High genetic diversity
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The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant Gram-negative and Gram-positive pathogens.
13p vibransone 28-03-2024 3 2 Download
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We highlight the current lack of representation of the Middle East from large genomic studies and emphasize the expected high impact of cataloging its variation. We discuss the limiting factors and possible solutions to generating and accessing research and clinical sequencing data from this part of the world.
4p vibransone 28-03-2024 3 2 Download
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Part 2 book "Genomic management of animal genetic diversity" includes content: Tracing domestication and selection in animal genomes, management of genetic diversity including genomic selection in small in vivo populations, gog breeds - towards genomic management of populations with a high incidence of genetic defects.
124p oursky05 20-09-2023 3 2 Download
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Bovine leukocyte antigens (BoLAs) are used extensively as markers of disease and immunological traits in cattle. However, until now, characterization of BoLA gene polymorphisms in Zebu breeds using high resolution typing methods has been poor.
13p vinarcissa 21-03-2023 3 1 Download
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High-density single nucleotide polymorphisms (SNPs) are the most abundant and robust form of genetic variants and hence make highly favorable markers to determine the genetic diversity and relationship, enhancing the selection of breeding materials and the discovery of novel genes associated with economically important traits.
13p vinarcissa 21-03-2023 2 1 Download
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The existence of moderate to high levels of linkage disequilibrium (LD) between genetic markers and quantitative trait loci (QTL) affecting traits of interest is fundamental for the success of genome-wide association (GWAS) and genomic selection (GS) studies. Knowledge about the extent and the pattern of LD in livestock populations is essential to determine the density of single nucleotide polymorphisms (SNP) required for accurate GWAS and GS.
12p vinarcissa 21-03-2023 7 1 Download
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Diversity in crops is fundamental for plant breeding efforts. An accurate assessment of genetic diversity, using molecular markers, such as single nucleotide polymorphism (SNP), must be able to reveal the structure of the population under study
12p vinarcissa 21-03-2023 8 1 Download
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The aim of this research was to establish the scientific basis for the implementation of genomic selection in a composite Terminal sheep breeding scheme by providing consolidated linkage disequilibrium (LD) measures across SNP markers, estimating consistency of gametic phase between breed-groups, and assessing genetic diversity measures, such as effective population size (Ne), and population structure parameters, using a large number of animals (n = 14,845) genotyped with a high density SNP chip (606,006 markers).
11p vinarcissa 21-03-2023 4 1 Download
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Cymbidium is a genus of 68 species in the orchid family, with extremely high ornamental value. Marker-assisted selection has proven to be an effective strategy in accelerating plant breeding for many plant species.
14p vinarcissa 21-03-2023 3 1 Download
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Wild boar, Sus scrofa, is an extant wild ancestor of the domestic pig as an agro-economically important mammal. Wild boar has a worldwide distribution with its geographic origin in Southeast Asia, but genetic diversity and genetic structure of wild boar in East Asia are poorly understood.
10p vinarcissa 21-03-2023 2 1 Download
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Cold stress is an important factor limiting rice yield in many areas of high latitude and altitude. Considerable efforts have been taken to genetically dissect cold tolerance (CT) in rice using DNA markers.
14p vinarcissa 21-03-2023 3 1 Download
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Teleost fish present a high diversity of sex determination systems, with possible frequent evolutionary turnover of sex chromosomes and sex-determining genes. In order to identify genes involved in male sex determination and differentiation in the platyfish Xiphophorus maculatus, bacterial artificial chromosome contigs from the sex-determining region differentiating the Y from the X chromosome have been assembled and analyzed.
13p vinarcissa 21-03-2023 1 1 Download
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Levels of inbreeding in cattle populations have increased in the past due to the use of a limited number of bulls for artificial insemination. High levels of inbreeding lead to reduced genetic diversity and inbreeding depression. Various estimators based on different sources, e.g., pedigree or genomic data, have been used to estimate inbreeding coefficients in cattle populations.
11p vinarcissa 21-03-2023 6 1 Download
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Enset (Ensete ventricosum (Welw.) Cheesman; Musaceae) is a multipurpose drought-tolerant food security crop with high conservation and improvement concern in Ethiopia, where it supplements the human calorie requirements of around 20 million people.
16p vinarcissa 21-03-2023 4 1 Download
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Variation in human skin pigmentation evolved in response to the selective pressure of ultra-violet radiation (UVR). Selection to maintain darker skin in high UVR environments is expected to constrain pigmentation phenotype and variation in pigmentation loci.
15p vinarcissa 21-03-2023 4 1 Download
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Genome variability of host genome and cancer cells play critical role in diversity of response to existing therapies and overall success in treating oncological diseases. In chronic myeloid leukemia targeted therapy with tyrosine kinase inhibitors demonstrates high efficacy in most of the patients.
6p vinarcissa 21-03-2023 4 1 Download
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In this study, we aimed to understand the genetic structure of 440 individual wild cherries sampled from 22 different populations in Turkey using 10 SSR molecular markers. With the molecular variance analysis, we found that the genetic diversity within the population is approximately 88.5% and the genetic diversity among the populations is approximately 9.8%. Thus, wild cherry genetic diversity within populations is high whereas it is moderate between tested populations (FST values 0.02-0.16).
12p lyhuyenthu 31-01-2023 6 2 Download
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Strawberry (Fragaria x ananassa Duch.) is a favorite fruit of high economic value due to its good taste and high nutrition ingredients. Strawberry is a fruit grown around the world that has distinct genetic structures and indicates diverse levels of precision to different environmental circumstances. Plants respond differently to diverse physiological processes, organizing of biological events, control of hormones, different individuals of the same species, and internal and external factors in developmental stages.
16p lyhuyenthu 31-01-2023 9 2 Download
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The advance of high-throughput technologies has made it cost-effective to collect diverse types of omic data in large-scale clinical and biological studies. While the collection of the vast amounts of multi-level omic data from these studies provides a great opportunity for genetic research, the high dimensionality of omic data and complex relationships among multi-level omic data bring tremendous analytic challenges.
12p vihagrid 30-01-2023 10 3 Download
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Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations.
17p vihagrid 30-01-2023 5 3 Download