Hematological malignancy
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Determination of drug-related problems in the hematology service: A prospective interventional study
Patients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects.
8p vishanshan 27-06-2024 2 1 Download
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Adoptive cell therapy has achieved great success in treating hematological malignancies. However, the production of chimeric antigen receptor T (CAR-T) cell therapy still faces various difficulties. Natural killer (NK)-92 is a continuously expandable cell line and provides a promising alternative for patient’s own immune cells.
12p vishanshan 27-06-2024 2 1 Download
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Nervous system toxicity (NST) is one of the most frequent and dangerous side effects of chimeric antigen receptor T-cell (CAR-T) therapy, which is an effective treatment for related tumors in most relapsed/refractory (r/r) hematologic malignancies. Current clinical trial data do not fully reflect the real-world situation. Therefore, this study evaluated the NST of CAR-T therapy using the FDA Adverse Event Reporting System (FAERS).
11p vishanshan 27-06-2024 2 1 Download
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Non-Hodgkin's lymphoma (NHL) is a common hematological malignancy that develops in the lymphatic system. A20, CYLD, IFN-γ, JAK2, PI3KCA, and TP53 are known as inflammationrelated genes in autoimmune diseases and cancers. In the end, 126 patients with NHL and 109 healthy individuals with well-characterized clinical profiles were enrolled.
7p visergeyne 18-06-2024 0 0 Download
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Acute myeloid leukemia (AML), caused by the abnormal proliferation of immature myeloid cells in the blood or bone marrow, is one of the most common hematologic malignancies. Currently, the interactions between malignant myeloid cells and the immune microenvironment, especially T cells and B cells, remain poorly characterized.
11p vibransone 28-03-2024 4 2 Download
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Ebook "Advances in biology and therapy of multiple myeloma - Volume 1: Basic science" despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.
322p duongthandue0501 28-02-2024 3 1 Download
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Ebook "Mesenchymal stromal cells: Biology and clinical applications" have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.
697p duongthandue0501 28-02-2024 3 1 Download
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Tumor lysis syndrome is an oncologic emergency that classically occurs following cancer therapy, although spontaneous tumor lysis syndrome can also occur in malignancies, albeit rarely. Spontaneous tumor lysis syndrome has previously been reported in some hematologic malignancies, but it rarely happens in solid tumors and seems to be associated with a higher mortality rate.
5p vigojek 02-02-2024 3 1 Download
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Pericardial neoplastic involvement is rarely related to primary tumors of the pericardium and is most often caused by spread from other primary sites, such as lung and breast carcinomas, hematological malignancies (lymphoma and leukemia), and melanoma.
4p vilazada 31-01-2024 4 2 Download
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Progressive multifocal leukoencephalopathy is a rare central nervous system disease, resulting from reactivation of latent John Cunningham virus. Monoclonal antibodies have recently become a relevant risk factor for developing progressive multifocal leukoencephalopathy.
7p vilazada 31-01-2024 4 2 Download
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Hematological malignancies are an infrequent but important cause of liver dysfunction. There are several mechanisms by which this can occur, including direct malignant infiltration of the hepatic parenchyma and/ or vasculature, vanishing bile duct syndrome, and paraneoplastic hepatitis.
7p vitiki 30-01-2024 3 2 Download
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The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response. ISR activation was reported in neurological disorders and solid tumors; however, the function of ISR and its role as a possible therapeutic target in hematological malignancies still remain largely unexplored.
17p vileonardodavinci 23-12-2023 4 3 Download
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A worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characteristics of HM in a French West Indies territory, we have performed analysis through Martinique’s population-based cancer registry database.
10p vileonardodavinci 23-12-2023 4 2 Download
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A new type of immune cell transplantation called allogeneic NK cell infusion is proposed as a potential universal off-the-shelf cell product for adoptive immune cell therapy in hematologic malignancies.
10p vileonardodavinci 23-12-2023 3 2 Download
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Allogeneic stem cell transplantation (allo-SCT) is a potentially lifesaving treatment for high-risk hematological malignancy, but survivors experience markedly elevated rates of cardiovascular disease and associated functional impairment.
17p vialfrednobel 23-12-2023 5 3 Download
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Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life.
15p vialfrednobel 23-12-2023 6 4 Download
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This study aims to assess the nutritional status of patients during the different phases of the Chimeric Antigen Receptor (CAR)-T cell therapy and to identify prominent risk factors of hypoalbuminemia in patients after CAR-T treatment. The clinical consequences of malnutrition in cancer patients have been highlighted by growing evidence from previous clinical studies.
8p vialfrednobel 23-12-2023 5 3 Download
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Part 1 book "Cowell and Tyler's diagnostic cytology and hematology of the dog and cat" includes content: Sample collection and preparation, cell types and criteria of malignancy, selected infectious agents, round cells, cutaneous and subcutaneous lesions, eyes and associated structures,nasal exudates and masses, oropharynx and tonsils, eyes and associated structures,... and other contents.
264p oursky08 06-11-2023 6 4 Download
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Part 2 book "Cowell and Tyler's diagnostic cytology and hematology of the dog and cat" includes content: Transtracheal and bronchoalveolar washes, the gastrointestinal tract, the pancreas, the lung and intrathoracic structures, female reproductive tract,examination of the urine sediment, peripheral blood smears, bone marrow, molecular methods in lymphoid malignancies,.... and other contents.
314p oursky08 06-11-2023 7 3 Download
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Precursor B-cell acute lymphoblastic leukemia (pre-B ALL) is the most common hematological malignancy in children. Cellular metabolic reorganization is closely related to the progression and treatment of leukemia.
16p vischultz 20-10-2023 4 1 Download