Highly complex task

A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.

15p vibransone 28-03-2024 3 2   Download

Understanding the relation between chemical characteristics and properties of synthetic polymers is one of the challenges faced by analytical chemists in industry. This is a complex task, as polymers are not synthesized as single molecule, but are populations of chemically similar compounds with distributions over several properties.

6p viginny 23-12-2022 10 3   Download

Breaking bad news (BBN) to patients and their relatives is a complex and stressful task. The ideal structure, training methods and assessment instruments best used to teach and assess BBN for anesthesiology residents remain unclear. The purpose of this study is to evaluate the effectiveness of an education intervention for BBN based on immersive experiences with a high fidelity simulator and role-play with standardized patients (SPs).

6p viottohahn 30-03-2022 11 1   Download

Reconstructing genomic segments from metagenomics data is a highly complex task. In addition to general challenges, such as repeats and sequencing errors, metagenomic assembly needs to tolerate the uneven depth of coverage among organisms in a community and differences between nearly identical strains.

14p vielonmusk 30-01-2022 13 0   Download

High-throughput sequencing (HTS) technologies are increasingly applied to analyse complex microbial ecosystems by mRNA sequencing of whole communities, also known as metatranscriptome sequencing. This approach is at the moment largely limited to prokaryotic communities and communities of few eukaryotic species with sequenced genomes. For eukaryotes the analysis is hindered mainly by a low and fragmented coverage of the reference databases to infer the community composition, but also by lack of automated workflows for the task.

17p vilarryellison 29-10-2021 11 1   Download

A common class of biomedical analysis is to explore expression data from high throughput experiments for the purpose of uncovering functional relationships that can lead to a hypothesis about mechanisms of a disease. We call this analysis expression driven, −omics hypothesizing.

12p vikentucky2711 26-11-2020 7 0   Download

Metabolomics datasets are often high-dimensional though only a limited number of variables are expected to be informative given a specific research question. The important task of selecting informative variables can therefore become complex. In this paper we look at discriminating between two groups.

12p vioklahoma2711 19-11-2020 12 4   Download

Interpreting non-targeted metabolomics data remains a challenging task. Signals from non-targeted metabolomics studies stem from a combination of biological causes, complex interactions between them and experimental bias/noise.

14p vioklahoma2711 19-11-2020 6 1   Download

Understanding protein structure and dynamics is essential for understanding their function. This is a challenging task due to the high complexity of the conformational landscapes of proteins and their rugged energy levels. In particular, it is important to detect highly populated regions which could correspond to intermediate structures or local minima.

9p viconnecticut2711 29-10-2020 13 1   Download

Microarray datasets consist of complex and high-dimensional samples and genes, and generally the number of samples is much smaller than the number of genes. Due to this data imbalance, gene selection is a demanding task for microarray expression data analysis.

15p vicolorado2711 23-10-2020 9 1   Download

NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘)i are essential for activating NS3 upon NS3/4A protease complex formation. This study aims to design new specific allosteric NS3/4A protease inhibitors by mutating Val-23‘, Ile-25‘, and Ile-29‘ into bulkier amino acids. Pep-15, a synthetic peptide, showed higher binding affinity towards HCV-NS3 subtype-4 than native NS4A. The Kd of Pep-15 (80.0 ± 8.0 nM) was twice as high as that of native NS4A (169 ± 37 nM).

9p partimesinhvien 08-05-2020 15 1   Download

The problem of determining the optimum exploitation life of machinery, namely, the optimum time for machinery and equipment replacement, represents a complex and highly responsible engineering task. Taking into consideration the situation prevailing at coal pit mines in Serbia, the tasks of this rank are very complex and difficult. To make a decision on the replacement of capital equipment and machinery, such as bucket wheel excavators within the mentioned systems, implies a management task of utmost responsibility.

13p vinguyentuongdanh 19-12-2018 16 1   Download

For these reasons, mobility systems on mobile robots can be both sim- pler and more complex than those found in automobiles. For example, the Ackerman steering system in automobiles is not actually suited for high mobility. It feels right to a human, and it is well suited to higher speed travel, but a robot doesn’t care about feeling right, not yet, at least! The best mobility system for a robot to have is one that effectively accomplishes the required task, without regard to how well a human could use it....

25p loixinloi 08-05-2013 38 2   Download

Patent translation is a complex problem due to the highly specialized technical vocabulary and the peculiar textual structure of patent documents. In this paper we analyze patents along the orthogonal dimensions of topic and textual structure. We view different patent classes and different patent text sections such as title, abstract, and claims, as separate translation tasks, and investigate the influence of such tasks on machine translation performance.

11p bunthai_1 06-05-2013 44 2   Download

These educational requirements reflect a need for highly skilled workers who can perform complex, ever-changing tasks. Economists have classified the intensity of five types of tasks across occupations using the Dictionary of Occupational Titles (DOT).

19p trinhcaidat 19-04-2013 30 4   Download

People who administer the operation of an Oracle database system, known as database administrators (DBAs), are responsible for creating Oracle databases, ensuring their smooth operation, and monitoring their use. In addition to the many alerts and advisors Oracle provides, Oracle also offers the following features: Self-Managing Database Oracle Database provides a high degree of self-management - automating routine DBA tasks and reducing complexity of space, memory, and resource administration.

348p nhacsihuytuan 13-04-2013 44 3   Download

Building an accurate Named Entity Recognition (NER) system for languages with complex morphology is a challenging task. In this paper, we present research that explores the feature space using both gold and bootstrapped noisy features to build an improved highly accurate Arabic NER system.

5p hongdo_1 12-04-2013 59 4   Download

Convolution kernels support the modeling of complex syntactic information in machinelearning tasks. However, such models are highly sensitive to the type and size of syntactic structure used. It is therefore an important challenge to automatically identify high impact sub-structures relevant to a given task.

6p nghetay_1 07-04-2013 64 2   Download

Carbon Monoxide is toxic to humans. Even healthy people can be affected by carbon monoxide. People who breathe high levels of CO can develop vision problems, redued ability to work or learn, or have difficulty performing complex tasks. People who have heart disease may cause chest pains or other more serious cardiovascular effects. The problem with air pollution is that it looks to be increasing in toxicity rather than being solved or reduced. More and more people are driving automobiles or trucks. And the Earth’s growing population is requiring more electricity to...

14p tainhacmienphi 19-02-2013 54 4   Download

Program design of small programs is relatively simple and involves the analysis of the problem, collection of inputs, using the programming constructs within languages, devising or using established procedures and algorithms, providing data for output devices and solutions to the problem as applicable. As problems become larger and more complex, features such as subprograms, modules, formal documentation, and new paradigms such as object-oriented programming are encountered. Large programs involving thousands of line of code and more require formal software methodologies.

50p khangoc2399 21-09-2012 52 5   Download