H1N1 influenza A viruses (IAVs) have caused seasonal epidemics since 1977. Antigenic property of influenza viruses are determined by both protein sequence and N-linked glycosylation of influenza glycoproteins, especially hemagglutinin (HA).

22p vicolorado2711 22-10-2020 10 1   Download

(BQ) This part presents an introduction to basic data about the peculiarity of simple and complex carbohydrates and glycoconjugates. Consideration of the unique structure, biosynthesis, degradation and function of glycans forms a basis for consideration of critical changes in many of these processes in disease, and lays the ground work for the chapters that follow.

159p nanhankhuoctai5 01-06-2020 5 0   Download

Hydroxyproline-rich glycoproteins (HRGPs) constitute a plant cell wall protein superfamily that functions in diverse aspects of growth and development. This superfamily contains three members: the highly glycosylated arabinogalactan-proteins (AGPs), the moderately glycosylated extensins (EXTs), and the lightly glycosylated proline-rich proteins (PRPs).

34p vihashirama2711 21-05-2020 8 0   Download

Glycosylation patterns of serum proteins, such as α1-acid glycoprotein, are modified during an acute phase reaction. The response of acute Kawasaki disease (KD) patients to IVIG treatment has been linked to sialic acid levels on native IgG, suggesting that protein glycosylation patterns vary during the immune response in acute KD.

11p videshiki2711 21-02-2020 36 1   Download

Cell recognition molecule L1 (L1) plays an important role in cancer cell differentiation, proliferation, migration and survival, but its mechanism remains unclear.

8p vicaracas2711 27-11-2019 9 1   Download

Glycan parts of glycoconjugates on the surfaces of cells regulate many kinds of interactions between the cells and their immediate environments. Alterations in glycosylation on the cancer-associated glycoproteins are responsible for changes in their molecular interactions and biological functions.

18p vikimsa 22-02-2019 15 1   Download

The traditional RSS production process begins with filtering the fresh latex to rid it of any foreign particles. In the filtered latex some water and acid, typically formic or acetic, is added. The mixture is left standing in moulds for up to 24 hours to allow coagulation, depending on the amount of acid added. The coagulated latex is then pressed into sheets of approximately 0,5 cm of thickness by means of hand or machine powered rollers or even manually using a dough roller or similar device. The final roller has a ribbed pattern, which imprints into the sheet to...

24p thieubaotrang 23-04-2013 47 2   Download

An additional element in the prevention of introduction and spread of disease is the use of vaccination. The manual does not cover this aspect but the importance of an appropriate vaccination strategy is acknowledged, and vaccination as a possible risk management measure should form part of the overall biosecurity assessment and strategy. The purpose of the manual is to establish a minimum set of biosecurity guidelines, applicable to all poultry producers (including ratites) from hatcheries to the point of delivery at the processor.

99p loginnhanh 22-04-2013 95 4   Download

The calculation of indirect and induced (multiplier) impacts is made on the basis of input-output (I-O) accounting tables. These matrices show the pattern of purchases and sales between industries in the economy. Base tables are constructed at a national level, and tables for smaller regions are derived by regionalizing the core BEA tables to reflect inter-regional purchasing patterns.

0p trinhcaidat 19-04-2013 59 5   Download

The idea of using markets and pricing computer re- sources is quite old. Pricing policies received consid- erable attention at the dawn of modern multi-user time sharing systems. Papers in the late 1960’s were dedi- cated to automated pricing policies for computer time [18, 19, 20]. As research, this work was short-lived. The complexity of these schemes relative to their benefit, combined with the environment of time-shared systems (mostly cooperative, mostly controlled by a single en- tity) quickly made pricing for shared resource allocation a low priority.

24p nhacsihuytuan 06-04-2013 43 3   Download

TheX-raystructureofnativecellobiohydrolase IB(CBHIB) from the filamentous fungus Talaromyces emersonii,PDB 1Q9H,was solved to2.4 A ˚ bymolecular replacement. 1Q9H is a glycoprotein that consists of a large, single domain with dimensions of
60 A ˚ ·40 A ˚ ·50 A ˚ andanoverall b-sandwich structure, the characteristic fold of Family 7 glycosyl hydrolases (GH7). It is the first structure of a native glycoprotein and cellulase fromthis thermophilic eukaryote.

12p awards 05-04-2013 34 1   Download

Mass spectrometric studies on the N-linked glycans of aminopeptidase 1 from Manduca sextahave revealed unusual structures not previously observed on any insect glycoprotein. Structure elucidation of these oligosaccha-rides was carried out by high-energy collision-induced dissociation (CID) using a matrix-assisted laser desorp-tion/ionization time-of-flight/time-of-flight (MALDI-TOF/ TOF) tandem mass spectrometer.

18p awards 05-04-2013 33 3   Download

Gas1p is a glycosylphosphatidylinositol-anchored plasma membrane glycoprotein ofSaccharomyces cerevisiaeand is a representative of Family GH72 of glycosidases/transgly-cosidases, which also includes proteins from human fungal pathogens. Gas1p, Phr1-2p from Candida albicansand Gel1p fromAspergillus fumigatushave been shown to be b-(1,3)-glucanosyltransferases required for proper cell wall assembly andmorphogenesis. Gas1p is organized into three modules: a catalytic domain; a cys-richdomain; andahighly O-glycosylated serine-rich region. ...

11p awards 05-04-2013 45 3   Download

There are different glycosylated proteins in snake venoms, but no glycosylated representatives of a large family of three-fingered toxins have previously been detected. A new glycoprotein was isolated from the venom of the Thai cobra Naja kaouthia. MALDI MS of the glycoprotein contained an array of peaks in the range from
8900 to
9400 Da indicating its microheterogeneity. Carbohy-drate analysis showed the presence of mannose, galactose, N-acetylglucosamine, fucose and neuraminic acid.

10p dell39 03-04-2013 35 2   Download

GM-CSF is one of several naturally occurring glycoproteins that regulate leukocyte production, migration and function. It has been produced in different cell types, with different properties that depend on the production process used. The purpose of this work was to characterize the recombinant human GM-CSF from an engineered Chinese hamster ovary cell line grown in suspension and as adherent culture for the identification of the glycosylation sites and the defi-nition of the glycosidic moiety, including the degree of site occupancy....

13p dell39 03-04-2013 43 3   Download

Lactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role ofN-linked glycosylation in protection of LF against proteolysis, we compared the tryptic susceptibility of human LF (hLF) variants from human milk, expressed in human 293(S) cells or in the milk of transgenic mice and cows. The analysis revealed that recombinant hLF (rhLF) with mutations Ile130fiThr and Gly404fiCys was about twofold more susceptible than glycosylated and unglycosylated variants with the naturally occurring Ile130 and Gly404....

7p dell39 03-04-2013 38 3   Download

The romance of history pertains to no human annals more strikingly than to the early settlement of Virginia. The mind of the reader at once reverts to the names of Raleigh, Smith, and Pocahontas. The traveller's memory pictures in a moment the ivy-mantled ruin of old Jamestown. About the year 16--, the city of Jamestown, then the capital of Virginia, was by no means an unapt representation of the British metropolis; both being torn by contending factions, and alternately subjected to the sway of the Roundheads and Royalists.

85p chonguoinoiay1 02-04-2013 43 4   Download

The lightning streamed athwart the heavens in quick and vivid flashes. One peal of thunder after another echoed from cliff to cliff, while a driving storm of rain, wind and hail, made the face of nature black and dismal. There was something frightfully congenial in this uproar of the contending elements with the storm raging in Bacon's heart, as he rushed from the scene of the catastrophe we have just witnessed. The darkness which succeeded the lurid and sulphureous flashes was not more complete and unfathomable than the black despair of his own soul.

87p chonguoinoiay1 02-04-2013 64 2   Download