Heterocyclic
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In the further research and synthesis of hybrid molecules which exhibit highly biological activities, the synthesis of triazole-fused bicyclic heterocycles bearing the benzofuran has been undertaken. A facile, convenient and good yielding synthesis of novel benzofuran-bearing 1,2,4-trazole derivatives were described.
6p viprimi 16-12-2024 0 0 Download
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Goals of the study: Synthesis of new organic compounds (target) containing imidazole-5-one heterocycle; thiazolidine-2,4-dione heterocycle or 1,3,4-oxadiazoline heterocycle with different substituents in experimental conditions of Vietnam. Study on the properties, structures and biological activities of these compounds to contribute to the studies of both theory and application of heterocyclic compounds.
27p prisonbreak123 21-05-2021 25 4 Download
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A fast and facile one-pot procedure for the preparation of symmetric 5-Aryloyl-1,9-dimethyl-5,9-dihydro-2H-pyrano[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H)-tetraone derivatives by two-component reaction of N-methylbarbituric acid and arylglyoxalmonohydrates catalyzed by DABCO in ethanol at 50 ºC is described.
14p tocectocec 25-05-2020 13 1 Download
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Two heterocyclic oximes (E)-N-hydroxy-1-(pyridin-2-yl)methanimine (Hp2ylm) and (E)-N-hydroxy-1-(pyridin-3-yl)methanimine (Hp3ylm) were synthesized from pyridine-2-carbaldehyde and pyridine-3-carbaldehyde, respectively.
12p tocectocec 25-05-2020 11 2 Download
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The presence of heterocyclic moiety in diverse compounds, strongly indicative of the desired effect on physiological activity, and it reflects on efforts to find useful synthetic drugs.
12p tocectocec 25-05-2020 19 2 Download
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An environmentally benign aqueous protocol for the synthesis of novel 2-((5-(4-methoxybenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)amino)substituted acid by using potassium carbonate as a base has been achieved.
14p tocectocec 25-05-2020 10 0 Download
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Synthesis and characterization of some derivatives of 1,3-Diisopropyl-4,5-dimethylimidazol-2-ylidene
N-Heterocyclic carbenes are widely used in organic reactions and coordination chemistry. In the present study, 2,3-dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (1) is reacted with diphenyl disulfide, methyl phenyl disulfide, and bis(methylsulfonyl)methane to yield target compounds 5, 6, and 7 respectively.
6p tocectocec 25-05-2020 8 0 Download
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The mechanism of corrosion inhibition was explored and supplemented by adsorption and surface morphological studies. Quantum mechanical investigations on corrosion behaviour of compounds were also conducted and satisfying correlation was noticed between the results of corrosion measurement methods and quantum mechanical evaluations.
12p tocectocec 25-05-2020 20 2 Download
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The corrosion inhibition efficiencies of two novel Schiff bases, namely (E)-3-[thiophen-2-lmethyleneamino]benzoic acid (T2YMABA) and (E)-4-(5-[(2-phenylhydrazono) methyl]thiophen-2-yl)benzoic acid (PHMT2YBA) on mild steel (MS) in 1.0M HCl solution has been investigated and compared using electrochemical impedance spectroscopy and potentiodynamic polarization analysis.
10p tocectocec 25-05-2020 21 2 Download
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A molecular mechanism of the [3+2] cycloaddition has been explored using various DFT theoretical levels.
8p tocectocec 25-05-2020 7 1 Download
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An ecofriendly methods for the synthesis of medicinally important class of heterocyclic scaffold, pyrazole 4-carbonitrile derivatives by one pot three component reaction of malononitrile, phenyl hydrazine and aromatic aldehyde has been achieved at room temperature.
8p tocectocec 25-05-2020 9 0 Download
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Reaction of methyl 2-aryl-5-(chlorosulfonyl)-1,3-oxazole-4-carboxylates with 1H-pyrazol-5-amines and 1H-1,2,4-triazol-5-amines proceeds with the participation of endocyclic aminoazole nitrogen atoms to yield products containing a primary amino group.
10p tocectocec 25-05-2020 10 0 Download
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The P450morsystem fromMycobacteriumsp. strain HE5, supposed to cata-lyse the hydroxylation of different N-heterocycles, is composed of three components: ferredoxin reductase (FdRmor), Fe3S4 ferredoxin (Fd mor) and cytochrome P450 (P450mor). In this study, we purified Fdmorand P450mor as recombinant proteins as well as FdRmor, which has been isolated previ-ously.
12p awards 05-04-2013 38 3 Download
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The amino acid residue tryptophan 27 of 6,7-dimethyl-8-ribityllumazine synthase of the yeastSchizosaccharomyces pombewas replacedby tyrosine. The structures of theW27Y mutant protein in complex with riboflavin, the substrate analogue 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidin-edione, and the product analogue 6-carboxyethyl-7-oxo-8-ribityllumazine,weredeterminedbyX-raycrystallography at resolutions of 2.7–2.8 A ˚ .
7p awards 05-04-2013 45 6 Download
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The cobalamin–dependent cytosolic enzyme, methionine synthase (EC.2.1.1.13), catalyzes the remethylation of homocysteine to methionine using 5-methyltetrahydrofolate as the methyl donor. The products of this remethylation – methionine and tetrahydrofolate – participate in the active methionine and folate pathways.
13p inspiron33 23-03-2013 36 3 Download
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Nghiên cứu của Đại học Kansas (Mỹ) cho thấy, các loại nước sốt với các thành phần gia vị như cỏ xạ hương (thyme), hương thảo (rosemary), tỏi… có thể làm giảm 60 – 80% lượng heterocyclic amine (HCAs) gây ung thư trong các món nướng. Tuy nhiên, không nên ướp nước sốt vào nguyên liệu quá lâu trước khi nướng, vì như vậy có thể giảm thành phần các chất chống oxy hóa có lợi trong nước sốt. Tốt nhất là ướp trước vài tiếng, sau đó khi nướng thực phẩm gần chín thì phủ thêm một chút nước...
4p nkt_bibo14 16-11-2011 52 5 Download
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1/ CÁC THUỐC CHỐNG TRẦM CẢM ĐƯỢC XẾP LOẠI NHƯ THẾ NÀO VÀ CƠ CHẾ TÁC DỤNG CHÍNH CỦA CHÚNG ? Các thuốc chống trầm cảm có thể được chia thành 3 loại lớn, gồm có các thuốc chống trầm cảm 3 vòng (tricyclic antidepressants = TCAs ), monoamine oxidase inhibitors (MAOIs) và các thuốc mới hơn được gọi là các thuốc chống trầm cảm không điển hình (atypicals), dị vòng (heterocyclic) hoặc thế hệ thứ hai (second-generation). ...
2p tuoanh04 07-07-2011 81 4 Download
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Các thuốc chống trầm cảm có thể được chia thành 3 loại lớn, gồm có các thuốc chống trầm cảm 3 vòng (tricyclic antidepressants = TCAs ), monoamine oxidase inhibitors (MAOIs) và các thuốc mới hơn được gọi là các thuốc chống trầm cảm không điển hình (atypicals), dị vòng (heterocyclic) hoặc thế hệ thứ hai (second-generation). Các thuốc chống trầm cảm 3 vòng (TCAs) được xếp loại thành amines đệ nhị hoac đệ tam và chứa một chuỗi bên với một số thay đổi nhóm methyl. ...
14p thiuyen111 11-04-2011 144 10 Download
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Nucleotide là một hợp chất hóa học gồm có 3 phần chính: một nhóm , nhóm đường, và một hay nhiều nhóm phosphate. Các nucleotide phổ biến nhất là dẫn xuất của purine hoặcpyrimidine, và đường ở dạng pentose (đường chứa 5 cacbon) deoxyribose hay ribose.
8p heoxinhkute 29-07-2010 118 14 Download