HLA genotype

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Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer

The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive.

15p vibransone 28-03-2024 4 2 Download

Pervasiveness of HLA allele-specific expression loss across tumor types

Efficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated killing of cancer cells. According to recent reports, patient HLA-I genotypes can impact the efficacy of cancer immunotherapy, and the somatic loss of HLA-I heterozygosity has been established as a factor in immune evasion.

12p vicwell 29-02-2024 3 1 Download

Khảo sát genotype của kháng nguyên bạch cầu người lớp II ở bệnh nhân suy thận

Kháng nguyên bạch cầu người (HLA) là một dấu ấn sinh học dùng để chẩn đoán bệnh nhân suy thận mạn. Tuy nhiên, ở các nhóm người khác nhau sẽ có nhóm các alen HLA đặc hiệu khác nhau. Mục đích của nghiên cứu này là khảo sát tính đa hình của HLA lớp II ở bệnh nhân suy thận mạn khu vực miền Trung Việt Nam.

6p viplato 02-01-2024 6 2 Download
Allele and haplotype frequencies in patients with hematopoietic stemcell transplantation in National Children’s Hospital

HLA (Human Leukocyte Antigen) gene is located on chromosome 6’s short arm, including several loci. HLA genotyping is necessary for transplantation, especially in hematopoietic stem cell transplantation. A crosssectional study to determine the frequency of HLA-A, HLA-B, and HLA-DRB1 alleles of 122 patients admitted to the National Children’s Hospital for Hematopoietic stem cell transplantation from the year between 2010 and 2020.

8p vihawkeye 26-05-2023 7 4 Download
HLA genotyping by next-generation sequencing of complementary DNA

Genotyping of the human leucocyte antigen (HLA) is indispensable for various medical treatments. However, unambiguous genotyping is technically challenging due to high polymorphism of the corresponding genomic region. Next-generation sequencing is changing the landscape of genotyping. In addition to high throughput of data, its additional advantage is that DNA templates are derived from single molecules, which is a strong merit for the phasing problem.

12p vilarryellison 29-10-2021 10 0 Download
ALPHLARD: A Bayesian method for analyzing HLA genes from whole genome sequence data

Although human leukocyte antigen (HLA) genotyping based on amplicon, whole exome sequence (WES), and RNA sequence data has been achieved in recent years, accurate genotyping from whole genome sequence (WGS) data remains a challenge due to the low depth. Furthermore, there is no method to identify the sequences of unknown HLA types not registered in HLA databases.

11p vitzuyu2711 29-09-2021 10 1 Download
HLA-check: Evaluating HLA data from SNP information

The major histocompatibility complex (MHC) region of the human genome, and specifically the human leukocyte antigen (HLA) genes, play a major role in numerous human diseases. With the recent progress of sequencing methods (eg, Next-Generation Sequencing, NGS), the accurate genotyping of this region has become possible but remains relatively costly.

8p viflorida2711 30-10-2020 5 2 Download
HLAscan: Genotyping of the HLA region using next-generation sequencing data

Several recent studies showed that next-generation sequencing (NGS)-based human leukocyte antigen (HLA) typing is a feasible and promising technique for variant calling of highly polymorphic regions.

11p viflorida2711 30-10-2020 7 1 Download
Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

The adaptive immune response intrinsically depends on hypervariable human leukocyte antigen (HLA) genes. Concomitantly, correct HLA phenotyping is crucial for successful donor-patient matching in organ transplantation.

12p viconnecticut2711 28-10-2020 12 1 Download
HLA A*32 is associated to HIV acquisition while B*44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants

Human leukocyte antigen (HLA) molecules play a key role in the cellular immune system. They may be determinants of mother-to-child transmission which is the driving force in pediatric HIV infection.

7p virome2711 13-01-2020 11 0 Download
Báo cáo y học: "HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient ...

9p thulanh13 15-10-2011 52 1 Download
Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility...

6p thulanh11 11-10-2011 38 2 Download