High heterogeneity
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Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR≥95%) from RT is associated with improved patient outcome.
16p vishanshan 27-06-2024 1 1 Download
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The presence of heterogeneity is a significant attribute within the context of ovarian cancer. This study aimed to assess the predictive accuracy of models utilizing quantitative 18F-FDG PET/CT derived inter-tumor heterogeneity metrics in determining progression-free survival (PFS) and overall survival (OS) in patients diagnosed with high-grade serous ovarian cancer (HGSOC).
13p vishanshan 27-06-2024 2 1 Download
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Prognosis prediction for pancreatic cancer has always been difficult in clinical practice because of its high heterogeneity and mortality. The aim of the study was to assess the value of prognostic immune-inflammatorynutritional (PIIN) score on overall survival (OS) in postoperative patients with pancreatic cancer and to develop a nomogram incorporating PIIN score.
10p vikoch 27-06-2024 1 1 Download
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Self-assembled functional nanomaterials with electromagnetic (EM) hot spots and chemical (CM) enhancement have been recognized as a key in surface-enhanced Raman scattering (SERS) analysis. Herein, a dual-hybrid plasmonic coupling SERS sensor composed of rutile TiO2 nanorod arrays (r-TNRs), Au nanospheres (AuNSs), and Ag nanocubes (AgNCs) has been designed to achieve ultrasensitive detection and obtain unique molecular fingerprints.
13p visergeyne 18-06-2024 1 0 Download
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Associative Classification is an interesting approach in data mining to create more accurate and easily interpretable predictive systems. This approach is often built on both association rule mining and classification techniques, to find a set of rules called association rules for classification (CAR) of label attributes.
7p viohoyo 25-04-2024 2 2 Download
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Querying cancer genomes at single-cell resolution is expected to provide a powerful framework to understand in detail the dynamics of cancer evolution. However, given the high costs currently associated with single-cell sequencing, together with the inevitable technical noise arising from single-cell genome amplification, cost-effective strategies that maximize the quality of single-cell data are critically needed.
11p vibransone 28-03-2024 2 1 Download
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Large-sequencing cancer genome projects have shown that tumors have thousands of molecular alterations and their frequency is highly heterogeneous. In such scenarios, physicians and oncologists routinely face lists of cancer genomic alterations where only a minority of them are relevant biomarkers to drive clinical decisionmaking.
11p vibransone 28-03-2024 4 2 Download
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Dietary glycans, widely used as food ingredients and not directly digested by humans, are of intense interest for their beneficial roles in human health through shaping the microbiome. Characterizing the consistency and temporal responses of the gut microbiome to glycans is critical for rationally developing and deploying these compounds as therapeutics.
16p vibransone 28-03-2024 6 2 Download
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Cryopreservation of human cancers conserves tumour heterogeneity for singlecell multi-omics analysis
High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing.
17p vibransone 28-03-2024 1 1 Download
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High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate characterisation of this heterogeneity, but the lack of strong prognostic or predictive correlations with these subtypes currently hinders their clinical implementation.
30p vibransone 28-03-2024 6 2 Download
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Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous (LGSOC), endometrioid (ENOC), clear cell (CCOC) and mucinous (MOC).
19p vibransone 28-03-2024 3 2 Download
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Multiple sclerosis is a chronic neuroinfammatory disease with a highly heterogeneous disease course. Preventing lasting disability requires early identification of persons at risk and novel approaches towards patient stratification for personalized treatment decisions. In this comment, we discuss the importance of large datasets of real-world cohorts in order to address this unmet need.
3p viellison 28-03-2024 4 2 Download
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ung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance and failure. Single-cell RNA sequencing (scRNA-seq) has been widely used to dissect the cellular composition and characterize the molecular properties of cancer cells and their tumor microenvironment in lung cancer.
18p viellison 28-03-2024 4 2 Download
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Lung adenocarcinoma, the most common type of lung cancer, has a high level of morphologic heterogeneity and is composed of tumor cells of multiple histological subtypes. It has been reported that immune cell infiltration significantly impacts clinical outcomes of patients with lung adenocarcinoma.
15p viellison 28-03-2024 5 2 Download
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Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen dep‑ rivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do not include evolution as an essential feature.
15p vicwell 29-02-2024 2 2 Download
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Biallelic variants in OGDHL, encoding part of the α-ketoglutarate dehydrogenase complex, have been associated with highly heterogeneous neurological and neurodevelopmental disorders. However, the validity of this association remains to be confirmed.
24p vicwell 29-02-2024 1 1 Download
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Neoadjuvant chemotherapy (NAC) has become a standard treatment strategy for breast cancer (BC). However, owing to the high heterogeneity of these tumors, it is unclear which patient population most likely benefit from NAC. Multi-omics ofer an improved approach to uncovering genomic and transcriptomic changes before and after NAC in BC and to identifying molecular features associated with NAC sensitivity.
19p vicwell 29-02-2024 4 2 Download
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Type 2 diabetes (T2D) is a heterogeneous and polygenic disease. Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants to partition the heterogeneity of T2D, in order to stratify patient risk and gain mechanistic insight. We expanded on these approaches by performing colocalization across GWAS traits while assessing the causality and directionality of genetic associations.
15p vicwell 29-02-2024 3 1 Download
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The third generation (3G) of mobile networks introduces wide spectrum and high data rates as well as variety of circuit-switched and packet-based services. It provides IP connectivity besides the circuit switching. Future generation mobile systems are expected to include heterogeneous access technologies, such as wireless LAN and 3G, as well as end-to-end IP connectivity (i.e., an all-IP network). The diversity of traffic services and access technologies creates new possibilities for both operators and users. On the other hand, it raises new traffic and design issues.
385p longtimenosee03 22-02-2024 6 2 Download
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Ebook "NMR-bioassay guided isolation of the natural 20S proteasome inhibitors from photorhabdus luminescens: A novel NMR-tool for natural product detection" describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts.
84p nhanphanguyet 28-01-2024 2 2 Download