High throughput drug screening

This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development.

339p vimeyers 29-05-2024 4 2   Download

Ebook "Targeting protein-protein interactions by small molecules" comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design.

332p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

203p tracanhphuonghoa1007 22-04-2024 3 2   Download

Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.

327p tracanhphuonghoa1007 22-04-2024 3 3   Download

Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

248p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "Prokaryotic systems biology (Advances in experimental medicine and biology, Volume 883)" focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species.

326p duongthandue0501 28-02-2024 3 1   Download

Ebook "Tactics in contemporary drug design" covers all relevant aspects of drug research, e.g.

400p manmanthanhla0201 26-02-2024 2 1   Download

Ebook "Yellow biotechnology II: Insect biotechnology in plant protection and industry" has been introduced an alternative term for insect biotechnology, which is an emerging field in applied entomology. As a complement to Part I, which focuses on the use of insects in drug discovery and preclinical research, Part II considers the applications of insect biotechnology in industrial and food biotechnology, and in modern approaches that allow the sustainable protection of plants.

215p nhanphanguyet 28-01-2024 5 2   Download

Ebook "Carbohydrates as drugs" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations,...

242p nhanphanguyet 28-01-2024 5 2   Download

Ebook "The blood brain barrier (BBB)" covers all relevant aspects of drug research, e.g.

169p nhanphanguyet 28-01-2024 5 2   Download

High-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most phenotypic screening platforms used in the field of oncology are based solely on cancer cell populations and do not allow for the identification of immunomodulatory agents.

10p vischultz 20-10-2023 3 1   Download

One of the key elements in the early stages of drug discovery is finding good hits to develop lead compounds. Although HTS has been used as a standardized technology for hit finding, it still bears some challenging drawbacks: expensive and low-quality data. Aiming at the same goal as HTS, virtual screening (VS) has been developed to reduce cost and increase efficiency. Recent studies show that VS can deliver numerous quality hits and a few of them even reach clinical trials.

9p nguaconbaynhay12 01-06-2021 16 1   Download

Drug discovery and development has been aided by high throughput screening methods that detect compound effects on a single target. However, when using focused initial screening, undesirable secondary effects are often detected late in the development process after significant investment has been made.

11p vikentucky2711 26-11-2020 8 0   Download

Cytotoxicity assays have been used by researchers to screen for cytotoxicity in compound libraries. Researchers can either look for cytotoxic compounds or screen “hits” from initial high-throughput drug screens for unwanted cytotoxic effects before investing in their development as a pharmaceutical.

7p vioklahoma2711 19-11-2020 6 1   Download

Drug discovery is the process through which potential new medicines are identified. High-throughput screening and computer-aided drug discovery/design are the two main drug discovery methods for now, which have successfully discovered a series of drugs.

11p viconnecticut2711 28-10-2020 17 0   Download

Drug combinations have the potential to improve efficacy while limiting toxicity. To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points.

15p vicoachella2711 27-10-2020 17 0   Download

Cardiotoxicity, characterized by severe cardiac dysfunction, is a major problem in patients treated with different classes of anticancer drugs. Development of predictable human-based models and assays for drug screening are crucial for preventing potential drug-induced adverse effects. Current animal in vivo models and cell lines are not always adequate to represent human biology.

12p vicolorado2711 22-10-2020 21 0   Download

Aggressive metastatic breast cancer cells seemingly evade surgical resection and current therapies, leading to colonization in distant organs and tissues and poor patient prognosis. Therefore, high-throughput in vitro tools allowing rapid, accurate, and novel anti-metastatic drug screening are grossly overdue.

16p vilisa271 22-09-2020 12 1   Download

The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive cancers display de novo resistance to tamoxifen, and acquired resistance evolves in 40 % of patients who initially respond.

17p vinaypyidaw2711 26-08-2020 10 0   Download

Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synthetically lethal in β-catenin-activated cancer cells would provide new targets for therapeutic drug design.

12p vinaypyidaw2711 26-08-2020 10 2   Download