HIV protease inhibitors
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Human immunodeficiency virus-1-associated neurocognitive disorder is a known complication in individuals treated with antiretroviral therapy. Cerebrospinal fluid escape, which is defined as discordant higher cerebrospinal fluid viremia than plasma, may occur in antiretroviral therapy-experienced individuals.
4p vigojek 02-02-2024 2 1 Download
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The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the management of HIV, may increase toxicities in patients undergoing chemoradiation.
17p vimahuateng 26-11-2021 10 1 Download
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In this work we created a simple dynamic model for HIV infection with three parameters: The concentration of HIV virus, the concentration of health and the infected T-cells. Using a ‘therapy starting moment’ and this dynamic model, we investigated the effectiveness of HIV drug treatment.
7p tamynhan9 02-12-2020 13 3 Download
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The correlations of genotypic and phenotypic tests with treatment, clinical history and the significance of mutations in viruses of HIV-infected patients are used to establish resistance mutations to protease inhibitors (PIs).
17p vikentucky2711 26-11-2020 5 0 Download
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Strategies to control HIV for improving the quality of patient lives have been aided by the Highly Active Anti-Retroviral Therapy (HAART), which consists of a cocktail of inhibitors targeting key viral enzymes.
10p vioklahoma2711 19-11-2020 13 0 Download
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Drug resistance in HIV treatment is still a worldwide problem. Predicting resistance to antiretrovirals (ARVs) before starting any treatment is important. Prediction accuracy is essential, as low-accuracy predictions increase the risk of prescribing sub-optimal drug regimens leading to patients developing resistance sooner.
7p viflorida2711 30-10-2020 8 1 Download
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Human immunodeficiency virus (HIV) is a retro virus known to be the primary aetiological agent of Acquired Immunodeficiency syndrome (AIDS). It is reported that about 39 million people globally are living with HIV. HIV infected patients are frequently present with elevated levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). This has been often attributed to the hepatic effects of Antiretroviral- Protease Inhibitor drugs (PI’s).
7p nguaconbaynhay6 23-06-2020 8 1 Download
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L-phenylalanine (L-Phe) is an essential amino acid for mammals and applications expand into human health and nutritional products. In this study, a system level engineering was conducted to enhance L-Phe biosynthesis in Escherichia coli.
12p vihamax2711 21-04-2020 12 1 Download
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S-Phenyl-L-cysteine is regarded as having potential applicability as an antiretroviral/protease inhibitor for human immunodeficiency virus (HIV). In the present study, optically active S-phenyl-L-cysteine was prepared in a highly efficient manner from inexpensive bromobenzene using tryptophan synthase through a chemoenzymatic method.
8p vihamax2711 21-04-2020 16 0 Download
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Pharmacokinetic interactions between rifampicin and protease inhibitors (PIs) complicate the management of HIV-associated tuberculosis. Rifabutin is an alternative rifamycin, for patients requiring PIs.
11p vienzym2711 03-04-2020 15 1 Download
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Tham khảo sách 'cleaner production opportunity assessment study in seka balikesir pulp and paper mill', kỹ thuật - công nghệ, hoá học - dầu khí phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
23p loixinloi 08-05-2013 46 4 Download
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This explicit step requires the program to seek explanations for unusually high or low outcomes on each indicator. The organization should establish a routine process for examining the findings from the latest outcome reports. For example, exhibit 11 compares outcomes for three family service units on one particular demographic characteristic. The two outlying values circled in the exhibit indicate unusual outcomes that a program manager will likely want to investigate.
155p dacotaikhoan 26-04-2013 42 4 Download
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Even though more than 200 three-dimensional structures of HIV-1 protease complexed to a variety of inhibitors are available in the Protein Data Bank; very few struc-tures of unliganded protein have been determined. We have recently solved structures of unliganded HIV-1 protease tethered dimer mutants to resolutions of 1.9 A˚ and 2.1 A ˚ , and have found that the flaps assume closed-flap conformation even in the absence of any bound lig-and.
9p tumor12 20-04-2013 20 1 Download
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The impact of a rise in oil prices differs significantly across countries, and depends upon factors such as the oil (and gas) intensity of output, the speed of reaction of the wage-price system, the role of expectations2, the response of the monetary authorities, the export exposure to oil producing markets and the speed at which oil revenues are recycled back into the global trading system. In terms of inflation, the negative effects of higher oil prices tend to be felt less acutely in the Euro Area than the US as the Euro Area is...
189p hoangphiyeah1tv 18-04-2013 50 5 Download
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Báo cáo khoa học: Optimization of P1–P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
HIV-1 protease is an important target for treatment of AIDS, and efficient drugs have been developed. However, the resistance and negative side effects of the current drugs has necessitated the development of new compounds with different binding patterns. In this study, nine C-terminally duplicated HIV-1 protease inhibitors were cocrystallised with the enzyme, the crystal structures analysed at 1.8–2.3 A˚ resolution, and the inhibitory activity of the compounds characterized inorder toevaluate the effects of the individual modifications. ...
13p fptmusic 16-04-2013 42 2 Download
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We’ve tried to write a book for a wide range of Oracle users, from the novice to the experienced user. To address this range of users, we’ve focused on the concepts and technology behind the Oracle database. Once you fully understand these facets of the product, you’ll be able to handle the particulars of virtually any type of Oracle database. Without this understanding, you may feel overburdened as you try to con- nect the dots of Oracle’s voluminous feature set and documentation.
46p nhacsihuytuan 13-04-2013 52 3 Download
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Survey participants completed a two‐page, English‐based questionnaire that focused on the number of surgical and non‐surgical procedures they performed in 2010. The International Society of Aesthetic Plastic Surgeons (ISAPS) issued an invitation to participate in the study to approximately 20,000 Plastic Surgeons whose contact information is housed in their proprietary database. In addition, a request was made that all National Societies encourage their members/constituents to take part in the survey.
18p giamdocamnhac 06-04-2013 33 2 Download
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HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such,HIV-1proteasehasbecomean important target for the treatment ofAIDS, and efficient drugs have beendeveloped. However, negative side effects and fast emerging resistance to the current drugs have necessitated the development of novel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....
9p awards 05-04-2013 31 1 Download
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The crystal structure of the complex between human immunodeficiency virus type 1 (HIV-1) protease and a peptidomimetic inhibitor of ethyleneamine type has been refined toRfactor of 0.178 with diffraction limit 2.5 A ˚ .The peptidomimetic inhibitor Boc-Phe-Y[CH2CH2 NH]-Phe-Glu-Phe-NH2 (denoted here as OE) contains the ethylene-amine replacement of the scissilepeptidebond. The inhibitor lacks the hydroxyl group which is believed to mimic tetra-hedral transition state of proteolytic reaction and thus is suspected to be necessary for good properties of peptido-mimetic HIV-1 protease inhibitors.
11p awards 05-04-2013 36 3 Download
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David Thomson was indeed correct when he said that McLaglen’s screen persona of imperial tough guy had actual “authentic grounding in personal experience.
11p hongphuocidol 03-04-2013 72 8 Download