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Histone lysine methylation
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Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities. Merkel cell tumors display with neuroendocrine features and Merkel cell polyomavirus (MCPyV) infection in the majority (80%) of patients. Although loss of histone H3 lysine 27 trimethylation (H3K27me3) has been shown during MCC tumorigenesis, epigenetic dysregulation has largely been overlooked.
17p
vibransone
28-03-2024
1
1
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Using metaphase spreads from human lymphoblastoid cell lines, we previously showed how immunofluorescence microscopy could define the distribution of histone modifications across metaphase chromosomes. We showed that different histone modifications gave consistent and clearly defined immunofluorescent banding patterns.
7p
vinarcissa
21-03-2023
2
1
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Global warming severely affects flowering time and reproductive success of plants. Alternative splicing of pre-messenger RNA (mRNA) is an important mechanism underlying ambient temperature-controlled responses in plants, yet its regulation is poorly understood.
12p
vialfrednobel
29-01-2022
8
0
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Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-activated genes in Neurospora crassa (Neurospora), including frequency (frq) and vivid (vvd).
19p
visilicon2711
20-08-2021
7
1
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Histone methylation mainly occurs on the lysine residues and plays a crucial role during flowering and stress responses of plants, through changing the methylation status or ratio of lysine residues.
16p
visilicon2711
20-08-2021
8
0
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Histone lysine methylation plays an important role in plant development and stress responses by activating or repressing gene expression. Histone lysine methylation is catalyzed by a class of SET-domain group proteins (SDGs).
17p
vilichoo2711
23-06-2021
15
2
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KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; however, they are inactive outside of a multi-protein complex that requires WDR5.
13p
vibaku2711
22-07-2020
8
1
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Dendrobium catenatum, as a precious Chinese herbal medicine, is an epiphytic orchid plant, which grows on the trunks and cliffs and often faces up to diverse environmental stresses.
19p
viharuno2711
21-04-2020
13
1
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Lung cancer is one of the most common malignant tumors. Histone methylation was reported to regulate the expression of a variety of genes in cancer. However, comprehensive understanding of the expression profiles of histone methyltransferases and demethylases in lung cancer is still lacking.
9p
vinasaki2711
12-11-2019
9
0
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Histones are modified post-translationally, e.g. by methylation of lysine and arginine residues, and by phosphorylation of serine residues. These modifications regulate processes such as gene expression, DNA repair, and mitosis and meiosis. Recently, evidence has been provided that histones are also modified by covalent binding of the vitamin biotin.
11p
fptmusic
11-04-2013
38
1
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Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. There are several pathways, including histone tail mod-ifications, histone variant incorporation, nucleosome remodelling, DNA methylation and noncoding RNAs that together all contribute to the dynamic ‘make-up’ of chromatin under distinct developmental options.
15p
inspiron33
25-03-2013
36
2
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Lysine-specific demethylase 1 (LSD1) is an enzyme that removes methyl groups from mono- and dimethylated Lys4 of histone H3, a post-transla-tional modification associated with gene activation. Human LSD1 was the first histone demethylase to be discovered and this enzymatic activity is conserved among eukaryotes.
9p
vinaphone15
25-02-2013
30
2
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Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human
The fourth lysine of histone H3 is post-translationally modified by a methyl group via the action of histone methyltransferase, and such a covalent modification is associated with transcriptionally active and⁄or repressed chromatin states. Thus, histone H3 lysine 4 methylation has a crucial role in maintaining normal cellular functions.
17p
mobifone23
21-01-2013
36
2
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Epigenetic mechanisms, such as histone modifications, control eukaryotic development beyond DNA-stored information. Intrigu-ingly, there is an under-representation of repressive marks in quies-cent (resting) cells, stem cells and regenerating cells, but a selective accumulation of aberrant histone lysine methylation profiles in aging, ‘‘stressed’’ and tumor cells, particularly for the H3K9, H3K27 and H4K20 methyl marks.
65p
cosis54
05-01-2013
50
3
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