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Head and neck squamous cell cancer
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Cervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in the UK for locally advanced cervical cancer is concurrent chemoradiotherapy with weekly cisplatin, yet 5-year overall survival rates are only 65% with a distant relapse rate of 50%.
10p
vishanshan
27-06-2024
1
1
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Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and also have great influence on the composition of the tumor microenvironment and immune cell functions.
13p
vishanshan
27-06-2024
1
1
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Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.
11p
vishanshan
27-06-2024
3
1
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The study aimed to assess the impact of parotid lymph nodes (LNs) on the prognosis of patients with cutaneous squamous cell carcinomas of the head and neck (HNcSCC), and to develop an alternative LN assessment method to enhance locoregional control (LRC) and overall survival (OS) stratification.
10p
vishanshan
27-06-2024
1
1
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This study aimed to develop and validate a machine learning (ML)-based fusion model to preoperatively predict Ki-67 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) using multiparametric magnetic resonance imaging (MRI).
14p
vikoch
27-06-2024
3
1
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Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease.
18p
vibransone
28-03-2024
9
2
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Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermethylation in HPV(+) oropharyngeal cancers, but only few consistent target genes have been so far described, and the evidence of a functional impact on gene expression is still limited.
12p
vioraclene
31-03-2024
3
1
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Lower lip squamous cell carcinoma is a significant subtype of head and neck cancer, constituting about 25–30% of cases. Traditional surgical methods, like primary closure, have limitations in managing large resections of lip tumors.
6p
vitiki
30-01-2024
5
2
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Immune checkpoint inhibitors might cause immune-related adverse events that are still largely unknown. The study presents the first reported case of type 1 diabetes in a patient with head and neck squamous cell carcinoma treated with pembrolizumab monotherapy, in Japan.
6p
vitiki
30-01-2024
5
2
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The optimal duration of anti-PD-1 for cancer therapy has not been tested, especially when using combination therapy. Epidermal growth factor receptor (EGFR) pathway blocker was the top compound that enhanced T-cell killing of tumor cells in a high-throughput immune-oncology screen, possibly by stimulate the antigen presentation machinery and other mechanisms.
9p
vileonardodavinci
23-12-2023
2
2
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Recurrent/ metastatic squamous cell carcinoma of head and neck (R/M SCCNH) is still a difficult-totreat disease with poor clinical outcomes and limited treatment choices. In view of locoregional recurrent versus dis‑ tant metastatic SCCHN, the therapeutic efcacy of cetuximab-containing regimen and relevant prognostic factors for these two groups may be different.
10p
vileonardodavinci
23-12-2023
4
2
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New concepts for a more efective anti-cancer therapy are urgently needed. Experimental faws rep‑ resent a major counter player of this development and lead to inaccurate and unreproducible data as well as unsuc‑ cessful translation of research approaches into clinics. In a previous study we have created epithelial cell cultures from head and neck squamous cell carcinoma (HNSCC) tissue.
13p
vileonardodavinci
23-12-2023
2
2
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Tumor microenvironment (TME) is of great importance to regulate the initiation and advance of cancer. The immune infiltration patterns of TME have been considered to impact the prognosis and immunotherapy sensitivity in Head and Neck squamous cell carcinoma (HNSCC). Whereas, specific molecular targets and cell components involved in the HNSCC tumor microenvironment remain a twilight zone.
18p
vileonardodavinci
23-12-2023
5
2
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Postoperative chemoradiotherapy (CRT) is a standard therapy for patients with high-risk factors for head and neck squamous cell carcinoma, including positive margin and extra-nodal extension (ENE). However, the prognostic impact of the number of pathological metastatic lymph nodes (pLNs) in hypopharyngeal carcinoma (HPC) is unclear.
6p
vileonardodavinci
23-12-2023
4
3
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Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosis of HNSCC has been questioned and remains unclear.
13p
vileonardodavinci
23-12-2023
7
3
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As a human tumor disease, head and neck squamous cell carcinoma (HNSCC) is associated with a high mortality rate worldwide. Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptor proteins and exert their biological effects following activation by nicotine. We aimed to construct a prognostic signature based on the expression of nAChRs among smokers with HNSCC.
12p
vileonardodavinci
23-12-2023
5
3
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Most patients diagnosed with head and neck tumor will present with locally advanced disease, requiring multimodality therapy. Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived signals, such as inflammatory cytokines and growth factors.
10p
vileonardodavinci
23-12-2023
6
2
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Immune checkpoint inhibitors of programmed cell death protein 1 (PD-1) represent a signifcant break‑ through in treating head and neck squamous cell carcinoma (HNSCC), with long-lasting responses and prolonged survival observed in frst- and second-line therapy. However, this is observed in
9p
vileonardodavinci
23-12-2023
6
2
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Markers that can be used to evaluate the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) remain undefined. Objective This study aimed to investigate the prognostic impact of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in patients with HNSCC who underwent surgery-based treatment for the first time.
9p
vileonardodavinci
23-12-2023
6
3
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Head and neck squamous carcinoma (HNSC) poses a significant public health challenge due to its substantial morbidity. Nevertheless, despite advances in current treatments, the prognosis for HNSC remains unsatisfactory. To address this, single-cell RNA sequencing (RNA-seq) and bulk RNA-seq data combined with in vitro studies were conducted to examine the role of MYO5A (Myosin VA) in HNSC.
14p
vileonardodavinci
23-12-2023
5
3
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