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Heparan sulfate proteoglycan
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Glypican-1 is a heparan sulfate proteoglycan that is overexpressed in prostate cancer (PCa), and a variety of solid tumors. Importantly, expression is restricted in normal tissue, making it an ideal tumor targeting antigen.
13p
vichaeng2711
29-04-2021
8
1
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The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are involved in the growth, invasion and metastatic properties of cancerous cells. The purpose of this study is to increase knowledge of HSPG alterations in breast cancer.
16p
vijisoo2711
29-09-2020
10
1
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Glypican 3 (GPC3) is a member of the family of glypican heparan sulfate proteoglycans (HSPGs). The GPC3 gene may play a role in controlling cell migration, negatively regulating cell growth and inducing apoptosis. GPC3 is downregulated in several cancers, which can result in uncontrolled cell growth and can also contribute to the malignant phenotype of some tumors.
11p
vilisa271
22-09-2020
10
1
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Heparan sulfate proteoglycans (HSPGs) are complex molecules involved in the growth, invasion and metastatic properties of cancerous cells. This study analyses the alterations in the expression patterns of these molecules in right sided colorectal cancer (CRC), both metastatic and non-metastatic.
20p
vimoscow2711
29-08-2020
9
0
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Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics.
14p
vimale2711
21-08-2020
11
1
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Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
17p
vibaku2711
22-07-2020
10
2
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Adeno-associated virus (AAV) vectors have been utilized extensively in gene therapy and gene function studies, as strong transgene expression is a prerequisite for positive outcomes. AAV8 was reported as the most efficient AAV serotype for transduction of the liver, brain and muscle compared with other serotypes.
6p
viwashington2711
04-12-2019
15
0
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Heparan sulfate proteoglycans (HSPG) nằm ở trên bề mặt tế bào hoặc trong khoảng gian bào của tất cả các mô động vật. HSPG và các protein liên kết với chúng tham gia vào nhiều quá trình sinh học của tế bào như: sự liên kết tế bào - tế bào, quá trình phân bào, biệt hóa, sự di chuyển và các quá trình sinh bệnh lý của tế bào [1, 2, 6]. Khoảng gian bào là nơi lưu giữ và giải phóng các enzyme proteinase, các chất ức chế và các yếu tố phát triển tế bào. Những tác nhân gây ra sự giải phóng các yếu tố...
7p
sunshine_3
28-06-2013
29
2
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In seminiferous tubules, Sertoli cells provide structural and nutritional support for the developing germinal cells. Cellto-cell signaling and cell adhesion require proteoglycans expressed at the cell membrane. A preliminary biochemical and structural approach indicated that cell surface proteoglycans are mostly heparan sulfate proteoglycans (HSPG). Glypican-1, syndecans-1 and -4 were identified using a molecular approach.
9p
research12
01-06-2013
39
4
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Basic ®broblast growth factor (bFGF) regulates diversi®ed biological functions in rat Sertoli cells. This report demon-strates that bFGF inhibits steroidogenesis in developing rat Sertoli cells. Follicle stimulating hormone (FSH)-stimulated estradiol production was reduced by bFGF. Moreover, the amount of cytochrome P450 aromatase, responsible for the irreversible transformation of androgens into estrogens, is decreased by bFGF at the transcriptional level.
10p
research12
23-04-2013
30
1
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Heparanase is an endo-b-D-glucuronidase capable of cleaving heparan sul-fate side chains at a limited number of sites, yielding heparan sulfate frag-ments of still appreciable size. Importantly, heparanase activity correlates with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination as a consequence of heparan sulfate cleavage and remod-eling of the extracellular matrix and basement membrane underlying epithe-lial and endothelial cells.
14p
viettel02
19-02-2013
35
2
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Scientifi c interest and curiosity for proteoglycan research has dramatically increased over the past decades, these molecules being no more considered as a scaffold for the cells of a given tissue, but more as a reservoir for growth factors and cytokines modulating their activation status and turnover. For example, heparin and other related heparan sulfate molecules are increasingly being recognized as important modulators of many signaling pathways.
374p
hotmoingay
04-01-2013
55
5
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans...
8p
thulanh12
13-10-2011
36
3
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