Gold First

Overall survival (OS) is the gold standard to assess novel therapeutics to treat cancer. However, to identify early efficacy and speed up drug approval, trials have used progression-free survival (PFS) as a surrogate endpoint (SE). Herein, we aimed to examine if PFS could function as an OS surrogate in advanced Esophageal Squamous Cell Carcinoma (ESCC) treated with first-line immunochemotherapy.

13p vischultz 20-10-2023 3 1   Download

In this work, the biaxial SnO/ZnO nanowires in the average length of 5 µm, have been successfully synthesized on a ZnO-nanowire substrate using a chemical vapor deposition (CVD) system through a two-step process. First, ZnO nanowires were grown directly on the glass substrate with a gold catalyst.

11p viengels 25-08-2023 3 3   Download

Ebook Gold B2 First New Edition in the Gold series is a well-established exam preparation course that combines carefully graded exam preparation with thorough language and skills development. The new edition preparing students for B2 First has been improved in response to teacher feedback: 50% of the content is new with many new readings and listening, and all new visuals; there are 12 units rather than 14; the difficulty level for reading and listening is increased to match the level of the B2 First exam;...

202p duonghoanglacnhi 28-09-2022 24 6   Download

Ebook Gold first Exam Maximiser: recycles and reviews the coursebook grammar and vocabulary; provides exam practice in exam format with strategies and guidance; includes one complete practice test for timed practice in the run-up to the exam; contains additional Useful Language section; content tailored to the 2015 exam specifications;...

162p duonghoanglacnhi 28-09-2022 27 6   Download

Ebook Gold first provides: content tailored to the 2015 exam specifications; fast-paced syllabus with comprehensive exam coverage; stimulating discussion-rich topics; strong focus on vocabulary and chunks of language; extensive writing support including full reference with sample answers;...

209p duonghoanglacnhi 28-09-2022 34 5   Download

Ebook Gold First New Edition Teacher's Book provides: step-by-step guidance on how to use Gold in a blended classroom; full teaching notes with answer key, and seperate audio script section; plenty of ideas for warmer, extension and alternative activities; easy-to-use cross-references to additional practice in other components; two photocopiable worksheets with teaching notes for each unit;...

194p duonghoanglacnhi 28-09-2022 29 5   Download

This study reports for the first time the effect of different sodium halide salts (NaClO4, NaI, and Na2CO3) in the low concentration range (in the range of 10 −7 –1 M) on the swelling behavior of photo-crosslinked, surfaceimmobilized poly(N -isopropyl acrylamide) (PNIPAAm) terpolymer layers. PNIPAAm terpolymer (consisting of N - isopropylacrylamide, methacrylic acid, and 4-methacryloxybenzophenone) was synthesized via free radical polymerization. The PNIPAAm terpolymer layers were prepared on gold substrates via spin coating and crosslinked and surface attached via UV radiation.

11p tudichquannguyet 29-11-2021 7 1   Download

Due to environmental concerns, increasing attention has been focused on the application and preparation of biobased polymers and their blends. In this study, cellulose, the most spread biopolymer on Earth, was used in the preparation of novel cotton/polypropyleneAu and cotton/polyethylene-Au nanocomposites via a green mechanochemical approach. First, mechanoradicals were generated by ball milling of the cotton and thermoplastics under cryo conditions, and then, these radicals were used in the reduction of Au ions to Au nanoparticles (Au NPs).

13p tudichquannguyet 29-11-2021 6 0   Download

Electronic structures of a series of three homodinuclear platinum(II), palladium(II) and gold(I) complexes featuring Janus-type benzoxazolin-2-ylidene bridges and N,N-diisopropyl benzimidazolin-2-ylidene auxiliary ligands have been investigated. The gas-phase molecular structures of all compounds were first optimized using B3PW91 functional and SDD/6-31G(d) combination of basis sets. The nature of their frontier orbitals were then examined.

8p kequaidan11 07-04-2021 8 1   Download

There has been no gold standard of the initial treatment strategy for acute patellar dislocation (APD) with osteochondral fracture (OCF). Hence the study aim is firstly, to review and compare clinical outcomes of patients who underwent conservative treatment for APD with or without OCF. Secondly, to characterize the location and size of fracture fragment.

8p vimariana2711 22-12-2020 11 1   Download

First metatarso-phalangeal joint fusion is the current gold standard for severe hallux rigidus. Data regarding the union rate and the re-operation rate when IOFix (an Intra-osseous fixation device, Extremity medical, New Jersey, USA) is used for hallux rigidus fusion is limited but promising. The aim of this study was to review our outcomes with the IOFix implant.

8p vimariana2711 22-12-2020 11 0   Download

In case of high grade non-muscle invasive bladder cancer (HG-NMIBC), intravesical BCG represents the first-line treatment; despite the “gold” standard therapy, up to 50% of patients relapse, needing radical cystectomy.

9p viputrajaya2711 22-06-2020 8 1   Download

Inorganic or inorganic-organic hybrid nanomaterials have great potential for applications in the biomedical fields. Biological half-life is an essential pharmacokinetic parameter for these materials to function in vivo. Compared to inductively coupled plasma mass spectrometry (ICP-MS), which is the gold standard, laser-induced breakdown spectroscopy (LIBS) is a faster and more efficient elemental detection method. We investigated an efficient way to quantify the metabolic rate using LIBS.

9p covid19 14-06-2020 15 2   Download

The study employs the Box-Jenkins Methodology to forecast South African gold sales. For a resource economy like South Africa where metals and minerals account for a high proportion of GDP and export earnings, the decline in gold sales is very disturbing. Box-Jenkins time series technique was used to perform time series analysis of monthly gold sales for the period January 2000 to June 2013 with the following steps: model identification, model estimation, diagnostic checking and forecasting. Furthermore, the prediction accuracy is tested using mean absolute percentage error (MAPE).

7p chauchaungayxua2 09-01-2020 33 0   Download

The study was carried out at the experimental farm of the Department of Floriculture and Landscape Architecture, Dr YS Parmar University of Horticulture and Forestry, Nauni, Solan. The data was taken for four flushes, that is, Flush I (November, 2017), Flush II (April, 2018), Flush III (June, 2018) and Flush IV (August, 2018). The cultivars selected for the experiment were Avalanche, Confetti, Corvette, First Red, Gavanna, Gold Strike, Hollywood, Nobelesse, Peach Avalanche, Sweet Avalanche, Taj Mahal and Tineke.

9p nguaconbaynhay1 08-12-2019 10 1   Download

The gold standard for the detection of urothelial carcinoma is represented by urethro-cystoscopy and biopsy. Both procedures are invasive and expensive and therefore cytology is often used as first approach to investigate on a possible neoplasia, being a safe and cost-effective diagnostic modality of evaluation.

6p vilusaka2711 19-11-2019 11 0   Download

A new approach has been developed for the preparation of mixed-mode stationary phases to separate proteins. The pore surface of monolithic poly(glycidyl methacrylate-co-ethylene dimethacrylate) capillary columns was functionalized with thiols and coated with gold nanoparticles. The final mixed mode surface chemistry was formed by attaching, in a single step, alkanethiols, mercaptoalkanoic acids, and their mixtures on the free surface of attached gold nanoparticles. Use of these mixtures allowed fine tuning of the hydrophobic/hydrophilic balance.

8p trinhthamhodang1 16-11-2019 14 1   Download

first certificate gold practice exams practice exams consist of a set of five practice exams which are free-standing, in line with the exact specifications of the revised exam and designed to look as similar as possible to the real exam.invite you to consult the documentation.

129p emelikov 21-08-2016 304 42   Download

Document presentation of content: Epidemiology—global aspects, diagnosis of Helicobacter pylori infection, management of helicobacter pylori infection, choosing an eradication regimen, complianc, cascade Information

15p vovanvovan2013 13-05-2016 46 1   Download

Natural language generation (NLG) systems are notoriously hard to evaluate. On the one hand, simply comparing system outputs to a gold standard is not appropriate because there can be multiple generated outputs that are equally good, and finding metrics that account for this variability and produce results consistent with human judgments and task performance measures is difficult (Belz and Gatt, 2008; Stent et al., 2005; Foster, 2008). On the other hand, lab-based evaluations with human subjects to assess each aspect of the system’s functionality are expensive and time-consuming. ...

4p bunthai_1 06-05-2013 55 2   Download