Host immune function
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Ebook "The new paradigm of immunity to tuberculosis" illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed.
294p ladongphongthanh1008 22-04-2024 7 2 Download
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Basal cell carcinoma (BCC) of the skin is the most common form of human cancer, with more than 90% of tumours presenting with clear genetic activation of the Hedgehog pathway. However, polygenic risk factors affecting mechanisms such as DNA repair and cell cycle checkpoints or which modulate the tumour microenvironment or host immune system play significant roles in determining whether genetic mutations culminate in BCC development.
12p vibransone 28-03-2024 3 2 Download
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Ebook "Crossroads between innate and adaptive immunity IV (Advances in experimental medicine and biology, Volume 785)" presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.
144p duongthandue0501 28-02-2024 1 1 Download
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Nivolumab is an immune checkpoint inhibitor that blocks inhibitors of T-cell activation and blunts antitumor immunity and is used in the treatment of various cancers. However, immune checkpoint inhibitors have immune-related adverse effects on various organs due to promoting T-cell activity against host tissues by blocking inhibition of T-cell function.
5p vigojek 02-02-2024 3 1 Download
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Part 1 book "Current trends in the study of bacterial and viral fish and shrimp diseases" includes content: Bacterial diseases of fish — where do we, viruses of fish, innate immune recognition of pathogens, molecular mechanisms of interactions between, molecular mechanisms of host–pathogen interactions between vibrio anguillarum and fish, molecular characterization and pathogenicity of white spot syndrome virus, use of functional genomics to identify and characterize virulence factors of edwardsiella tarda, use of genomics and proteomics to study white spot syndrome virus.
245p oursky10 04-12-2023 3 2 Download
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Human immunodeficiency virus (HIV) and nutrition status of human are linked to HIV infection and poor nutrient intake can speed the disease progress. Both macro-and micronutrient deficiencies could impair host immune functions and promote viral replication and pathogenicity, thus potentially affecting the clinical course of HIV infection.
7p viisac 23-09-2023 3 1 Download
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The structural diversity of the lipopolysaccharides (LPSs) from Helicobacter pylori poses a challenge to establish accurate and strain-specific structure-function relationships in interactions with the host. Here, LPS structural domains from five clinical isolates were obtained and compared with the reference strain 26695.
12p viginny 30-12-2022 9 2 Download
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Human immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and communication could thus potentially alter host protection. Here, we explore this hypothesis by applying single-cell RNA-sequencing to examine viral responses among the dendritic cells (DCs) of three elite controllers (ECs) of HIV-1 infection.
21p vialfrednobel 29-01-2022 10 0 Download
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Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.
3p vialfrednobel 29-01-2022 13 0 Download
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Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable niche and survive inside of host macrophages. Macrophages can control or eliminate the infection, if acquire appropriate functional phenotypes.
16p vigiselle2711 30-08-2021 5 1 Download
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Fish gut microbial assemblages play a crucial role in the growth rate, metabolism, and immunity of the host. We hypothesized that the gut microbiota of rainbow trout was correlated with breeding program based genetic selection for muscle yield.
10p vijeeni2711 30-06-2021 13 1 Download
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Host immune function can contribute to numerous ecological/evolutionary processes. Ecoimmunological studies, however, typically use one/few phenotypic immune assays and thus do not consider the complexity of the immune system.
16p vilichoo2711 23-06-2021 10 1 Download
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Rodent malaria parasites are important models for studying host-malaria parasite interactions such as host immune response, mechanisms of parasite evasion of host killing, and vaccine development.
12p vilichoo2711 23-06-2021 7 1 Download
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Plant transcription factors (TFs) are key transcriptional regulators to manipulate the regulatory network of host immunity. However, the globally transcriptional reprogramming of plant TF families in response to pathogens, especially between the resistant and susceptible host plants, remains largely unknown.
14p vijichea2711 28-05-2021 12 1 Download
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Probiotics are a group of microorganisms that when administered in adequate amounts, confer a health benefit on the host. They build up health effects by number of ways viz. improving immune function, enhancing proper digestion, fighting against pathogens etc. Various species are proved to possess probiotic properties. Most important is that the selected probiotic strain must be able to survive in human gut, as the gut offers a difficult environment. In the present study, lactic acid bacteria was isolated from curd and its probiotic potentials were evaluated.
8p nguaconbaynhay6 23-06-2020 23 1 Download
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Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule.
12p viorochimaru2711 30-05-2020 8 0 Download
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Though the immunity to malaria has been associated with cellular immune responses, the exact function of the phenotypic cell population is still unclear. This study investigated the host immune responses elicited during the pre-erythrocytic stage, post-Plasmodium yoelii sporozoite infection in Swiss mice model. For this purpose, we analyzed the dynamics of different subsets of immune cells population and cytokine levels in the hepatic mononuclear and splenic cells population during pre-erythrocytic liver-stage infection.
13p partimesinhvien 08-05-2020 8 1 Download
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Salmonella typhi is the Gram negative bacteria that have the ability to infect humans via transferring an effector protein into host cells through type III secretion system. This effector protein starts interfering various host mechanisms which helps in bacterial survival. Antibiotics activate the immune system against infection but sometimes bacteria develop resistance by modulating its mechanism. The present study was carried out to explore an uncharacterized gene which may be involved in infection enhancement.
6p kethamoi4 16-04-2020 10 1 Download
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Plants are exposed to various types of pathogens and pests throughout their life including viruses, bacteria, fungi, oomycetes, nematodes and insects. Plants have evolved for different strategies to combat pathogen entry and disease development. Pathogenic microorganisms have their own strategies to overcome plant defense responses. Pathogens secrete ‘effector’ molecules which manipulate host cell structure and function to facilitate successful infection and also trigger defense responses in host cells. New emerging concept of ‘effector’ has been put forth in this review.
6p quenchua4 06-04-2020 12 1 Download
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The gut micro flora plays vital role in health status of the host. Human physiology and nutrition are greatly affected by the majority of microbes living in the gut. The most dominant phyla, making up to 90 percent of the total microbial population in humans are Bacteroidetes and Firmicutes followed by Actinobacteria Proteobacteria, Tenericutes, and Verrucomicrobia.
14p cothumenhmong3 22-02-2020 43 1 Download