Growth genes
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Predicting short-term efficacy and intracranial progression-free survival (iPFS) in epidermal growth factor receptor gene mutated (EGFR-mutated) lung adenocarcinoma patients with brain metastases who receive third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy was of great significance for individualized treatment.
15p vishanshan 27-06-2024 1 1 Download
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Several publications suggest that UTP11 may be a promising gene engaged for involvement of hepatocellular carcinoma (HCC) pathology. However, there are extremely limited biological, mechanistic and clinical studies of UTP11 in HCC.
13p vishanshan 27-06-2024 1 1 Download
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Ras gene mutation and/or overexpression are drivers in the progression of cancers, including colorectal cancer. Blocking the Ras signaling has become a significant strategy for cancer therapy. Previously, we constructed a recombinant scFv, RGD-p21Ras-scFv by linking RGD membrane-penetrating peptide gene with the anti-p21Ras scFv gene.
16p vishanshan 27-06-2024 1 1 Download
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Mitochondria, which serve as the fundamental organelle for cellular energy and metabolism, are closely linked to the growth and survival of cancer cells. This study aims to identify and assess Siderofexin1 (SFXN1), an unprecedented mitochondrial gene, as a potential prognostic biomarker for lung adenocarcinoma (LUAD).
20p vishanshan 27-06-2024 2 1 Download
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p vikoch 27-06-2024 1 1 Download
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The study was carried out to clone sheep cytokine genes for protein expression in mammalian cell culture. Once expressed, it is hypothesized that these proteins, when added to a primary mast cell culture, will allow the growth of these cells.
15p viambani 18-06-2024 2 0 Download
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Ebook "VEGF in development" is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit.
116p tracanhphuonghoa1007 22-04-2024 4 2 Download
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Ebook "Breast cancer chemosensitivity" include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents.
187p tracanhphuonghoa1007 22-04-2024 3 1 Download
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Glutamine synthetase (EC 6.3.1.2) is an enzyme which assimilates ammonium into amino acids. Therefore, GS plays an essential role in the metabolism of nitrogen. In vascular plants, GS is devided into two groups: cytosol - located isoform (GS1) and plastid – located isoform (GS2). Surveys have shown that GS1 gene was used widely to generate transgenic plants. Effects on the growth characteristics of GS1 transgenic plants have been reported in many researches.
7p vilarry 01-04-2024 6 1 Download
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The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors.
19p vioraclene 31-03-2024 3 2 Download
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Alzheimer’s disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying common genetic variants driving differences in transcript expression that confer AD risk is necessary to elucidate AD mechanism and develop therapeutic interventions.
15p vibransone 28-03-2024 2 2 Download
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Ebook "Phytochemicals, plant growth, and the environment (Phytochemicals, plant growth, and the environment, Volume 42)" includes a total of seven articles, many, but not all, based on talks presented at the 50th annual meeting of the PSNA. As was seen in RAP volume 41, These seven Perspectives give a very good picture of the breadth of plant (bio)chemistry research in North America, which is also indicative of the state of the field worldwide.
179p manmanthanhla0201 26-02-2024 1 1 Download
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Ebook "Biology of domestic animals" touches on all of these, with a particular focus on topics such as domestic animals as comparative models to humans, molecular regulation of growth, metabolic efficiency, reproduction, and the impact of stress on growth and development. The book concludes with a discussion on the current and future directions for researchers.
371p lucchinguyen 28-12-2023 7 3 Download
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Ebook "Fusarium head blight in Latin America" presents the current state of knowledge regarding mycological aspects that make wheat-Fusarium interaction, such as hyphal growth, morphogenesis in germinating spores, visualization of enzymatic hydrolysis, production of mycotoxins, inhibition of the hyphal growth by antagonist microorganisms, use of natural substances or by modification of the host resistance, as well as genetic analysis and expression of genes that regulate the infection.
311p lucchinguyen 28-12-2023 6 2 Download
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Vast amounts of rapidly accumulating biological data related to cancer and a remarkable progress in the field of artificial intelligence (AI) have paved the way for precision oncology. Our recent contribution to this area of research is CancerOmicsNet, an AI-based system to predict the therapeutic effects of multitargeted kinase inhibitors across various cancers.
17p vileonardodavinci 23-12-2023 2 2 Download
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Dysregulation of inhibitor of differentiation/DNA binding (ID) genes is linked to cancer growth, angiogenesis, invasiveness, metastasis and patient survival. Nevertheless, few investigations have systematically determined the expression and prognostic value of ID genes in acute myeloid leukemia (AML).
12p vileonardodavinci 23-12-2023 2 2 Download
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Epidermal growth factor receptor (EGFR) amplifcation refers to the copy number increase of EGFR gene, and is often identified as a “bypass” way of Epidermal growth factor receptor Tyrosine kinase inhibitors (EGFRTKI) resistance. We aimed to explore the effect of EGFR amplification on EGFR mutation treatment-naive advanced non-squamous non-small cell lung cancer (NSCLC) patients.
10p vileonardodavinci 23-12-2023 3 2 Download
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RAS mutations affect prognosis in patients with metastatic colorectal cancer (mCRC) and have been identified as strong negative predictive markers for anti-epidermal growth factor receptor monoclonal antibody (antiEGFR mAb) therapy, but many tumors containing wild-type RAS genes still do not respond to these therapies.
27p vileonardodavinci 23-12-2023 7 2 Download
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Aberrant fibroblast growth factor receptor (FGFR) signaling can substantially influence oncogenicity. Despite that FGFR gene abnormality is often detected by cancer genome profiling tests, there is no tumor-agnostic approval yet for these aberrations. E7090 (tasurgratinib) is an orally available selective tyrosine kinase inhibitor of FGFR1-3.
7p vialfrednobel 23-12-2023 4 3 Download
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Hexokinase 2 (HK2) is an enzyme that catalyses the conversion of glucose to glucose-6-phosphate, which has been found to be associated with malignant tumour growth. However, the potential immunological and clinical significance of HK2, especially in terms of prognostic prediction for patients with glioma, has not been fully elucidated.
20p vialfrednobel 23-12-2023 6 3 Download