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Hemolytic activity
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In this study, we synthesized and compared their antimicrobial and hemolytic activity. Furthermore, the data was analyzed and interpreted based on the helical wheel model that represents the peptide secondary structure.
11p
dianmotminh02
03-05-2024
4
1
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The synthesized compounds' enzyme inhibition potential was tested against a-glucosidase, AChE, and BChE enzymes. As illustrated from the results of IC50, these compounds are observed as the active inhibitory potential for these enzymes. The cytotoxic activity by hemolytic Assay revealed that these compounds have mild exposure to cytotoxicity on RBCs.
10p
visergey
02-04-2024
0
0
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In the context of sources for natural products discovery are going scarcer, exploiting biotechnologically potential compounds from marine microbial symbionts is considered a relatively new trend. In our study a total of fifteen fungal strains were isolated from marine algal samples belonging to species Kappaphycus cottonii, K. striatus, Gracilaria eucheumatoides and Betaphycus gelatinus collected in Nha Trang in 2017.
7p
vicaptainmarvel
21-04-2023
5
3
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Products containing beneficial bacteria for humans have been widely used recently. The bacteria in these products generally belong to the genus Lactobacillus. Among the species of this genus, Lactobacillus casei attracts a lot of interest due to their valuable properties. With these properties, many L. casei strains can be used as probiotics.
11p
vidudley
20-02-2023
3
2
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In patients with paroxysmal nocturnal hemoglobinuria (PNH), the membrane-attack complex (MAC) formed on red blood cells (RBCs) causes hemolysis due to the patient’s own activated complement system by an infection, inflammation, or surgical stress. The efficacy of transfusion therapy for patients with PNH has been documented, but no studies have focused on the perioperative use of salvaged autologous blood in patients with PNH.
4p
vizhangzhidong
29-12-2021
14
1
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The therapeutic applications of 1,2,4-triazoles motivated us to synthesize some new derivatives. Two series of S -substituted derivatives (8a–8j, 12a–12i) of 5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-4-phenyl-4H -1,2,4-triazol3-thiol (6) have been synthesized and evaluated for their biological potential.
20p
tudichquannguyet
29-11-2021
8
1
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The objective of this study is to synthesize ZnO and Mg doped ZnO(Zn1−xMgxO) nanoparticles via the sol-gel method, and characterize their structures and to investigate their biological properties such as antibacterial activity and hemolytic potential.Nanoparticles (NPs) were synthesized by the sol-gel method using zinc acetate dihydrate (Zn(CH3COO)2.2H2O) and magnesium acetate tetrahydrate (Mg(CH3COO)2.4H2O) as precursors. Methanol and monoethanolamine were used as solvent and sol stabilizer, respectively.
23p
tudichquannguyet
29-11-2021
9
1
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A total of 120 fresh water fish samples were evaluated for the presence of Aeromonas spp. A. hydrophila, A. caviae, and A. veronii bv. sobria were isolated from the gills, intestines, livers, and skins of fish, and 78 isolated Aeromonas spp. strains were further examined for siderophore, hemolytic, protease, and pyrazinamidase activities and antibiotic resistance.
10p
vivant2711
15-02-2019
32
1
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Dendrimeric peptides selective for microbial surfaces have been developed to achieve broad antimicrobial activity and low hemolytic activity to human erythrocytes. The dendrimeric core is an asymmetric lysine branching tethered with two to eight copies of a tetrapeptide (R4) or an octapeptide (R8). The R4 tetrapeptide (RLYR) contains a putative microbial surface recognition BHHB motif (B ¼ basic, H ¼ hydrophobic amino acid) found in protegrins and tachyplesins whereas the octapeptide R8 (RLYRKVYG) consists of an R4 and a degenerated R4 repeat....
10p
research12
01-06-2013
36
5
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The interactionofmany lytic cationic antimicrobial peptides with their target cells involves electrostatic interactions, hydrophobic effects, and the formation of amphipathic sec-ondary structures, such asahelices orbsheets. We have shown in previous studies that incorporating 30% D-aminoacids intoashortahelical lyticpeptidecomposedof leucine and lysine preserved the antimicrobial activity of the parent peptide, while the hemolytic activity was abolished.
12p
research12
23-04-2013
33
1
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The rhesus (Rh) blood group antigens are of considerable importance in transfusion medicine as well as in newborn or autoimmune hemolytic diseases due to their high antigenicity. We identified a major DNaseI hypersensitive site at the 5¢ flanking regions of bothRHDandRHCEexon 1. A 34 bp fragment located at)191 to)158 from a translation start posi-tion, and containing the TCCCCTCCC sequence, was involved in enhan-cing promoter activity, which was assessed by luciferase reporter gene assay.
0p
awards
06-04-2013
28
1
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The role of renal expression of the glycosphingolipid verotoxin receptor, globotriaosylceramide, in susceptibility to verotoxin-induced hemolytic uremic syndrome is unclear. We show that a single glycosphingolipid can discriminate multiple specific ligands. Antibody detection of globo-triaosylceramide in renal sections does not necessarily pre-dict verotoxin binding.
13p
dell39
03-04-2013
40
3
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Cyclotides are a family of bioactive plant peptides that are characterized by a circular protein backbone and three conserved tightly packed disulfide bonds. The antimicrobial and hemolytic properties of cyclotides, along with the relative hydrophobicity of the peptides, point to the biological mem-brane as a target for cyclotides.
15p
inspiron33
26-03-2013
54
3
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Volvatoxin A2, a pore-forming cardiotoxic protein, was isolated from the edible mushroomVolvariella volvacea. Previous studies have demonstrated that volvatoxin A consists of volvatoxin A2 and volvatoxin A1, and the hemolytic activity of volvatoxin A2 is completely abolished by volvatoxin A1 at a volvatoxin A2⁄volvatoxin A1 molar ratio of 2.
12p
inspiron33
25-03-2013
27
2
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Primary care clinicians often provide continuity of care, emphasize prevention, and address chronic illness with their patients. All these endeavors require the active involvement of the patient in treatment planning and adherence. An active and healthy therapeutic alliance that recognizes that patients are the chief consumers of health care is essential in this regard. This critical role in directing one’s health care can be either facilitated or complicated by a patient’s emotional, cognitive, and behavioral strengths or weaknesses (ie, mental health).
230p
hyperion75
21-01-2013
55
4
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Mitomycin C undergoes reduction of its quinone function to generate a bifunctional DNA alkylating agent. It is a broadly active antineoplastic agent with a number of unpredictable toxicities, including delayed bronchospasm 12–14 h after dosing and a chronic pulmonary fibrosis syndrome more frequent at doses of 50–60 mg/m2. Cardiomyopathy has been described, particularly in a setting of prior radiation therapy. A hemolytic/uremic syndrome carries an ultimate mortality rate of 25–50% and is poorly treated by conventional component support and exchange transfusion.
5p
konheokonmummim
03-12-2010
60
3
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