Glyoxalase pathway

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Glyoxalase 1 gene improves the antistress capacity and reduces the immune inflammatory response

Fish immunity is not only affected by the innate immune pathways but is also triggered by stress. Transport and loading stress can induce oxidative stress and further activate the immune inflammatory response, which cause tissue damage and sudden death.

13p vihagrid 30-01-2023 8 3 Download

Comparative analysis of glyoxalase pathway genes in Erianthus arundinaceus and commercial sugarcane hybrid under salinity and drought conditions

Glyoxalase pathway is a reactive carbonyl species (RCS) scavenging mechanism involved in the detoxification of methylglyoxal (MG), which is a reactive α-ketoaldehyde. In plants under abiotic stress, the cellular toxicity is reduced through glyoxalase pathway genes, i.e. Glyoxalase I (Gly I), Glyoxalase II (Gly II) and Glyoxalase III (Gly III).

16p visilicon2711 20-08-2021 6 1 Download

From methylglyoxal to pyruvate: A genome-wide study for the identification of glyoxalases and D-lactate dehydrogenases in Sorghum bicolor

The glyoxalase pathway is evolutionarily conserved and involved in the glutathione-dependent detoxification of methylglyoxal (MG), a cytotoxic by-product of glycolysis. It acts via two metallo-enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII), to convert MG into D-lactate, which is further metabolized to pyruvate by D-lactate dehydrogenases (D-LDH).

19p vijeeni2711 24-07-2021 3 0 Download
Comparative structure modeling of glyoxalase II protein of Oryza sativa

Glyoxalase I (gly I) and Glyoxalase II (gly II), zinc-binding enzymes of the glyoxalase pathway, carry out catabolism of methylglyoxal (MG). Gly II gene cloned from Oryza sativa has been widely used in genetic transformation experiments for salinity tolerance. This study could prove useful in further functional characterization of this important protein.

8p nguathienthan8 20-10-2020 12 2 Download
Genome-wide analysis and expression profiling of glyoxalase gene families in soybean (Glycine max) indicate their development and abiotic stress specific response

Glyoxalase pathway consists of two enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII) which detoxifies a highly cytotoxic metabolite methylglyoxal (MG) to its non-toxic form. MG may form advanced glycation end products with various cellular macro-molecules such as proteins, DNA and RNA; that ultimately lead to their inactivation.

25p vihashirama2711 21-05-2020 13 1 Download
Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation

The glyoxalase pathway ofLeishmania infantumwas kinetically character-ized as a trypanothione-dependent system. Using time course analysis based on parameter fitting with a genetic algorithm, kinetic parameters were estimated for both enzymes, with trypanothione derived substrates. A Kmof 0.253 mmand aVof 0.21lmolÆmin )1 Æmg )1 for glyoxalase I, and a Kmof 0.098 mmand aVof 0.18lmolÆmin )1 Æmg )1 for glyoxalase II, were obtained.

11p awards 06-04-2013 44 1 Download
APPLICATIONS OF IMMUNOCYTOCHEMISTRY

In a book titled Photosynthesis it is easy to forget that light is not simply the energy driving plant metabolism. Light also is the central environmental factor that affects plant size, shape and development. In fact, light activation of photomorphogenic signaling pathways sets the stage for photosynthesis and ensures the maintenance of the apparatus. The effects of specific wavebands of light exert their influence on plant biology from the molecular level all the way up to the higher morphological level, and even contribute to the canopy form as a whole.

330p conquynho32 15-09-2012 58 7 Download