Hepatitis C viral infections

Thalassemia is one of commonest hereditary disease worldwide, prevalent in humid climates and affects all races. The Transfusion Dependent Thalassemias require regular blood transfusion to survive. The thalassemia patients require lifelong blood transfusion on regular basis- usually administered every 2 to 5 weeks. Due to regular blood transfusion, transfusion transmitted disease e.g. Hepatitis B Virus (HBV), Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) infections can occur.

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Hepatitis C virus (HCV) exists in different forms in the circulation of infec-ted people: lipoprotein bound and lipoprotein free, enveloped and non-enveloped. Viral particles with the highest infectivity are associated with lipoproteins, whereas lipoprotein-free virions are poorly infectious.

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