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Hepatoma cells
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Newcastle disease virus (NDV) is an oncolytic virus that can inhibit cancer cell proliferation and kill cancer cells. The NDV nonstructural V protein can regulate viral replication; however, whether the V protein contributes to NDV oncolysis is unclear.
10p
vischultz
20-10-2023
4
1
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The acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of BC were studied. Cytotoxicity of BC was evaluated in cultured C3A hepatoma cells (HepG2/C3A) using a lactate dehydrogenase (LDH) activity assay. Acute toxicity was tested in adults Wistar rats treated with a single dose of BC.
5p
vihermione
06-01-2023
13
3
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Cancer stem cells (CSCs) are thought to play important roles in carcinogenesis, recurrence, metastasis, and therapy-resistance. We have successfully induced cancer stem-like sphere cells (CSLCs) which possess enhanced chemoresistance and metastatic potential.
13p
vikolindagrabar
27-07-2022
3
1
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The behavior of cells in vivo is complex and highly dynamic, as it results from an interplay between intercellular matrix proteins with surface receptors and other microenvironmental cues.
15p
vilichoo2711
23-06-2021
7
1
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A malfunction of RXRα due to phosphorylation is associated with liver carcinogenesis, and acyclic retinoid (ACR), which targets RXRα, can prevent the development of hepatocellular carcinoma (HCC). Activation of PI3K/Akt signaling plays a critical role in the proliferation and survival of HCC cells.
11p
vijennie2711
29-09-2020
10
2
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Hepatitis B virus (HBV)-X protein(HBx) is a transactivator of host several cellular genes including alpha-fetoprotein(AFP) and AFP receptor(AFPR) which contributes to HBV-associated tumor development. The expression of AFP/AFPR are correlated with hepatocellular carcinoma(HCC)-initial cells.
9p
vialabama2711
21-09-2020
9
0
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It is generally accepted that the energy resources of cancer cells rely on anaerobic metabolism or the glycolytic system, even if they have sufficient oxygen. This is known as the Warburg effect. The cells skillfully survive under hypoglycemic conditions when their circumstances change, which probably at least partly involves microRNA (miRNA)-mediated regulation.
13p
vimale2711
25-08-2020
11
2
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Evodiamine has gained wide interests recently because of its anti tumor activities. However, a superior bioavailability is required to achieve better efficacy due to its poor water solubility.
11p
vijiraiya2711
27-05-2020
10
1
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Cadmium (Cd) is a well known environmental and industrial toxicant causing damaging effects in numerous organs. In this study, we examined the role of heme oxygenase-1 (HO-1) in modulating the Cd-induced apoptosis in human hepatoma (HepG2) cells after 24 h exposure.
13p
vienzym2711
30-03-2020
11
2
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The mechanism of EphB4/ephrinB2 in the resistance of chronic myelogenous leukemia to imatinib keeps unknown. The imatinib resistant chronic myelogenous leukemia cell line-K562-R, was established. EphB4 receptor expression was detected in patients and resistant cells. Cell migration and drug sensitivity were tested in the EphB4 knockdown cells and mouse models.
9p
viwashington2711
04-12-2019
9
1
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We succeeded in large volume artificial cultivation of Onygena corvina. The appearance (shape, color, and size) of fruiting bodies of cultured bacteria was almost the same as that of wild one. We screened their metabolites for antiproliferative activities against nine human cancer cells in vitro. Culture filtrates (metabolite-containing media) of O. corvina were lyophilized and resuspended in phosphate buffer to investigate them in vitro. As a result, these metabolites effectively inhibited the growth of some cancer cells in a concentration-dependent manner.
10p
nguaconbaynhay1
04-12-2019
10
1
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We previously reported that modulation of cytokeratin18 induces pleomorphism of liver cells, higher cell motility, and higher drug sensitivity to sorafenib treatment of hepatoma cells. These relationships were established by in vitro experiments.
11p
vihasaki2711
12-11-2019
4
0
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β-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of β-glucan. Saccharomyces cerevisiae, baker’s yeast, is one of the commonly used sources of β-1,3-glucan. The aim of this work was to investigate S. cerevisiae β-glucan immunomodulatory activity against cancer cells.
5p
vikimsa
22-02-2019
12
0
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The objectives of the present study were to determine the effects of essential oil from Turkish oregano (Origanum onites L.) and its 2 major phenolic components, carvacrol and thymol, on cell viability, and to investigate their cytoprotective (antioxidant) effects against hydrogen peroxide-induced cytotoxicity and membrane damage in hepatoma G2 (Hep G2) cells.
8p
vivant2711
01-02-2019
32
2
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Cycloart-23Z-ene-3-25-diol was isolated from the leaves of Aglaia gigantea by bioassayguided fractionation. This compound showed very good cytotoxicity against human hepatoma (Hep-G2) and KB cells. In oder to investigate the relationship between biological activity and structure of the derivatives of cycloart-23Z-ene-3-25-diol, we carried out synthesis of several new derivatives and examined their biological activities.
5p
uocvong04
24-09-2015
42
3
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Intravenous iron, used for the treatment of anemia in chronic renal failure andother diseases, represents a possible source of free iron in tissue cells, particularly in the liver. In this study we examined the effect of different sources of intravenous iron (IVI) on the labile iron pool (LIP) which represents the nonferritin-bound, redox-active iron that is implicated in oxidative stress and cell injury. Furthermore, we examined the role of the LIP for the synthesis of ferritin.
8p
tumor12
20-04-2013
44
2
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The therapeutic effect of iron (Fe) chelators on the poten-tially toxic plasma pool of nontransferrin-bound iron (NTBI), often present in Fe overload diseases and in some cancer patients during chemotherapy, is of considerable interest. In the present investigation, several multidentate pyridinones were synthesized and compared with their bidentateanalogue, deferiprone
10p
fptmusic
16-04-2013
26
2
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Iron overload in the liver may occur in clinical conditions such as hemo-chromatosis and nonalcoholic steatohepatitis, and may lead to the deterior-ation of the normal liver architecture by mechanisms not well understood. Although a relationship between the expression of ICAM-1, and classical major histocompatibility complex (MHC) class I molecules, and iron over-load has been reported, no relationship has been identified between iron overload and the expression of unconventional MHC class I molecules....
14p
awards
05-04-2013
29
2
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Control analysis of the glycolytic flux was carried out in two fast-growth tumor cell types of human and rodent origin (HeLa and AS-30D, respect-ively). Determination of the maximal velocity (Vmax) of the 10 glycolytic enzymes from hexokinase to lactate dehydrogenase revealed that hexokin-ase (153–306 times) and phosphfructokinase-1 (PFK-1) (22–56 times) had higher over-expression in rat AS-30D hepatoma cells than in normal freshly isolated rat hepatocytes.
14p
inspiron33
26-03-2013
43
3
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Physalis philadelphicaLam, commonly known as a tomatillo, is a staple of the Mesoamerican cuisine. In our laboratory, an ethyl acetate-soluble extract and four withanolides [ixocarpalactone A (IxoA), ixocarpalac-tone B, philadelphicalactone B, and withaphysacarpin] were isolated. Stud-ies conducted on Hepa-1c1c7 hepatoma cells revealed that withanolides were potent inducers of quinone reductase, suggesting possible cancer chemo-protective activity.
10p
inspiron33
23-03-2013
35
2
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